CRCGN014_HEPG2_24H:G15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2's,6r,7r,z)-7-hydroxy-3',6,7,14-tetramethyl-2,9-dioxa-14-azaspiro[bicyclo[9.5.1]heptadec[11]ene-4,2'-oxirane]-3,8,17-trione 19.93 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN014_HEPG2_24H:G15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.66975
TIAM1 T-cell lymphoma invasion and metastasis 1 4.14679
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.61994
SFTPB surfactant protein B 2.66612
MAP7 microtubule-associated protein 7 2.6604
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.56725
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.52888
CDPF1 cysteine-rich, DPF motif domain containing 1 2.52627
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.39945
TBC1D31 TBC1 domain family, member 31 2.36881
PRR15L proline rich 15-like 2.36378
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.32252
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.2643
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.22263
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.21228
DIPK1A divergent protein kinase domain 1A 2.15955
LPAR2 lysophosphatidic acid receptor 2 2.13543
ZIC1 Zic family member 1 2.08141
PPARG peroxisome proliferator-activated receptor gamma 2.07075
CXCL2 chemokine (C-X-C motif) ligand 2 2.06335

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.24818
LDHD lactate dehydrogenase D -6.47932
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.97024
THAP11 THAP domain containing 11 -3.4517
DSG2 desmoglein 2 -3.35223
KDM3A lysine (K)-specific demethylase 3A -3.20249
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.18559
MTA1 metastasis associated 1 -3.16787
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.14296
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.12392
LAP3 leucine aminopeptidase 3 -2.93747
NGRN neugrin, neurite outgrowth associated -2.921
MAPK13 mitogen-activated protein kinase 13 -2.78212
TRIB3 tribbles pseudokinase 3 -2.67411
VDAC1 voltage-dependent anion channel 1 -2.61052
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.4866
CAB39 calcium binding protein 39 -2.4847
EGF epidermal growth factor -2.26548
FGFR4 fibroblast growth factor receptor 4 -2.24433
FBXL12 F-box and leucine-rich repeat protein 12 -2.10384