CRCGN014_HEPG2_24H:I14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulforaphane 19.97 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

231 genes differentially expressed following the CRCGN014_HEPG2_24H:I14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 9.27036
TXNRD1 thioredoxin reductase 1 6.81841
CBR1 carbonyl reductase 1 6.42512
CDPF1 cysteine-rich, DPF motif domain containing 1 6.19295
EGR1 early growth response 1 6.05195
SLC35F2 solute carrier family 35, member F2 5.77052
INPP1 inositol polyphosphate-1-phosphatase 5.33169
CIAO3 cytosolic iron-sulfur assembly component 3 5.27632
KEAP1 kelch-like ECH-associated protein 1 5.09317
FOSL1 FOS-like antigen 1 5.04161
ASCC3 activating signal cointegrator 1 complex subunit 3 4.41836
CNPY3 canopy FGF signaling regulator 3 4.38173
LSR lipolysis stimulated lipoprotein receptor 4.3734
H2BC12 H2B clustered histone 12 4.17089
TBPL1 TBP-like 1 4.16633
TRIB1 tribbles pseudokinase 1 3.93654
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.89729
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.84273
MAP7 microtubule-associated protein 7 3.79259
IER3 immediate early response 3 3.70593
MCOLN1 mucolipin 1 3.65896
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.613
ALAS1 5'-aminolevulinate synthase 1 3.60037
KLHL21 kelch-like family member 21 3.5539
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.53923
SQSTM1 sequestosome 1 3.49683
SMAD3 SMAD family member 3 3.42408
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.39161
TOMM34 translocase of outer mitochondrial membrane 34 3.34054
TIMP2 TIMP metallopeptidase inhibitor 2 3.26936
LRP10 low density lipoprotein receptor-related protein 10 3.22879
NLRP2B NLR family pyrin domain containing 2B 3.22415
DPH2 DPH2 homolog (S. cerevisiae) 3.21676
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 3.21288
CAB39 calcium binding protein 39 3.2059
TEX10 testis expressed 10 3.19143
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 3.14676
GNPDA1 glucosamine-6-phosphate deaminase 1 3.08867
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.08713
IL4R interleukin 4 receptor 3.04969
TERF2IP telomeric repeat binding factor 2, interacting protein 3.03227
PEX11A peroxisomal biogenesis factor 11 alpha 3.01071
RXYLT1 ribitol xylosyltransferase 1 2.96906
CCND3 cyclin D3 2.94324
CXCL2 chemokine (C-X-C motif) ligand 2 2.91136
FOS FBJ murine osteosarcoma viral oncogene homolog 2.85517
FBXL12 F-box and leucine-rich repeat protein 12 2.85396
DNM1L dynamin 1-like 2.84598
ADGRE5 adhesion G protein-coupled receptor E5 2.81158
IER2 immediate early response 2 2.7901
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.75835
KCTD5 potassium channel tetramerization domain containing 5 2.74867
BAD BCL2-associated agonist of cell death 2.71164
RPP38 ribonuclease P/MRP 38kDa subunit 2.7098
FPGS folylpolyglutamate synthase 2.69275
JADE2 jade family PHD finger 2 2.65372
RNASE7 ribonuclease, RNase A family, 7 2.56422
TUBB6 tubulin, beta 6 class V 2.51019
LSG1 large 60S subunit nuclear export GTPase 1 2.4657
RALB v-ral simian leukemia viral oncogene homolog B 2.42559
LRRC41 leucine rich repeat containing 41 2.39448
DUSP6 dual specificity phosphatase 6 2.3668
TICAM1 toll-like receptor adaptor molecule 1 2.3439
PPARG peroxisome proliferator-activated receptor gamma 2.3352
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.31728
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.29297
RAP1GAP RAP1 GTPase activating protein 2.28679
ICAM1 intercellular adhesion molecule 1 2.26977
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.26792
ECD ecdysoneless homolog (Drosophila) 2.26283
SCPEP1 serine carboxypeptidase 1 2.25808
PFDN1 prefoldin subunit 1 2.25248
ATG4A autophagy related 4A, cysteine peptidase 2.23884
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.21792
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.20918
PNKP polynucleotide kinase 3'-phosphatase 2.18759
GLRX glutaredoxin (thioltransferase) 2.16948
FDX1 ferredoxin 1 2.161
MRPS22 mitochondrial ribosomal protein S22 2.15038
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.1467
TP53BP2 tumor protein p53 binding protein 2 2.1324
DIPK1A divergent protein kinase domain 1A 2.11745
IGF2R insulin-like growth factor 2 receptor 2.1122
SP140 SP140 nuclear body protein 2.11062
CD2 CD2 molecule 2.0707
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.06915
ABHD2 abhydrolase domain containing 2 2.06587
RHOG ras homolog family member G 2.0647
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.0641
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.05512
MAP7D1 MAP7 domain containing 1 2.02984
CAVIN1 caveolae associated protein 1 2.02565
ATP11B ATPase, class VI, type 11B 2.02103
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.0153
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.00962

decreased expression

Symbol Name Standardized Value
FGFR4 fibroblast growth factor receptor 4 -7.77318
PCNA proliferating cell nuclear antigen -6.80349
PCCB propionyl CoA carboxylase, beta polypeptide -6.76411
RPS4Y1 ribosomal protein S4, Y-linked 1 -6.63721
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.43181
CDC20 cell division cycle 20 -5.42298
C2CD5 C2 calcium-dependent domain containing 5 -5.21916
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.20468
TCTN1 tectonic family member 1 -5.14474
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.72558
KLHDC2 kelch domain containing 2 -4.47156
MELK maternal embryonic leucine zipper kinase -4.46801
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.46796
CDK1 cyclin-dependent kinase 1 -4.4122
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.31203
USP6NL USP6 N-terminal like -4.29614
TLR4 toll-like receptor 4 -4.28373
PEG10 paternally expressed 10 -4.20105
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -4.17244
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.14806
NUP85 nucleoporin 85kDa -4.1349
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.11133
SOAT2 sterol O-acyltransferase 2 -4.10964
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -4.03978
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.03352
DCK deoxycytidine kinase -3.92957
PSRC1 proline/serine-rich coiled-coil 1 -3.92378
AURKB aurora kinase B -3.87387
TRIB3 tribbles pseudokinase 3 -3.79159
ACAA1 acetyl-CoA acyltransferase 1 -3.79135
PYCR1 pyrroline-5-carboxylate reductase 1 -3.73926
COG2 component of oligomeric golgi complex 2 -3.73566
CRELD2 cysteine-rich with EGF-like domains 2 -3.73339
CCNA2 cyclin A2 -3.67559
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.65294
TOP2A topoisomerase (DNA) II alpha 170kDa -3.64528
PGM1 phosphoglucomutase 1 -3.63144
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -3.61124
HMGA2 high mobility group AT-hook 2 -3.54311
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.36595
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.35522
HADH hydroxyacyl-CoA dehydrogenase -3.28372
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.27509
HAT1 histone acetyltransferase 1 -3.24138
STMN1 stathmin 1 -3.22771
AMDHD2 amidohydrolase domain containing 2 -3.16689
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.14006
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -3.12508
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.1061
ALDOC aldolase C, fructose-bisphosphate -3.08672
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.08003
ASF1B anti-silencing function 1B histone chaperone -3.06135
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.05033
RFC2 replication factor C (activator 1) 2, 40kDa -3.0264
DDIT4 DNA-damage-inducible transcript 4 -2.97866
LBR lamin B receptor -2.89264
KIF15 kinesin family member 15 -2.86677
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.85727
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.7848
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.78
PXMP2 peroxisomal membrane protein 2, 22kDa -2.76137
UBE2C ubiquitin-conjugating enzyme E2C -2.76028
LOC102724560 cystathionine beta-synthase -2.75471
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.75237
GMNN geminin, DNA replication inhibitor -2.73365
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.72395
KIFC1 kinesin family member C1 -2.69148
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.67736
TRAIP TRAF interacting protein -2.67653
CDC45 cell division cycle 45 -2.60058
KIF11 kinesin family member 11 -2.59795
S100A4 S100 calcium binding protein A4 -2.59518
RHOBTB1 Rho-related BTB domain containing 1 -2.5852
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -2.53438
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.48311
ENOPH1 enolase-phosphatase 1 -2.47511
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.46618
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.4469
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.4366
MIS18A MIS18 kinetochore protein A -2.42852
PLK1 polo-like kinase 1 -2.4158
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.39901
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -2.39654
VAV3 vav 3 guanine nucleotide exchange factor -2.36535
SQLE squalene epoxidase -2.36131
CLIC4 chloride intracellular channel 4 -2.35331
MTERF3 mitochondrial transcription termination factor 3 -2.32835
CDC25B cell division cycle 25B -2.32317
CDT1 chromatin licensing and DNA replication factor 1 -2.31835
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -2.31155
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.30957
ASGR1 asialoglycoprotein receptor 1 -2.30315
GNAS GNAS complex locus -2.30172
ADGRB2 adhesion G protein-coupled receptor B2 -2.29344
TCEA2 transcription elongation factor A (SII), 2 -2.29119
CHEK2 checkpoint kinase 2 -2.28086
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.27469
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.26564
NT5DC2 5'-nucleotidase domain containing 2 -2.26521
MYO10 myosin X -2.26484
TERT telomerase reverse transcriptase -2.24995
MSMO1 methylsterol monooxygenase 1 -2.2228
ZW10 zw10 kinetochore protein -2.19853
AMBP alpha-1-microglobulin/bikunin precursor -2.1898
GDF7 growth differentiation factor 7 -2.17645
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.15007
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.14748
LYZ lysozyme -2.14601
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.14315
NUCB2 nucleobindin 2 -2.14106
LMNB1 lamin B1 -2.12819
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.12658
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.12565
GFOD1 glucose-fructose oxidoreductase domain containing 1 -2.12465
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.11415
PYGL phosphorylase, glycogen, liver -2.1102
RAB15 RAB15, member RAS oncogene family -2.10268
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.09348
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.09332
PIMREG PICALM interacting mitotic regulator -2.09201
CX3CL1 chemokine (C-X3-C motif) ligand 1 -2.07731
MSH6 mutS homolog 6 -2.07475
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -2.05451
FBXO5 F-box protein 5 -2.05374
ACVR2B activin A receptor, type IIB -2.04673
ERBB3 erb-b2 receptor tyrosine kinase 3 -2.04428
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.0411
TRIP13 thyroid hormone receptor interactor 13 -2.0269
CSNK1E casein kinase 1, epsilon -2.02486
RAB4A RAB4A, member RAS oncogene family -2.0246
CETN2 centrin, EF-hand protein, 2 -2.02229
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.01878
COL1A2 collagen, type I, alpha 2 -2.01455
CBR4 carbonyl reductase 4 -2.01338
FHL2 four and a half LIM domains 2 -2.01294
RPS5 ribosomal protein S5 -2.00389