CRCGN014_HEPG2_24H:H23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 20.71 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN014_HEPG2_24H:H23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 3.85392
CCL2 chemokine (C-C motif) ligand 2 3.58798
BACE2 beta-site APP-cleaving enzyme 2 3.54867
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.20355
ATP11B ATPase, class VI, type 11B 2.80327
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.80245
MAP7 microtubule-associated protein 7 2.59772
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.44463
MAST2 microtubule associated serine/threonine kinase 2 2.19475
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.13825
NOSIP nitric oxide synthase interacting protein 2.01537
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.00976

decreased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 -6.63198
LDHD lactate dehydrogenase D -6.39647
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.26213
PCNA proliferating cell nuclear antigen -5.13491
ZNF586 zinc finger protein 586 -3.68837
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.6341
ZMIZ1 zinc finger, MIZ-type containing 1 -3.59746
VDAC1 voltage-dependent anion channel 1 -3.42115
TLR4 toll-like receptor 4 -3.30484
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.25992
CHMP4B charged multivesicular body protein 4B -3.24937
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.12214
TUBB6 tubulin, beta 6 class V -3.06846
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.99952
FGFR4 fibroblast growth factor receptor 4 -2.99392
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.75265
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.54478
CDC20 cell division cycle 20 -2.47338
GNAS GNAS complex locus -2.39411
MRPS2 mitochondrial ribosomal protein S2 -2.29762
TCTN1 tectonic family member 1 -2.01962