CRCGN014_HEPG2_24H:G21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dioxane 40.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN014_HEPG2_24H:G21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.68965
CCL2 chemokine (C-C motif) ligand 2 5.21856
LCN2 lipocalin 2 4.88851
BZW2 basic leucine zipper and W2 domains 2 4.87919
RPP38 ribonuclease P/MRP 38kDa subunit 4.8369
E2F2 E2F transcription factor 2 4.79153
CBR3 carbonyl reductase 3 4.74626
ADRB2 adrenoceptor beta 2, surface 4.67753
CHMP6 charged multivesicular body protein 6 4.39213
VAV3 vav 3 guanine nucleotide exchange factor 4.30415
JADE2 jade family PHD finger 2 4.10752
KDM5A lysine (K)-specific demethylase 5A 3.93453
TIAM1 T-cell lymphoma invasion and metastasis 1 3.8538
EPHB2 EPH receptor B2 3.78144
CCNF cyclin F 3.3808
EPN2 epsin 2 3.30136
NMU neuromedin U 3.21813
ABHD6 abhydrolase domain containing 6 3.14626
CARMIL1 capping protein regulator and myosin 1 linker 1 2.962
DHDDS dehydrodolichyl diphosphate synthase 2.91596
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.88247
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.87442
UBQLN2 ubiquilin 2 2.77844
AMDHD2 amidohydrolase domain containing 2 2.64023
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.60311
CGRRF1 cell growth regulator with ring finger domain 1 2.59835
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.56971
IFI44L interferon-induced protein 44-like 2.47858
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.38398
FCHO1 FCH domain only 1 2.37707
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.37294
CHN1 chimerin 1 2.37287
FOXJ2 forkhead box J2 2.35948
FZD7 frizzled class receptor 7 2.33614
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 2.32376
ZBP1 Z-DNA binding protein 1 2.30905
TMEM208 transmembrane protein 208 2.27831
KCNIP2 Kv channel interacting protein 2 2.27755
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 2.20394
KRT76 keratin 76, type II 2.17608
RSAD2 radical S-adenosyl methionine domain containing 2 2.15018
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.15008
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.14077
TRIM21 tripartite motif containing 21 2.13171
GPR39 G protein-coupled receptor 39 2.12655
GPATCH8 G patch domain containing 8 2.12123
HOXC8 homeobox C8 2.11169
OSGEP O-sialoglycoprotein endopeptidase 2.10032
WNT6 wingless-type MMTV integration site family, member 6 2.09034
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.06842
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.06214
LHX1 LIM homeobox 1 2.06101
ATP5MC3 ATP synthase membrane subunit c locus 3 2.05965
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.05912
GJD2 gap junction protein, delta 2, 36kDa 2.03857
BET1L Bet1 golgi vesicular membrane trafficking protein-like 2.0273
ATL2 atlastin GTPase 2 2.01505
RIGI RNA sensor RIG-I 2.01132

decreased expression

Symbol Name Standardized Value
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -6.64169
PCNA proliferating cell nuclear antigen -5.91637
CCDC86 coiled-coil domain containing 86 -4.8934
PCCB propionyl CoA carboxylase, beta polypeptide -4.8669
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.82611
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.72623
KDM3A lysine (K)-specific demethylase 3A -4.658
TM9SF3 transmembrane 9 superfamily member 3 -4.31341
CCNB1 cyclin B1 -4.03904
MAPK13 mitogen-activated protein kinase 13 -3.77368
ADI1 acireductone dioxygenase 1 -3.4977
NGRN neugrin, neurite outgrowth associated -3.18138
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.17821
FBXL12 F-box and leucine-rich repeat protein 12 -3.04907
CCNB2 cyclin B2 -2.99823
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.98328
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.97451
TRAPPC3 trafficking protein particle complex 3 -2.89404
YME1L1 YME1-like 1 ATPase -2.85754
HMG20B high mobility group 20B -2.82715
TOMM70 translocase of outer mitochondrial membrane 70 -2.80801
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.67446
DERA deoxyribose-phosphate aldolase (putative) -2.61595
CHIC2 cysteine-rich hydrophobic domain 2 -2.53772
TXNRD1 thioredoxin reductase 1 -2.37378
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.31282
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.24831
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -2.23037
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 -2.07495
EPCAM epithelial cell adhesion molecule -2.04283
VDAC1 voltage-dependent anion channel 1 -2.00323