CRCGN014_HEPG2_24H:G24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrobenzene 41.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

203 genes differentially expressed following the CRCGN014_HEPG2_24H:G24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 7.02605
PPARG peroxisome proliferator-activated receptor gamma 6.06122
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.71088
GSTZ1 glutathione S-transferase zeta 1 4.52964
MAP7 microtubule-associated protein 7 3.94082
PEX11A peroxisomal biogenesis factor 11 alpha 3.77532
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.72791
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.68762
C2CD2 C2 calcium-dependent domain containing 2 3.61646
CCDC92 coiled-coil domain containing 92 3.53542
NOTCH1 notch 1 3.41449
EVL Enah/Vasp-like 3.34772
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.31275
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.24267
STAP2 signal transducing adaptor family member 2 3.16821
TATDN2 TatD DNase domain containing 2 3.14758
MSRA methionine sulfoxide reductase A 3.1294
INTS3 integrator complex subunit 3 3.12571
CCL2 chemokine (C-C motif) ligand 2 3.01488
ATP11B ATPase, class VI, type 11B 2.99214
MAMLD1 mastermind-like domain containing 1 2.98184
BACE2 beta-site APP-cleaving enzyme 2 2.97936
RPP38 ribonuclease P/MRP 38kDa subunit 2.93055
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.92314
KAT6A K(lysine) acetyltransferase 6A 2.92255
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.89246
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.87444
ADGRE5 adhesion G protein-coupled receptor E5 2.85966
MCOLN1 mucolipin 1 2.8409
UBQLN2 ubiquilin 2 2.83187
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.82065
E2F2 E2F transcription factor 2 2.80427
SYNE2 spectrin repeat containing, nuclear envelope 2 2.7937
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.78741
VAV3 vav 3 guanine nucleotide exchange factor 2.73462
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.72402
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.69769
KLHL21 kelch-like family member 21 2.68451
PNKP polynucleotide kinase 3'-phosphatase 2.57522
SMIM40 small integral membrane protein 40 2.56071
ANO3 anoctamin 3 2.54485
CARMIL1 capping protein regulator and myosin 1 linker 1 2.53629
AXIN1 axin 1 2.5097
ADRB2 adrenoceptor beta 2, surface 2.48572
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.48021
ADGRG1 adhesion G protein-coupled receptor G1 2.44428
MMP2 matrix metallopeptidase 2 2.41557
BZW2 basic leucine zipper and W2 domains 2 2.40764
CLDN14 claudin 14 2.38934
POU3F3 POU class 3 homeobox 3 2.37463
ACVR2B activin A receptor, type IIB 2.37236
ADGRB1 adhesion G protein-coupled receptor B1 2.36519
CRIPTO3 cripto, EGF-CFC family member 3 2.34476
CRYBA4 crystallin, beta A4 2.3445
MTNR1A melatonin receptor 1A 2.34315
PLS1 plastin 1 2.32759
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.32628
FGF16 fibroblast growth factor 16 2.32618
ABHD6 abhydrolase domain containing 6 2.29928
ZBTB7C zinc finger and BTB domain containing 7C 2.27573
CCDC88C coiled-coil domain containing 88C 2.26561
EDDM3A epididymal protein 3A 2.25851
LPAR2 lysophosphatidic acid receptor 2 2.25675
MOK MOK protein kinase 2.25623
DHDDS dehydrodolichyl diphosphate synthase 2.25598
MYLK myosin light chain kinase 2.25006
AMDHD2 amidohydrolase domain containing 2 2.24645
DOT1L DOT1-like histone H3K79 methyltransferase 2.24049
ENOX2 ecto-NOX disulfide-thiol exchanger 2 2.23726
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 2.23723
KLF15 Kruppel-like factor 15 2.2284
RAB40C RAB40C, member RAS oncogene family 2.22794
MYRIP myosin VIIA and Rab interacting protein 2.21955
GPR6 G protein-coupled receptor 6 2.21687
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.21108
AKAP5 A kinase (PRKA) anchor protein 5 2.21048
ZNF180 zinc finger protein 180 2.20917
IL9 interleukin 9 2.20372
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.20318
ONECUT1 one cut homeobox 1 2.20283
PCDHB13 protocadherin beta 13 2.1951
CNTFR ciliary neurotrophic factor receptor 2.19333
NTN1 netrin 1 2.1835
WDR4 WD repeat domain 4 2.1829
JPH3 junctophilin 3 2.17676
ANGPT4 angiopoietin 4 2.17389
FSCN2 fascin actin-bundling protein 2, retinal 2.16787
TIAM1 T-cell lymphoma invasion and metastasis 1 2.16408
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.15716
GADD45G growth arrest and DNA-damage-inducible, gamma 2.15612
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.15549
CAMKV CaM kinase-like vesicle-associated 2.14596
SSTR1 somatostatin receptor 1 2.14556
LMO7 LIM domain 7 2.14419
MCMBP minichromosome maintenance complex binding protein 2.14347
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.14083
MRLN myoregulin 2.14073
CLIC2 chloride intracellular channel 2 2.12866
TREH trehalase (brush-border membrane glycoprotein) 2.12764
TLX1 T-cell leukemia homeobox 1 2.12486
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 2.12146
TOGARAM1 TOG array regulator of axonemal microtubules 1 2.12059
ST7L suppression of tumorigenicity 7 like 2.11999
KLHL36 kelch-like family member 36 2.11966
KRT36 keratin 36, type I 2.11725
CNTLN centlein, centrosomal protein 2.11067
FSHR follicle stimulating hormone receptor 2.10954
TAS2R3 taste receptor, type 2, member 3 2.10921
HOXC5 homeobox C5 2.10629
INSL6 insulin-like 6 2.10597
ZNF215 zinc finger protein 215 2.10555
GPX5 glutathione peroxidase 5 2.10201
TLR6 toll-like receptor 6 2.10181
S100A5 S100 calcium binding protein A5 2.09945
GATA3 GATA binding protein 3 2.09748
CCDC177 coiled-coil domain containing 177 2.09241
SLC30A3 solute carrier family 30 (zinc transporter), member 3 2.08545
KLF8 Kruppel-like factor 8 2.08511
TTPA tocopherol (alpha) transfer protein 2.08109
POU6F2 POU class 6 homeobox 2 2.07054
ZIM2 zinc finger, imprinted 2 2.0701
CTIF CBP80/20-dependent translation initiation factor 2.06921
BDNF brain-derived neurotrophic factor 2.06869
PFKL phosphofructokinase, liver 2.06786
EVC Ellis van Creveld protein 2.06496
BRS3 bombesin-like receptor 3 2.06269
ABHD8 abhydrolase domain containing 8 2.06238
EDDM3B epididymal protein 3B 2.05685
AMHR2 anti-Mullerian hormone receptor, type II 2.05581
LOC124906741 sperm-associated antigen 11B-like 2.05434
SH2D3C SH2 domain containing 3C 2.0528
GPALPP1 GPALPP motifs containing 1 2.04906
ADAM7 ADAM metallopeptidase domain 7 2.04831
FGF6 fibroblast growth factor 6 2.04758
OVOL3 ovo-like zinc finger 3 2.04571
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.04169
S1PR2 sphingosine-1-phosphate receptor 2 2.03998
APOL5 apolipoprotein L, 5 2.03644
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.03231
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.03164
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) 2.02733
PHEX phosphate regulating endopeptidase homolog, X-linked 2.02576
NPBWR2 neuropeptides B/W receptor 2 2.02396
FRMD1 FERM domain containing 1 2.02231
BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.02012
H3-4 H3.4 histone, cluster member 2.01462
KDM5A lysine (K)-specific demethylase 5A 2.00713
MYBPC3 myosin binding protein C, cardiac 2.00503
MYO19 myosin XIX 2.00175
CFAP46 cilia and flagella associated protein 46 2.00105
HES2 hes family bHLH transcription factor 2 2.00061
COL19A1 collagen, type XIX, alpha 1 2.00043

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.85023
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.62432
CCDC86 coiled-coil domain containing 86 -6.57333
TRIB3 tribbles pseudokinase 3 -5.90392
PCNA proliferating cell nuclear antigen -4.73984
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.06817
NT5DC2 5'-nucleotidase domain containing 2 -3.76008
GDF15 growth differentiation factor 15 -3.62541
HAT1 histone acetyltransferase 1 -3.43403
DUSP6 dual specificity phosphatase 6 -3.13511
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.10033
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.99669
CDC20 cell division cycle 20 -2.9797
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.96041
RPIA ribose 5-phosphate isomerase A -2.95812
PCCB propionyl CoA carboxylase, beta polypeptide -2.9124
TLCD3A TLC domain containing 3A -2.90232
CCNB1 cyclin B1 -2.78434
DNM1L dynamin 1-like -2.74383
KDM3A lysine (K)-specific demethylase 3A -2.71474
NCK1 NCK adaptor protein 1 -2.67496
COG7 component of oligomeric golgi complex 7 -2.64257
TSPAN4 tetraspanin 4 -2.62763
ACAA1 acetyl-CoA acyltransferase 1 -2.61647
THAP11 THAP domain containing 11 -2.60497
CCNB2 cyclin B2 -2.59426
MRPS2 mitochondrial ribosomal protein S2 -2.55665
PRCP prolylcarboxypeptidase (angiotensinase C) -2.55491
UGDH UDP-glucose 6-dehydrogenase -2.53885
DSG2 desmoglein 2 -2.53586
HEATR1 HEAT repeat containing 1 -2.52209
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.50603
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.50234
FAIM Fas apoptotic inhibitory molecule -2.49674
LAP3 leucine aminopeptidase 3 -2.40883
FASTKD5 FAST kinase domains 5 -2.39249
GNAS GNAS complex locus -2.3537
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -2.32632
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -2.31857
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.28853
CHKA choline kinase alpha -2.24637
TM9SF3 transmembrane 9 superfamily member 3 -2.20063
CHMP4B charged multivesicular body protein 4B -2.17776
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.17691
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.144
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.12942
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.09988
OXA1L oxidase (cytochrome c) assembly 1-like -2.04707
FHL2 four and a half LIM domains 2 -2.04276
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.03711
YME1L1 YME1-like 1 ATPase -2.00397