CRCGN014_HEPG2_24H:G20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfuric acid compound with 2-methyl-1,4-benzenediamine (1:1) 20.89 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

238 genes differentially expressed following the CRCGN014_HEPG2_24H:G20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 6.44856
PPARG peroxisome proliferator-activated receptor gamma 6.41995
SQOR sulfide quinone oxidoreductase 6.26469
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.69359
KIFBP kinesin family binding protein 5.10714
INPP1 inositol polyphosphate-1-phosphatase 4.78698
FOSL1 FOS-like antigen 1 4.68025
VAT1 vesicle amine transport 1 4.49119
ZFP36 ZFP36 ring finger protein 4.43484
TRIB3 tribbles pseudokinase 3 4.2936
ABHD4 abhydrolase domain containing 4 4.26053
SRC SRC proto-oncogene, non-receptor tyrosine kinase 4.18875
ATP11B ATPase, class VI, type 11B 4.1283
CCL2 chemokine (C-C motif) ligand 2 4.06303
MVP major vault protein 4.04935
CNPY3 canopy FGF signaling regulator 3 4.03144
STK10 serine/threonine kinase 10 3.96643
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.90672
RAP1GAP RAP1 GTPase activating protein 3.82377
ALAS1 5'-aminolevulinate synthase 1 3.74474
MOK MOK protein kinase 3.70551
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.64518
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.52871
SOCS2 suppressor of cytokine signaling 2 3.52767
TIMP2 TIMP metallopeptidase inhibitor 2 3.43754
SHB Src homology 2 domain containing adaptor protein B 3.36899
BZW2 basic leucine zipper and W2 domains 2 3.32194
DDIT4 DNA-damage-inducible transcript 4 3.24232
SQSTM1 sequestosome 1 3.20025
CXCR4 chemokine (C-X-C motif) receptor 4 3.18155
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.14828
NANOS3 nanos homolog 3 (Drosophila) 3.04453
NMU neuromedin U 2.971
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.88476
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.84468
YARS1 tyrosyl-tRNA synthetase 1 2.83066
GSTZ1 glutathione S-transferase zeta 1 2.81261
ZNF638 zinc finger protein 638 2.80068
CIAO3 cytosolic iron-sulfur assembly component 3 2.78489
TESK1 testis-specific kinase 1 2.74714
LDLRAP1 low density lipoprotein receptor adaptor protein 1 2.72643
PRKCD protein kinase C, delta 2.69799
MAP7 microtubule-associated protein 7 2.69083
KLHL21 kelch-like family member 21 2.66638
GCC2 GRIP and coiled-coil domain containing 2 2.65383
GPC1 glypican 1 2.65011
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.64262
STX1A syntaxin 1A (brain) 2.61238
TRIM8 tripartite motif containing 8 2.60973
SLC25A46 solute carrier family 25, member 46 2.59405
IL4R interleukin 4 receptor 2.56661
RALB v-ral simian leukemia viral oncogene homolog B 2.55561
HLA-DMB major histocompatibility complex, class II, DM beta 2.5445
MAST2 microtubule associated serine/threonine kinase 2 2.50707
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.47986
ACOT9 acyl-CoA thioesterase 9 2.47008
NOSIP nitric oxide synthase interacting protein 2.43056
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.41504
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.39254
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.38666
CDPF1 cysteine-rich, DPF motif domain containing 1 2.38052
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.37842
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.3759
HOXA10 homeobox A10 2.36889
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.36526
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.36022
FXYD5 FXYD domain containing ion transport regulator 5 2.34282
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.34271
CYCS cytochrome c, somatic 2.3425
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.34239
CAB39 calcium binding protein 39 2.3262
GTPBP2 GTP binding protein 2 2.32455
FAIM Fas apoptotic inhibitory molecule 2.32135
IER3 immediate early response 3 2.31146
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.2906
HLA-DRA major histocompatibility complex, class II, DR alpha 2.2898
SARS1 seryl-tRNA synthetase 1 2.27146
MBNL1 muscleblind-like splicing regulator 1 2.26609
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.24696
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.24486
CCP110 centriolar coiled coil protein 110kDa 2.24474
GRB10 growth factor receptor-bound protein 10 2.24265
SHTN1 shootin 1 2.22867
PLS1 plastin 1 2.19611
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.1796
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.15887
MSN moesin 2.15715
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.15609
CHMP6 charged multivesicular body protein 6 2.15275
MAP1S microtubule-associated protein 1S 2.14245
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.14218
MACF1 microtubule-actin crosslinking factor 1 2.13997
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 2.137
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.1274
PLK3 polo-like kinase 3 2.12168
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.12084
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.11961
LPAR2 lysophosphatidic acid receptor 2 2.11193
GSTO1 glutathione S-transferase omega 1 2.11077
TRIM13 tripartite motif containing 13 2.10972
GIPC1 GIPC PDZ domain containing family, member 1 2.09933
WDR13 WD repeat domain 13 2.09592
SFXN3 sideroflexin 3 2.08244
TRAPPC14 trafficking protein particle complex subunit 14 2.06086
RBM15B RNA binding motif protein 15B 2.04949
EVL Enah/Vasp-like 2.04897
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 2.03494
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 2.02822
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 2.02349
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.00384
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.00367
STAP2 signal transducing adaptor family member 2 2.00186

decreased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 -6.78849
PCNA proliferating cell nuclear antigen -6.70551
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.68639
B4GAT1 beta-1,4-glucuronyltransferase 1 -6.50474
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.4823
LDHD lactate dehydrogenase D -6.45312
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.35406
ZNF586 zinc finger protein 586 -6.03544
ISOC1 isochorismatase domain containing 1 -5.51706
CDC20 cell division cycle 20 -5.21551
PSRC1 proline/serine-rich coiled-coil 1 -5.10059
CD320 CD320 molecule -4.74579
PECR peroxisomal trans-2-enoyl-CoA reductase -4.60564
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.58816
TCTN1 tectonic family member 1 -4.56773
ALDOC aldolase C, fructose-bisphosphate -4.35321
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.13275
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.10181
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.09959
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.06233
FBXL12 F-box and leucine-rich repeat protein 12 -3.90472
CDK1 cyclin-dependent kinase 1 -3.82125
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.65129
SPAG4 sperm associated antigen 4 -3.62817
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.60348
MRPS2 mitochondrial ribosomal protein S2 -3.57934
NUP85 nucleoporin 85kDa -3.49529
SOAT2 sterol O-acyltransferase 2 -3.43533
AURKB aurora kinase B -3.42625
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.42596
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.29404
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.29026
CCNB2 cyclin B2 -3.28881
FGFR4 fibroblast growth factor receptor 4 -3.23653
UBE2C ubiquitin-conjugating enzyme E2C -3.18669
TLR4 toll-like receptor 4 -3.15341
PGAM4 phosphoglycerate mutase family member 4 -3.14316
RPS5 ribosomal protein S5 -3.12419
CCNA2 cyclin A2 -3.0784
PLK1 polo-like kinase 1 -3.06934
BIRC5 baculoviral IAP repeat containing 5 -3.06056
TUBB6 tubulin, beta 6 class V -3.05287
HMGA2 high mobility group AT-hook 2 -3.02156
TMEM109 transmembrane protein 109 -3.01045
AMDHD2 amidohydrolase domain containing 2 -3.00667
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.98289
ADI1 acireductone dioxygenase 1 -2.92937
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.92582
INSIG1 insulin induced gene 1 -2.8931
HADH hydroxyacyl-CoA dehydrogenase -2.86704
USP6NL USP6 N-terminal like -2.85484
SCAND1 SCAN domain containing 1 -2.82928
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.78584
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.75031
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.69888
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.63807
ECH1 enoyl CoA hydratase 1, peroxisomal -2.60311
CHEK2 checkpoint kinase 2 -2.60236
CCDC86 coiled-coil domain containing 86 -2.58161
TOP2A topoisomerase (DNA) II alpha 170kDa -2.56787
EED embryonic ectoderm development -2.56124
NCAPD2 non-SMC condensin I complex, subunit D2 -2.54909
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.54815
TMEM97 transmembrane protein 97 -2.5472
STMN1 stathmin 1 -2.54693
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.53925
PGM1 phosphoglucomutase 1 -2.53034
MIS18A MIS18 kinetochore protein A -2.51787
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.49531
ASF1B anti-silencing function 1B histone chaperone -2.48888
SLC35F2 solute carrier family 35, member F2 -2.48859
COL3A1 collagen, type III, alpha 1 -2.48369
NT5DC2 5'-nucleotidase domain containing 2 -2.48232
PXMP2 peroxisomal membrane protein 2, 22kDa -2.4753
TCERG1 transcription elongation regulator 1 -2.47155
ICAM3 intercellular adhesion molecule 3 -2.4598
ACAA1 acetyl-CoA acyltransferase 1 -2.43955
CKS1B CDC28 protein kinase regulatory subunit 1B -2.4239
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.40768
HAT1 histone acetyltransferase 1 -2.4033
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.39868
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.36748
VDAC1 voltage-dependent anion channel 1 -2.36211
FEN1 flap structure-specific endonuclease 1 -2.35294
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.34354
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.32774
ENOPH1 enolase-phosphatase 1 -2.30952
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.29289
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.28957
TK1 thymidine kinase 1, soluble -2.27319
PDIA5 protein disulfide isomerase family A, member 5 -2.23561
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.23553
DHCR7 7-dehydrocholesterol reductase -2.23432
INCENP inner centromere protein antigens 135/155kDa -2.2259
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.20627
PRPF4 pre-mRNA processing factor 4 -2.20169
CHL1 cell adhesion molecule L1-like -2.18974
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.18379
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.1754
ELAVL1 ELAV like RNA binding protein 1 -2.1719
UBE3C ubiquitin protein ligase E3C -2.13352
GAMT guanidinoacetate N-methyltransferase -2.12844
SLBP stem-loop binding protein -2.125
LAGE3 L antigen family, member 3 -2.12098
MLEC malectin -2.11951
C5 complement component 5 -2.0964
LBR lamin B receptor -2.09358
MED22 mediator complex subunit 22 -2.08935
ERLIN2 ER lipid raft associated 2 -2.08561
MSMO1 methylsterol monooxygenase 1 -2.08254
DSCC1 DNA replication and sister chromatid cohesion 1 -2.07853
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.07622
COL6A3 collagen, type VI, alpha 3 -2.0752
KIFC1 kinesin family member C1 -2.07153
TEDC2 tubulin epsilon and delta complex 2 -2.07116
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -2.07085
CALM3 calmodulin 3 (phosphorylase kinase, delta) -2.06934
ZNF134 zinc finger protein 134 -2.06861
CDK4 cyclin-dependent kinase 4 -2.04729
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.04708
KIF15 kinesin family member 15 -2.04583
RGN regucalcin -2.03448
BLM Bloom syndrome, RecQ helicase-like -2.01646
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.00727
DPH2 DPH2 homolog (S. cerevisiae) -2.00151
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.00089