CRCGN014_HEPG2_24H:I07 Gene Set
Dataset
Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category
transcriptomics
Type
small molecule perturbation
Description
disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)-5-hydroxybenzenesulfonate 20.28 um perturbation at 24 h in HEPG2 (Carcinogenome )
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Genes
37 genes differentially expressed following the CRCGN014_HEPG2_24H:I07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
increased expression
Symbol
Name
Standardized Value
P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
6.47713
MAP7
microtubule-associated protein 7
5.21377
GATA3
GATA binding protein 3
5.20196
CHMP6
charged multivesicular body protein 6
4.2627
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
3.75347
C2CD2
C2 calcium-dependent domain containing 2
3.54576
EGF
epidermal growth factor
3.44112
STK10
serine/threonine kinase 10
3.1696
GPER1
G protein-coupled estrogen receptor 1
3.05075
CEBPZ
CCAAT/enhancer binding protein (C/EBP), zeta
2.84027
CIAO3
cytosolic iron-sulfur assembly component 3
2.69144
KIF20A
kinesin family member 20A
2.59412
CEMIP2
cell migration inducing hyaluronidase 2
2.48067
LOC122526780
uncharacterized LOC122526780
2.47441
SNAP25
synaptosomal-associated protein, 25kDa
2.32115
KCNK1
potassium channel, two pore domain subfamily K, member 1
2.24175
DENND2D
DENN/MADD domain containing 2D
2.20884
RAB21
RAB21, member RAS oncogene family
2.01042
decreased expression
Symbol
Name
Standardized Value
LDHD
lactate dehydrogenase D
-6.3491
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
-6.14491
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
-4.68266
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
-4.37448
VAT1
vesicle amine transport 1
-3.66779
C2CD5
C2 calcium-dependent domain containing 5
-3.21809
ZNF586
zinc finger protein 586
-2.98508
TRIB3
tribbles pseudokinase 3
-2.86917
PLK1
polo-like kinase 1
-2.62423
FGFR4
fibroblast growth factor receptor 4
-2.42124
NRIP1
nuclear receptor interacting protein 1
-2.36296
FBXL12
F-box and leucine-rich repeat protein 12
-2.30192
GNAS
GNAS complex locus
-2.13384
MRPL15
mitochondrial ribosomal protein L15
-2.11079
WASHC4
WASH complex subunit 4
-2.11035
PIK3R2
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
-2.09695
ZFPM2
zinc finger protein, FOG family member 2
-2.08485
LOC102723713
TP53-target gene 3 protein
-2.07921
TTC1
tetratricopeptide repeat domain 1
-2.0001
