CRCGN014_HEPG2_24H:G09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN014_HEPG2_24H:G09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.54536
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.89247
LCN2 lipocalin 2 3.36351
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.216
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.1674
JADE2 jade family PHD finger 2 3.05076
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.77878
MYLK myosin light chain kinase 2.76548
CHN1 chimerin 1 2.70869
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.60548
UBQLN2 ubiquilin 2 2.57115
NOTCH1 notch 1 2.45505
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.41824
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.32428
HLA-DRA major histocompatibility complex, class II, DR alpha 2.18698
PRKCH protein kinase C, eta 2.1648
DYNLT3 dynein, light chain, Tctex-type 3 2.05324

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -4.2407
THAP11 THAP domain containing 11 -3.41772
TUBB6 tubulin, beta 6 class V -3.29357
CDC20 cell division cycle 20 -3.28638
NT5DC2 5'-nucleotidase domain containing 2 -2.78339
TM9SF3 transmembrane 9 superfamily member 3 -2.73977
CCNB2 cyclin B2 -2.73845
PCNA proliferating cell nuclear antigen -2.48688
RBM15B RNA binding motif protein 15B -2.33793
PCCB propionyl CoA carboxylase, beta polypeptide -2.29933
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.10967
OXA1L oxidase (cytochrome c) assembly 1-like -2.1095
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.03228