CRCGN014_HEPG2_24H:H11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description scopolamine hydrobromide tri-hydrate 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN014_HEPG2_24H:H11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.96311
CHN1 chimerin 1 3.94768
MOK MOK protein kinase 3.77587
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.53739
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.43813
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.31703
UBQLN2 ubiquilin 2 3.20194
MAMLD1 mastermind-like domain containing 1 3.05062
AMDHD2 amidohydrolase domain containing 2 3.02037
RPP38 ribonuclease P/MRP 38kDa subunit 2.99135
MEF2C myocyte enhancer factor 2C 2.95922
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.92339
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.67728
BAMBI BMP and activin membrane-bound inhibitor 2.67561
KIF20A kinesin family member 20A 2.43898
MAP7 microtubule-associated protein 7 2.43289
CCL2 chemokine (C-C motif) ligand 2 2.3807

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -6.48016
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.38166
VAT1 vesicle amine transport 1 -3.35305
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.18824
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.12533
GDF15 growth differentiation factor 15 -3.09908
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.06443
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.78155
PCNA proliferating cell nuclear antigen -2.69038
OXA1L oxidase (cytochrome c) assembly 1-like -2.62397
FGFR4 fibroblast growth factor receptor 4 -2.60773
SNX11 sorting nexin 11 -2.50824
DDIT4 DNA-damage-inducible transcript 4 -2.36328
ELOVL1 ELOVL fatty acid elongase 1 -2.24502