CRCGN014_HEPG2_24H:H10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN014_HEPG2_24H:H10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 8.17928
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.47126
C2CD2 C2 calcium-dependent domain containing 2 5.08805
E2F2 E2F transcription factor 2 4.67404
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.44879
FZD7 frizzled class receptor 7 4.24189
SMIM40 small integral membrane protein 40 3.80534
CDPF1 cysteine-rich, DPF motif domain containing 1 3.77298
CYCS cytochrome c, somatic 2.85503
JADE2 jade family PHD finger 2 2.60135
LPAR2 lysophosphatidic acid receptor 2 2.5865
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.55922
PRR15L proline rich 15-like 2.42106
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.3864
CNPY3 canopy FGF signaling regulator 3 2.30572
HAVCR1 hepatitis A virus cellular receptor 1 2.26876
PDZK1 PDZ domain containing 1 2.24364
CD40 CD40 molecule, TNF receptor superfamily member 5 2.24236
HRAS Harvey rat sarcoma viral oncogene homolog 2.11944
BPHL biphenyl hydrolase-like (serine hydrolase) 2.09623
ACY1 aminoacylase 1 2.09093
PHF10 PHD finger protein 10 2.08488
ENO3 enolase 3 (beta, muscle) 2.04059

decreased expression

Symbol Name Standardized Value
RFC2 replication factor C (activator 1) 2, 40kDa -5.30783
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.86048
PCNA proliferating cell nuclear antigen -4.78469
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.7542
OXA1L oxidase (cytochrome c) assembly 1-like -4.74013
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.66009
LDHD lactate dehydrogenase D -4.0197
RHEB Ras homolog enriched in brain -3.94035
MAPK13 mitogen-activated protein kinase 13 -3.34552
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.32459
EGF epidermal growth factor -2.69558
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.68154
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.4577
RGS2 regulator of G-protein signaling 2 -2.17005
HSPA8 heat shock 70kDa protein 8 -2.14922
TXNDC9 thioredoxin domain containing 9 -2.13683
MAGEA10 melanoma antigen family A10 -2.11937
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -2.07761
MACF1 microtubule-actin crosslinking factor 1 -2.05899
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.05826
SLFN12 schlafen family member 12 -2.05089
ANKH ANKH inorganic pyrophosphate transport regulator -2.04966
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -2.03943
NRIP1 nuclear receptor interacting protein 1 -2.02492
LNPEP leucyl/cystinyl aminopeptidase -2.02316
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -2.02092
HLA-DMA major histocompatibility complex, class II, DM alpha -2.01577
ADORA3 adenosine A3 receptor -2.0096