CRCGN014_HEPG2_24H:I05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dibutyl-2-oxohydrazine 21.49 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN014_HEPG2_24H:I05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 4.89575
EVL Enah/Vasp-like 3.86703
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.73554
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.5053
PLSCR1 phospholipid scramblase 1 3.27141
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.20677
VGLL4 vestigial-like family member 4 3.18484
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.7859
CXCL2 chemokine (C-X-C motif) ligand 2 2.74845
COPS7A COP9 signalosome subunit 7A 2.68045
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.55803
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.48912
TSPAN6 tetraspanin 6 2.25867
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.09133
TCTA T-cell leukemia translocation altered 2.02377
PRR15L proline rich 15-like 2.00381

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -5.77892
TP53BP2 tumor protein p53 binding protein 2 -5.64044
VAT1 vesicle amine transport 1 -5.2984
UGDH UDP-glucose 6-dehydrogenase -4.28657
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.04751
ISOC1 isochorismatase domain containing 1 -3.8668
GNAS GNAS complex locus -3.57149
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.38693
LDHD lactate dehydrogenase D -3.33303
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.24614
PLK1 polo-like kinase 1 -3.23633
MAPK13 mitogen-activated protein kinase 13 -3.20943
NGRN neugrin, neurite outgrowth associated -3.01899
PRPF4 pre-mRNA processing factor 4 -2.84738
RFC2 replication factor C (activator 1) 2, 40kDa -2.71736
SLC35F2 solute carrier family 35, member F2 -2.5674
CHIC2 cysteine-rich hydrophobic domain 2 -2.5518
OXA1L oxidase (cytochrome c) assembly 1-like -2.22151
CD58 CD58 molecule -2.19741
HSPA8 heat shock 70kDa protein 8 -2.16125
RGS2 regulator of G-protein signaling 2 -2.09788
EGF epidermal growth factor -2.07449
NVL nuclear VCP-like -2.07112
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.01784
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.01157