CRCGN014_HEPG2_24H:I01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetracycline 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

143 genes differentially expressed following the CRCGN014_HEPG2_24H:I01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.52011
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 5.70122
DDIT4 DNA-damage-inducible transcript 4 5.09852
CNPY3 canopy FGF signaling regulator 3 5.05997
TRIB3 tribbles pseudokinase 3 5.03757
JADE2 jade family PHD finger 2 4.18419
GRB10 growth factor receptor-bound protein 10 4.08053
INPP1 inositol polyphosphate-1-phosphatase 3.95977
RBM15B RNA binding motif protein 15B 3.90724
RPP38 ribonuclease P/MRP 38kDa subunit 3.61289
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.59742
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.4333
PPARG peroxisome proliferator-activated receptor gamma 3.43018
E2F2 E2F transcription factor 2 3.43007
CIAO3 cytosolic iron-sulfur assembly component 3 3.36558
MBTPS1 membrane-bound transcription factor peptidase, site 1 3.3617
ADRB2 adrenoceptor beta 2, surface 3.28986
LCN2 lipocalin 2 3.28854
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.26858
AARS1 alanyl-tRNA synthetase 1 3.23732
PDGFA platelet-derived growth factor alpha polypeptide 3.09724
NPDC1 neural proliferation, differentiation and control, 1 3.02291
GSTZ1 glutathione S-transferase zeta 1 3.01351
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.97944
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.86577
MAP7 microtubule-associated protein 7 2.85063
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.81148
PHGDH phosphoglycerate dehydrogenase 2.79709
EXOC5 exocyst complex component 5 2.79147
CCP110 centriolar coiled coil protein 110kDa 2.77269
DSG2 desmoglein 2 2.7685
PRKCQ protein kinase C, theta 2.67827
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.67464
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.63937
ABHD6 abhydrolase domain containing 6 2.62902
SLC75A1 solute carrier family 75 member 1 2.55912
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.55417
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.53269
YARS1 tyrosyl-tRNA synthetase 1 2.5044
CLIC4 chloride intracellular channel 4 2.50141
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.49209
BZW2 basic leucine zipper and W2 domains 2 2.48708
IPO8 importin 8 2.47444
TES testin LIM domain protein 2.47006
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.40569
CDC45 cell division cycle 45 2.40169
NMU neuromedin U 2.40146
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.3861
PROSER1 proline and serine rich 1 2.31163
DIPK1A divergent protein kinase domain 1A 2.24459
ATF4 activating transcription factor 4 2.23887
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.22877
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough 2.22858
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.2278
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.22565
THOC6 THO complex 6 2.20186
TXNRD1 thioredoxin reductase 1 2.19905
ZMIZ1 zinc finger, MIZ-type containing 1 2.19726
GARS1 glycyl-tRNA synthetase 1 2.18025
FKBP5 FK506 binding protein 5 2.17659
PSEN1 presenilin 1 2.17113
TRIB1 tribbles pseudokinase 1 2.16727
ABR active BCR-related 2.13623
HOOK1 hook microtubule-tethering protein 1 2.13181
EPHA3 EPH receptor A3 2.11915
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2.11839
ZFP69B ZFP69 zinc finger protein B 2.10701
CSNK1A1 casein kinase 1, alpha 1 2.0978
R3HCC1L R3H domain and coiled-coil containing 1-like 2.09121
TARS1 threonyl-tRNA synthetase 1 2.07043
SFTPB surfactant protein B 2.07017
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.06565
ZNF589 zinc finger protein 589 2.03851
NUP133 nucleoporin 133kDa 2.03627
CAB39L calcium binding protein 39-like 2.01479
POGK pogo transposable element with KRAB domain 2.00759
PYCR1 pyrroline-5-carboxylate reductase 1 2.00697

decreased expression

Symbol Name Standardized Value
TCTN1 tectonic family member 1 -6.73003
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.48827
ALDOC aldolase C, fructose-bisphosphate -4.87862
CDC20 cell division cycle 20 -4.78608
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.547
NUP85 nucleoporin 85kDa -4.47891
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.41787
ACAA1 acetyl-CoA acyltransferase 1 -4.38593
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.12674
LOC124907782 dual specificity protein phosphatase 22 -3.95764
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.9161
ZDHHC6 zinc finger, DHHC-type containing 6 -3.86107
CD320 CD320 molecule -3.81681
SOAT2 sterol O-acyltransferase 2 -3.81469
CTSL cathepsin L -3.60633
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.55671
ICAM3 intercellular adhesion molecule 3 -3.51377
RFC2 replication factor C (activator 1) 2, 40kDa -3.47528
MELK maternal embryonic leucine zipper kinase -3.45288
UBE2C ubiquitin-conjugating enzyme E2C -3.44266
S100A4 S100 calcium binding protein A4 -3.42229
DCK deoxycytidine kinase -3.35513
TMEM97 transmembrane protein 97 -3.32477
PSRC1 proline/serine-rich coiled-coil 1 -3.32063
PGM1 phosphoglucomutase 1 -3.28166
CDK1 cyclin-dependent kinase 1 -3.27856
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.2155
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.03414
CCNA2 cyclin A2 -2.99911
ZNF274 zinc finger protein 274 -2.93803
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.90469
LDHD lactate dehydrogenase D -2.8549
HAT1 histone acetyltransferase 1 -2.85344
OXA1L oxidase (cytochrome c) assembly 1-like -2.77413
EGF epidermal growth factor -2.68094
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.49881
TOP2A topoisomerase (DNA) II alpha 170kDa -2.48685
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.45906
GJA1 gap junction protein, alpha 1, 43kDa -2.43616
PCNA proliferating cell nuclear antigen -2.40339
PGAM4 phosphoglycerate mutase family member 4 -2.39917
STMN1 stathmin 1 -2.39038
CRELD2 cysteine-rich with EGF-like domains 2 -2.38723
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.37965
CDC25B cell division cycle 25B -2.36698
NLRP2B NLR family pyrin domain containing 2B -2.31761
PLK1 polo-like kinase 1 -2.2558
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.22063
SELENOW selenoprotein W -2.21832
CCNB2 cyclin B2 -2.19892
NUCB2 nucleobindin 2 -2.16972
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.16488
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.15769
CCNB1 cyclin B1 -2.15489
KCTD2 potassium channel tetramerization domain containing 2 -2.14212
FHL2 four and a half LIM domains 2 -2.08814
HELLS helicase, lymphoid-specific -2.08689
MCM5 minichromosome maintenance complex component 5 -2.08367
BLMH bleomycin hydrolase -2.07131
CHEK2 checkpoint kinase 2 -2.06401
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.0603
COL6A3 collagen, type VI, alpha 3 -2.03998
CDC6 cell division cycle 6 -2.03834
UNC119 unc-119 homolog (C. elegans) -2.02511
AURKB aurora kinase B -2.01154
TK1 thymidine kinase 1, soluble -2.00515