| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 40.6 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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80 genes differentially expressed following the CRCGN014_HEPG2_24H:H08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 6.60781 |
| MYLK | myosin light chain kinase | 6.58284 |
| CNPY3 | canopy FGF signaling regulator 3 | 6.37808 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 5.81358 |
| SQOR | sulfide quinone oxidoreductase | 5.19981 |
| UBQLN2 | ubiquilin 2 | 3.92661 |
| ZFP36 | ZFP36 ring finger protein | 3.5977 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.41835 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.36639 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.35299 |
| INPP1 | inositol polyphosphate-1-phosphatase | 3.34717 |
| EAPP | E2F-associated phosphoprotein | 3.33785 |
| CTSL | cathepsin L | 3.10723 |
| KIFBP | kinesin family binding protein | 3.1041 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 3.00279 |
| TRIB3 | tribbles pseudokinase 3 | 2.85293 |
| VAT1 | vesicle amine transport 1 | 2.83023 |
| NOSIP | nitric oxide synthase interacting protein | 2.81495 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.79868 |
| EPHA3 | EPH receptor A3 | 2.70592 |
| GLRX | glutaredoxin (thioltransferase) | 2.55068 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 2.5126 |
| MVP | major vault protein | 2.5117 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.47342 |
| SLC35F2 | solute carrier family 35, member F2 | 2.4121 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2.34896 |
| PRR15L | proline rich 15-like | 2.34499 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.28766 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.22127 |
| IGF2R | insulin-like growth factor 2 receptor | 2.21738 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 2.20696 |
| SQSTM1 | sequestosome 1 | 2.17205 |
| TBP | TATA box binding protein | 2.1708 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.16947 |
| IL4R | interleukin 4 receptor | 2.11931 |
| GPATCH8 | G patch domain containing 8 | 2.10669 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.01164 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NT5DC2 | 5'-nucleotidase domain containing 2 | -6.74251 |
| PCNA | proliferating cell nuclear antigen | -5.28068 |
| CCNB1 | cyclin B1 | -4.73229 |
| TCTN1 | tectonic family member 1 | -4.21131 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.69456 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.37847 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -3.10492 |
| PLK1 | polo-like kinase 1 | -3.09141 |
| CDC25B | cell division cycle 25B | -2.98259 |
| LDHD | lactate dehydrogenase D | -2.96511 |
| UGDH | UDP-glucose 6-dehydrogenase | -2.94128 |
| CDC20 | cell division cycle 20 | -2.9181 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.84912 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.84693 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -2.84268 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.83815 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -2.81291 |
| CDK1 | cyclin-dependent kinase 1 | -2.75219 |
| CCNA2 | cyclin A2 | -2.66773 |
| AURKB | aurora kinase B | -2.55378 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.54832 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.54463 |
| ISOC1 | isochorismatase domain containing 1 | -2.5247 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.4841 |
| TK1 | thymidine kinase 1, soluble | -2.46902 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | -2.46355 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.43535 |
| GOLT1B | golgi transport 1B | -2.43473 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.41182 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.39384 |
| CHEK1 | checkpoint kinase 1 | -2.37918 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.358 |
| LBR | lamin B receptor | -2.35702 |
| ADI1 | acireductone dioxygenase 1 | -2.34802 |
| ICAM3 | intercellular adhesion molecule 3 | -2.32605 |
| MELK | maternal embryonic leucine zipper kinase | -2.25842 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.21339 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.18009 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -2.16005 |
| STMN1 | stathmin 1 | -2.10228 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -2.08822 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -2.07487 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -2.06103 |
