CRCGN014_HEPG2_24H:H03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-amino-2-methylanthraquinone 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

101 genes differentially expressed following the CRCGN014_HEPG2_24H:H03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 6.74657
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 6.43057
ADRB2 adrenoceptor beta 2, surface 6.28445
CXCL2 chemokine (C-X-C motif) ligand 2 4.9335
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.39635
LCN2 lipocalin 2 4.29945
ADGRE5 adhesion G protein-coupled receptor E5 3.96033
GPER1 G protein-coupled estrogen receptor 1 3.90941
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.61906
SFTPB surfactant protein B 3.61749
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.54739
PPARG peroxisome proliferator-activated receptor gamma 3.40368
TXNRD1 thioredoxin reductase 1 3.3633
CEP57 centrosomal protein 57kDa 3.35004
UBQLN2 ubiquilin 2 3.34475
EGF epidermal growth factor 3.27018
VAT1 vesicle amine transport 1 3.23743
RAP1GAP RAP1 GTPase activating protein 3.22316
CSK c-src tyrosine kinase 3.08273
TATDN2 TatD DNase domain containing 2 2.9888
PRKCH protein kinase C, eta 2.9434
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.90189
MINDY1 MINDY lysine 48 deubiquitinase 1 2.8755
HMOX1 heme oxygenase 1 2.83158
CYCS cytochrome c, somatic 2.81219
ABHD4 abhydrolase domain containing 4 2.71829
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.68831
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.62783
UGDH UDP-glucose 6-dehydrogenase 2.62751
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.57736
NOSIP nitric oxide synthase interacting protein 2.54276
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.52127
GSTZ1 glutathione S-transferase zeta 1 2.48528
GATA3 GATA binding protein 3 2.47477
SORBS3 sorbin and SH3 domain containing 3 2.42182
CTSL cathepsin L 2.39273
ERBB3 erb-b2 receptor tyrosine kinase 3 2.32852
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 2.29595
BMP4 bone morphogenetic protein 4 2.27448
CDC25B cell division cycle 25B 2.2502
MVP major vault protein 2.24499
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.21754
TP53 tumor protein p53 2.18134
CHMP6 charged multivesicular body protein 6 2.18057
FOXI1 forkhead box I1 2.17726
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.17591
VAV3 vav 3 guanine nucleotide exchange factor 2.16104
CASQ2 calsequestrin 2 (cardiac muscle) 2.10873
PLS1 plastin 1 2.10204
BPHL biphenyl hydrolase-like (serine hydrolase) 2.09274
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.08533
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 2.08238
PIEZO1 piezo-type mechanosensitive ion channel component 1 2.07297
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.05991
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.03988
HDGFL3 HDGF like 3 2.02942

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -6.43123
PCNA proliferating cell nuclear antigen -4.53825
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.04409
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.70839
ZNF586 zinc finger protein 586 -3.64957
ALDOC aldolase C, fructose-bisphosphate -3.62739
OXA1L oxidase (cytochrome c) assembly 1-like -3.56708
TLCD3A TLC domain containing 3A -3.48831
NRIP1 nuclear receptor interacting protein 1 -3.48748
MRPS2 mitochondrial ribosomal protein S2 -3.11001
DNM1L dynamin 1-like -3.08071
TLR4 toll-like receptor 4 -3.06094
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.98376
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.9385
KDM3A lysine (K)-specific demethylase 3A -2.91623
SOAT2 sterol O-acyltransferase 2 -2.91592
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.88531
SMNDC1 survival motor neuron domain containing 1 -2.87329
FAIM Fas apoptotic inhibitory molecule -2.81408
S100A4 S100 calcium binding protein A4 -2.81122
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.80691
LDHD lactate dehydrogenase D -2.75373
SNX11 sorting nexin 11 -2.51301
TXLNG taxilin gamma -2.40068
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.38625
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.38262
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.35634
TM9SF3 transmembrane 9 superfamily member 3 -2.33267
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.33121
BHLHE40 basic helix-loop-helix family, member e40 -2.28162
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.2671
ZMIZ1 zinc finger, MIZ-type containing 1 -2.24494
ADNP activity-dependent neuroprotector homeobox -2.23629
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.23145
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.22047
EZR ezrin -2.18238
TCTN1 tectonic family member 1 -2.16979
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.16672
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.11365
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.11112
ANKRD40 ankyrin repeat domain 40 -2.08916
TMEM97 transmembrane protein 97 -2.03836
LGMN legumain -2.02441
NUCB2 nucleobindin 2 -2.02115
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.00243