CRCGN014_HEPG2_24H:G05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methoxychlor 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

143 genes differentially expressed following the CRCGN014_HEPG2_24H:G05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.02765
MVP major vault protein 4.73692
PRR15L proline rich 15-like 4.59336
CNPY3 canopy FGF signaling regulator 3 4.02556
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.59757
INPP1 inositol polyphosphate-1-phosphatase 3.54373
TRIB3 tribbles pseudokinase 3 3.48062
NOSIP nitric oxide synthase interacting protein 3.44663
PPARG peroxisome proliferator-activated receptor gamma 3.44369
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.39977
SQSTM1 sequestosome 1 3.38616
ATP11B ATPase, class VI, type 11B 3.38358
VAT1 vesicle amine transport 1 3.31842
SNAP25 synaptosomal-associated protein, 25kDa 3.30057
CIAO3 cytosolic iron-sulfur assembly component 3 3.21068
MYLK myosin light chain kinase 3.16295
CTSL cathepsin L 3.09874
NPDC1 neural proliferation, differentiation and control, 1 3.09762
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 3.08579
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.96571
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.94693
HOXA10 homeobox A10 2.87287
TRIB1 tribbles pseudokinase 1 2.79657
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.70096
RPP38 ribonuclease P/MRP 38kDa subunit 2.64893
DDIT4 DNA-damage-inducible transcript 4 2.64576
EGR1 early growth response 1 2.61072
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.59631
SLC35F2 solute carrier family 35, member F2 2.58743
E2F2 E2F transcription factor 2 2.58582
KDM5A lysine (K)-specific demethylase 5A 2.57916
AARS1 alanyl-tRNA synthetase 1 2.53004
MBNL2 muscleblind-like splicing regulator 2 2.52616
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.46888
DIPK1A divergent protein kinase domain 1A 2.46372
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.45441
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.43028
RAB21 RAB21, member RAS oncogene family 2.39583
RAP1GAP RAP1 GTPase activating protein 2.31554
TBP TATA box binding protein 2.28977
CARMIL1 capping protein regulator and myosin 1 linker 1 2.28586
YJU2B YJU2 splicing factor homolog B 2.28147
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.24394
CAMTA2 calmodulin binding transcription activator 2 2.23638
PYCR1 pyrroline-5-carboxylate reductase 1 2.2177
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.14724
GSTZ1 glutathione S-transferase zeta 1 2.13328
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.13053
IGF2R insulin-like growth factor 2 receptor 2.12772
MTX1 metaxin 1 2.10056
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.10045
H2AC6 H2A clustered histone 6 2.10007
KIFBP kinesin family binding protein 2.09147
GLRX glutaredoxin (thioltransferase) 2.07976
ZZZ3 zinc finger, ZZ-type containing 3 2.06216
TERF2IP telomeric repeat binding factor 2, interacting protein 2.04705
DDRGK1 DDRGK domain containing 1 2.03872
KAT2A K(lysine) acetyltransferase 2A 2.02223
PYGB phosphorylase, glycogen; brain 2.01855
AMPD2 adenosine monophosphate deaminase 2 2.01646
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.00452
ICAM1 intercellular adhesion molecule 1 2.00064

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -7.37191
RFC2 replication factor C (activator 1) 2, 40kDa -5.87734
MELK maternal embryonic leucine zipper kinase -5.74822
CDC20 cell division cycle 20 -5.49925
PSRC1 proline/serine-rich coiled-coil 1 -5.32381
ZMIZ1 zinc finger, MIZ-type containing 1 -5.25705
UBE2C ubiquitin-conjugating enzyme E2C -5.21834
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.14369
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.05246
CDK1 cyclin-dependent kinase 1 -4.88182
PLK1 polo-like kinase 1 -4.58649
ZNF586 zinc finger protein 586 -4.48576
TOP2A topoisomerase (DNA) II alpha 170kDa -4.44988
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.44231
CCNA2 cyclin A2 -4.40323
ZDHHC6 zinc finger, DHHC-type containing 6 -4.00248
BIRC5 baculoviral IAP repeat containing 5 -3.9588
TUBB6 tubulin, beta 6 class V -3.95277
TCTN1 tectonic family member 1 -3.86375
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.8047
AURKB aurora kinase B -3.78918
HAT1 histone acetyltransferase 1 -3.65453
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.46858
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.33722
CDC25B cell division cycle 25B -3.18794
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.17906
LDHD lactate dehydrogenase D -3.15249
LBR lamin B receptor -3.06365
CDCA8 cell division cycle associated 8 -3.04166
KIF11 kinesin family member 11 -3.03183
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.01742
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.90817
ICAM3 intercellular adhesion molecule 3 -2.89659
KDM3A lysine (K)-specific demethylase 3A -2.87608
NCAPD2 non-SMC condensin I complex, subunit D2 -2.85183
KIF4A kinesin family member 4A -2.70092
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.67436
SPDL1 spindle apparatus coiled-coil protein 1 -2.65443
CHEK1 checkpoint kinase 1 -2.64549
HADH hydroxyacyl-CoA dehydrogenase -2.6389
ISOC1 isochorismatase domain containing 1 -2.63483
FOXM1 forkhead box M1 -2.62367
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.48234
UBE2S ubiquitin-conjugating enzyme E2S -2.45523
CCNF cyclin F -2.39444
MKI67 marker of proliferation Ki-67 -2.36485
HMGB2 high mobility group box 2 -2.35647
CDCA3 cell division cycle associated 3 -2.33845
MCM10 minichromosome maintenance complex component 10 -2.33621
H2AX H2A.X variant histone -2.32603
GTF2A2 general transcription factor IIA, 2, 12kDa -2.32527
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.32447
ZNF274 zinc finger protein 274 -2.32254
TRIP13 thyroid hormone receptor interactor 13 -2.29632
CDC25A cell division cycle 25A -2.29353
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.28753
ASF1B anti-silencing function 1B histone chaperone -2.27924
NUP85 nucleoporin 85kDa -2.25151
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.2455
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.21786
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.20226
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.16482
NVL nuclear VCP-like -2.14577
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.12363
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.09293
PGRMC1 progesterone receptor membrane component 1 -2.09291
INSIG1 insulin induced gene 1 -2.07675
UGDH UDP-glucose 6-dehydrogenase -2.07644
HJURP Holliday junction recognition protein -2.06736
EXOSC9 exosome component 9 -2.06151
CDK2 cyclin-dependent kinase 2 -2.05804
CENPA centromere protein A -2.05207
TLR4 toll-like receptor 4 -2.04997
CKAP2 cytoskeleton associated protein 2 -2.0493
DHFR dihydrofolate reductase -2.0469
EXO1 exonuclease 1 -2.04337
HMGN2 high mobility group nucleosomal binding domain 2 -2.02271
EGF epidermal growth factor -2.01287
KIFC1 kinesin family member C1 -2.0104
CENPI centromere protein I -2.00956
CENPE centromere protein E, 312kDa -2.00303