CRCGN014_HEPG2_24H:I06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ITE 20.96 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN014_HEPG2_24H:I06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EGF epidermal growth factor 5.12877
CNPY3 canopy FGF signaling regulator 3 4.29378
KLHL21 kelch-like family member 21 3.71711
VAT1 vesicle amine transport 1 3.70832
CIAO3 cytosolic iron-sulfur assembly component 3 3.45691
GPER1 G protein-coupled estrogen receptor 1 3.28196
MVP major vault protein 3.15628
STAP2 signal transducing adaptor family member 2 3.04059
CRYZ crystallin, zeta (quinone reductase) 2.76697
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.68969
SQOR sulfide quinone oxidoreductase 2.66256
PLSCR1 phospholipid scramblase 1 2.56821
PLS1 plastin 1 2.55654
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.47639
MAMLD1 mastermind-like domain containing 1 2.32293
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.24184
KLHL9 kelch-like family member 9 2.11538
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 2.10112
FOS FBJ murine osteosarcoma viral oncogene homolog 2.10098
CDPF1 cysteine-rich, DPF motif domain containing 1 2.04757

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -7.4873
MAPK13 mitogen-activated protein kinase 13 -6.45976
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.4251
LDHD lactate dehydrogenase D -6.28799
DNM1L dynamin 1-like -3.90988
MRPS2 mitochondrial ribosomal protein S2 -3.6828
KDM3A lysine (K)-specific demethylase 3A -3.65095
C2CD5 C2 calcium-dependent domain containing 5 -3.5673
PSRC1 proline/serine-rich coiled-coil 1 -3.08161
SPAG4 sperm associated antigen 4 -3.07227
NCK1 NCK adaptor protein 1 -3.03874
HLA-DMA major histocompatibility complex, class II, DM alpha -3.02562
CCNB2 cyclin B2 -2.92377
FGFR4 fibroblast growth factor receptor 4 -2.92196
CLTB clathrin, light chain B -2.89839
ZNF586 zinc finger protein 586 -2.86793
UBE3C ubiquitin protein ligase E3C -2.70431
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.70399
ZMIZ1 zinc finger, MIZ-type containing 1 -2.5398
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.4584
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.4199
FHL2 four and a half LIM domains 2 -2.39937
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.21795
DDIT4 DNA-damage-inducible transcript 4 -2.15347
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.11282
DSG2 desmoglein 2 -2.02783
TLR4 toll-like receptor 4 -2.02044