CRCGN014_HEPG2_24H:I09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-benzyl 2-butyl phthalate 21.13 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN014_HEPG2_24H:I09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 5.08741
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.07825
PNKP polynucleotide kinase 3'-phosphatase 4.84982
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.73835
ATP11B ATPase, class VI, type 11B 4.07549
MAP7 microtubule-associated protein 7 3.92941
HDGFL3 HDGF like 3 3.74752
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.68974
RRAGA Ras-related GTP binding A 3.54667
LYN LYN proto-oncogene, Src family tyrosine kinase 3.42949
NOSIP nitric oxide synthase interacting protein 3.33594
PLSCR3 phospholipid scramblase 3 3.11735
CDPF1 cysteine-rich, DPF motif domain containing 1 2.96213
BPHL biphenyl hydrolase-like (serine hydrolase) 2.84316
GATA2 GATA binding protein 2 2.74618
DIPK1A divergent protein kinase domain 1A 2.70151
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.623
LCN2 lipocalin 2 2.5557
GPER1 G protein-coupled estrogen receptor 1 2.41023
CXCL2 chemokine (C-X-C motif) ligand 2 2.40049
KDM5A lysine (K)-specific demethylase 5A 2.32329
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.29879
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2.18284
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.17623
NID2 nidogen 2 (osteonidogen) 2.1216
ELP5 elongator acetyltransferase complex subunit 5 2.05037
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.01492
NECAB3 N-terminal EF-hand calcium binding protein 3 2.00883

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.32933
FASTKD5 FAST kinase domains 5 -4.995
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.79251
DNM1L dynamin 1-like -4.48898
NT5DC2 5'-nucleotidase domain containing 2 -4.43297
TRIB3 tribbles pseudokinase 3 -4.34267
CDC20 cell division cycle 20 -4.30948
ARID5B AT rich interactive domain 5B (MRF1-like) -4.29082
GADD45A growth arrest and DNA-damage-inducible, alpha -3.84365
LDHD lactate dehydrogenase D -3.31882
CDC25B cell division cycle 25B -3.28545
CCNB2 cyclin B2 -2.93223
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.8947
EIF5 eukaryotic translation initiation factor 5 -2.82818
GGNBP2 gametogenetin binding protein 2 -2.80125
DERA deoxyribose-phosphate aldolase (putative) -2.75996
REEP5 receptor accessory protein 5 -2.45967
CTNNA2 catenin (cadherin-associated protein), alpha 2 -2.40635
FOS FBJ murine osteosarcoma viral oncogene homolog -2.38881
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.30317
RCOR3 REST corepressor 3 -2.28225
SLC6A16 solute carrier family 6, member 16 -2.2705
ZNF586 zinc finger protein 586 -2.16371
NDRG4 NDRG family member 4 -2.12956
TXNDC9 thioredoxin domain containing 9 -2.12791
EPB42 erythrocyte membrane protein band 4.2 -2.11459
DCK deoxycytidine kinase -2.02093