CRCGN014_HEPG2_24H:G13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description c.i. acid orange 10 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN014_HEPG2_24H:G13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 6.31134
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.2614
EVL Enah/Vasp-like 4.21265
SATB1 SATB homeobox 1 4.06041
MAMLD1 mastermind-like domain containing 1 3.9671
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.76666
LCN2 lipocalin 2 3.47438
SNAP25 synaptosomal-associated protein, 25kDa 3.36789
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.35465
UBQLN2 ubiquilin 2 3.3491
PPARG peroxisome proliferator-activated receptor gamma 3.26519
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.88366
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.72065
PEX11A peroxisomal biogenesis factor 11 alpha 2.66473
RXYLT1 ribitol xylosyltransferase 1 2.5463
TIAM1 T-cell lymphoma invasion and metastasis 1 2.40145
PMM2 phosphomannomutase 2 2.30279
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.26777
CHN1 chimerin 1 2.26024
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.23636
PRKCH protein kinase C, eta 2.19961
LPAR2 lysophosphatidic acid receptor 2 2.09534
UBE2A ubiquitin-conjugating enzyme E2A 2.09113
GADD45A growth arrest and DNA-damage-inducible, alpha 2.04995
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.00898

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -7.37849
LDHD lactate dehydrogenase D -6.37366
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.49848
ADI1 acireductone dioxygenase 1 -5.23996
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -4.03836
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.83233
OXA1L oxidase (cytochrome c) assembly 1-like -3.75157
LAP3 leucine aminopeptidase 3 -3.66315
TRIB3 tribbles pseudokinase 3 -3.3653
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.11245
TLR4 toll-like receptor 4 -3.08104
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.8048
FGFR4 fibroblast growth factor receptor 4 -2.64491
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.56395
ZMIZ1 zinc finger, MIZ-type containing 1 -2.36087
SNX11 sorting nexin 11 -2.25322
SCCPDH saccharopine dehydrogenase (putative) -2.23057
ZFHX4 zinc finger homeobox 4 -2.20565
NGRN neugrin, neurite outgrowth associated -2.09966
RGS2 regulator of G-protein signaling 2 -2.06827