| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 21.82 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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76 genes differentially expressed following the CRCGN014_HEPG2_24H:H20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 10.0 |
| MAP7 | microtubule-associated protein 7 | 7.25576 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 5.2936 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.76924 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 4.36593 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 4.29081 |
| EPN2 | epsin 2 | 4.28022 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 3.89355 |
| TESK1 | testis-specific kinase 1 | 3.23931 |
| BAD | BCL2-associated agonist of cell death | 3.22731 |
| JADE2 | jade family PHD finger 2 | 3.19133 |
| CEP57 | centrosomal protein 57kDa | 3.1657 |
| SFTPB | surfactant protein B | 3.0731 |
| FZD7 | frizzled class receptor 7 | 2.88983 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.71613 |
| TBXA2R | thromboxane A2 receptor | 2.67751 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.57901 |
| HMOX1 | heme oxygenase 1 | 2.54559 |
| GSTA1 | glutathione S-transferase alpha 1 | 2.47341 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.30705 |
| ZNF528 | zinc finger protein 528 | 2.2571 |
| GRAMD1C | GRAM domain containing 1C | 2.25343 |
| TBP | TATA box binding protein | 2.25191 |
| RXYLT1 | ribitol xylosyltransferase 1 | 2.2418 |
| RIMS1 | regulating synaptic membrane exocytosis 1 | 2.22423 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.21968 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 2.20224 |
| CLCN6 | chloride channel, voltage-sensitive 6 | 2.16122 |
| LSR | lipolysis stimulated lipoprotein receptor | 2.13879 |
| HAO2 | hydroxyacid oxidase 2 (long chain) | 2.13763 |
| NOSIP | nitric oxide synthase interacting protein | 2.12477 |
| TSPAN12 | tetraspanin 12 | 2.11472 |
| ZDHHC13 | zinc finger, DHHC-type containing 13 | 2.10102 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 2.0995 |
| ZNF180 | zinc finger protein 180 | 2.08852 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 2.08172 |
| CCNA1 | cyclin A1 | 2.0764 |
| KMT5A | lysine methyltransferase 5A | 2.06118 |
| VBP1 | von Hippel-Lindau binding protein 1 | 2.03675 |
| CYCS | cytochrome c, somatic | 2.03417 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.03083 |
| KCTD11 | potassium channel tetramerization domain containing 11 | 2.02069 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | -4.87686 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | -4.50758 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -4.46837 |
| TSPAN4 | tetraspanin 4 | -4.39252 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -4.34781 |
| CDC20 | cell division cycle 20 | -4.34054 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.32929 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -4.20418 |
| CCDC86 | coiled-coil domain containing 86 | -3.92684 |
| GDF15 | growth differentiation factor 15 | -3.81556 |
| COG7 | component of oligomeric golgi complex 7 | -3.71336 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -3.6089 |
| TLCD3A | TLC domain containing 3A | -3.56387 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.49239 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -3.31353 |
| CCNB1 | cyclin B1 | -3.05257 |
| RHEB | Ras homolog enriched in brain | -3.04937 |
| LYPLA1 | lysophospholipase I | -3.04386 |
| PAM16 | presequence translocase-associated motor 16 homolog (S. cerevisiae) | -2.71588 |
| MPHOSPH8 | M-phase phosphoprotein 8 | -2.30952 |
| PPOX | protoporphyrinogen oxidase | -2.28552 |
| HEATR1 | HEAT repeat containing 1 | -2.27196 |
| ELP3 | elongator acetyltransferase complex subunit 3 | -2.23547 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -2.22713 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | -2.21134 |
| POLR3E | polymerase (RNA) III (DNA directed) polypeptide E (80kD) | -2.15622 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -2.13628 |
| WNT2 | wingless-type MMTV integration site family member 2 | -2.13216 |
| TNIP1 | TNFAIP3 interacting protein 1 | -2.10364 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -2.07949 |
| HEXB | hexosaminidase B (beta polypeptide) | -2.06677 |
| HSPA8 | heat shock 70kDa protein 8 | -2.0652 |
| FSTL1 | follistatin-like 1 | -2.02953 |
| UCK2 | uridine-cytidine kinase 2 | -2.00288 |
