CRCGN014_HEPG2_24H:H16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrimethamine 40.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

165 genes differentially expressed following the CRCGN014_HEPG2_24H:H16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 6.40251
MAP7 microtubule-associated protein 7 5.11369
S100A4 S100 calcium binding protein A4 5.00072
CDC45 cell division cycle 45 4.80355
KIFBP kinesin family binding protein 4.62879
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.58195
IGFBP3 insulin-like growth factor binding protein 3 4.51435
LCN2 lipocalin 2 4.17017
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.97372
IER3 immediate early response 3 3.94711
CIAO3 cytosolic iron-sulfur assembly component 3 3.93696
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.92307
EDN1 endothelin 1 3.90452
LGALS8 lectin, galactoside-binding, soluble, 8 3.88531
ACOT9 acyl-CoA thioesterase 9 3.74514
E2F2 E2F transcription factor 2 3.5983
GLRX glutaredoxin (thioltransferase) 3.54215
CARMIL1 capping protein regulator and myosin 1 linker 1 3.43023
CYCS cytochrome c, somatic 3.41198
ADGRE5 adhesion G protein-coupled receptor E5 3.32181
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.12296
TIMP2 TIMP metallopeptidase inhibitor 2 3.11133
MSRA methionine sulfoxide reductase A 3.06155
ATP11B ATPase, class VI, type 11B 3.06025
NOTCH1 notch 1 2.93151
FAIM Fas apoptotic inhibitory molecule 2.92655
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.81178
MICALL1 MICAL-like 1 2.80041
CDPF1 cysteine-rich, DPF motif domain containing 1 2.72036
TUBB6 tubulin, beta 6 class V 2.71277
GATA3 GATA binding protein 3 2.68793
TESK1 testis-specific kinase 1 2.67091
CEMIP2 cell migration inducing hyaluronidase 2 2.63492
DUSP6 dual specificity phosphatase 6 2.6346
MAST2 microtubule associated serine/threonine kinase 2 2.60276
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.59017
INPP1 inositol polyphosphate-1-phosphatase 2.58526
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.5411
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.42834
PTK2 protein tyrosine kinase 2 2.42695
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.42654
TWSG1 twisted gastrulation BMP signaling modulator 1 2.41684
DDB2 damage-specific DNA binding protein 2, 48kDa 2.39178
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 2.38657
GOLT1B golgi transport 1B 2.37959
DIPK1A divergent protein kinase domain 1A 2.3452
MVP major vault protein 2.2996
LAP3 leucine aminopeptidase 3 2.29572
SOCS2 suppressor of cytokine signaling 2 2.29251
CDK7 cyclin-dependent kinase 7 2.2858
CHMP6 charged multivesicular body protein 6 2.26793
TWF2 twinfilin actin binding protein 2 2.23792
GSTZ1 glutathione S-transferase zeta 1 2.19533
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.18955
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.1676
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.16288
LPAR2 lysophosphatidic acid receptor 2 2.15061
DYNLT3 dynein, light chain, Tctex-type 3 2.13825
ITFG1 integrin alpha FG-GAP repeat containing 1 2.13065
SECTM1 secreted and transmembrane 1 2.12284
PRR15L proline rich 15-like 2.09838
CCP110 centriolar coiled coil protein 110kDa 2.09126
SLC75A1 solute carrier family 75 member 1 2.08361
SMIM40 small integral membrane protein 40 2.07411
STK38L serine/threonine kinase 38 like 2.05642
CUL4B cullin 4B 2.04904
MICU1 mitochondrial calcium uptake 1 2.04231
EVL Enah/Vasp-like 2.04156
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.00601
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 2.00418
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.0034

decreased expression

Symbol Name Standardized Value
ANKRD10 ankyrin repeat domain 10 -7.32892
ISOC1 isochorismatase domain containing 1 -5.70129
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.5833
PECR peroxisomal trans-2-enoyl-CoA reductase -5.51362
NT5DC2 5'-nucleotidase domain containing 2 -5.37756
RXYLT1 ribitol xylosyltransferase 1 -5.24373
CDC20 cell division cycle 20 -5.06416
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.57294
DERA deoxyribose-phosphate aldolase (putative) -4.56007
ETFB electron-transfer-flavoprotein, beta polypeptide -4.54429
TCTN1 tectonic family member 1 -4.47988
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.42027
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.36626
PSRC1 proline/serine-rich coiled-coil 1 -4.35066
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -4.21171
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.92515
PLK1 polo-like kinase 1 -3.74744
FGFR4 fibroblast growth factor receptor 4 -3.67649
CCNA2 cyclin A2 -3.58783
TRIB3 tribbles pseudokinase 3 -3.54684
RUVBL1 RuvB-like AAA ATPase 1 -3.53265
PYCR1 pyrroline-5-carboxylate reductase 1 -3.51775
MRPL12 mitochondrial ribosomal protein L12 -3.46738
SNX11 sorting nexin 11 -3.32106
INTS3 integrator complex subunit 3 -3.26828
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -3.18735
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.18703
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -3.16566
RPP38 ribonuclease P/MRP 38kDa subunit -3.16203
ZDHHC6 zinc finger, DHHC-type containing 6 -3.05926
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.04157
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.98817
NLRP2B NLR family pyrin domain containing 2B -2.97831
MRPS2 mitochondrial ribosomal protein S2 -2.96709
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.91585
GSTM2 glutathione S-transferase mu 2 (muscle) -2.9136
LAGE3 L antigen family, member 3 -2.87918
RHEB Ras homolog enriched in brain -2.80568
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.78264
NIT1 nitrilase 1 -2.76525
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.75074
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.74802
TLCD3A TLC domain containing 3A -2.73329
LBR lamin B receptor -2.71981
GALE UDP-galactose-4-epimerase -2.69532
MAPK13 mitogen-activated protein kinase 13 -2.66219
YME1L1 YME1-like 1 ATPase -2.5627
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.53291
LYRM1 LYR motif containing 1 -2.5246
TOP2A topoisomerase (DNA) II alpha 170kDa -2.48682
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.47806
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.46824
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.46741
TCERG1 transcription elongation regulator 1 -2.45471
BLMH bleomycin hydrolase -2.45142
DDIT4 DNA-damage-inducible transcript 4 -2.43926
COG4 component of oligomeric golgi complex 4 -2.42286
ELAVL1 ELAV like RNA binding protein 1 -2.40656
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.40378
HEATR1 HEAT repeat containing 1 -2.39979
MELK maternal embryonic leucine zipper kinase -2.38215
SNF8 SNF8, ESCRT-II complex subunit -2.38201
PEG10 paternally expressed 10 -2.38038
HADH hydroxyacyl-CoA dehydrogenase -2.37529
MTMR4 myotubularin related protein 4 -2.34527
KIF18B kinesin family member 18B -2.33838
CDK4 cyclin-dependent kinase 4 -2.32385
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.30105
HMG20B high mobility group 20B -2.29705
PKNOX2 PBX/knotted 1 homeobox 2 -2.27605
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.27263
EBNA1BP2 EBNA1 binding protein 2 -2.24703
MSMO1 methylsterol monooxygenase 1 -2.20978
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.20275
RGN regucalcin -2.18038
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.17217
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.15941
SMAD5 SMAD family member 5 -2.1213
ZNF586 zinc finger protein 586 -2.11445
NUP62 nucleoporin 62kDa -2.10646
STK16 serine/threonine kinase 16 -2.10559
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.10261
CCNB1 cyclin B1 -2.09879
BIRC5 baculoviral IAP repeat containing 5 -2.0905
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.0905
FASTKD5 FAST kinase domains 5 -2.09021
PGRMC1 progesterone receptor membrane component 1 -2.0797
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.04406
RPIA ribose 5-phosphate isomerase A -2.03769
BAX BCL2-associated X protein -2.01985
CCDC92 coiled-coil domain containing 92 -2.01985
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -2.01767
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.01202
TMEM14A transmembrane protein 14A -2.0008