CRCGN014_HEPG2_24H:I15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description monoethylhexylphthalate 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN014_HEPG2_24H:I15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO1 anoctamin 1, calcium activated chloride channel 5.29001
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.9462
AMDHD2 amidohydrolase domain containing 2 4.8468
NOTCH1 notch 1 4.82162
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.57005
HEBP1 heme binding protein 1 4.42406
EPN2 epsin 2 4.31485
NPDC1 neural proliferation, differentiation and control, 1 3.48706
STIMATE STIM activating enhancer 3.33841
CXCL2 chemokine (C-X-C motif) ligand 2 3.29063
TXNL4B thioredoxin-like 4B 3.07732
CYCS cytochrome c, somatic 2.91383
PFKL phosphofructokinase, liver 2.87752
HLA-DRA major histocompatibility complex, class II, DR alpha 2.66492
ZNF589 zinc finger protein 589 2.59398
SFTPB surfactant protein B 2.51515
MPC2 mitochondrial pyruvate carrier 2 2.38672
PBLD phenazine biosynthesis-like protein domain containing 2.38627
CHN1 chimerin 1 2.36343
KAT6A K(lysine) acetyltransferase 6A 2.3322
MTX1 metaxin 1 2.27359
BPHL biphenyl hydrolase-like (serine hydrolase) 2.24257
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.20841
KIF20A kinesin family member 20A 2.12083
H1-10 H1.10 linker histone 2.07779
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.05349
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.03972
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 2.02661
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 2.00978

decreased expression

Symbol Name Standardized Value
FBXL12 F-box and leucine-rich repeat protein 12 -6.99993
CCNB2 cyclin B2 -6.37505
CDC20 cell division cycle 20 -5.44084
FASTKD5 FAST kinase domains 5 -5.41322
ZNF586 zinc finger protein 586 -5.32982
KDM3A lysine (K)-specific demethylase 3A -5.15994
PLK1 polo-like kinase 1 -5.03796
TRIB3 tribbles pseudokinase 3 -4.90341
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.51097
LDHD lactate dehydrogenase D -4.51002
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.4557
FGFR4 fibroblast growth factor receptor 4 -4.42139
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.16326
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.04217
VDAC1 voltage-dependent anion channel 1 -4.0359
TP53BP2 tumor protein p53 binding protein 2 -3.69762
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.44524
TLR4 toll-like receptor 4 -3.21759
CDC25B cell division cycle 25B -3.14792
ZMIZ1 zinc finger, MIZ-type containing 1 -2.92677
ICAM3 intercellular adhesion molecule 3 -2.76203
TXNDC9 thioredoxin domain containing 9 -2.68542
QPCTL glutaminyl-peptide cyclotransferase-like -2.26212
KRT38 keratin 38, type I -2.25481
GHSR growth hormone secretagogue receptor -2.23786
GPR52 G protein-coupled receptor 52 -2.22317
CAV3 caveolin 3 -2.21868
ZIM2 zinc finger, imprinted 2 -2.2183
RPS5 ribosomal protein S5 -2.19166
MYL4 myosin, light chain 4, alkali; atrial, embryonic -2.17305
KRT33B keratin 33B, type I -2.12238
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.11709
OR1E2 olfactory receptor, family 1, subfamily E, member 2 -2.0987
IL1A interleukin 1, alpha -2.08785
MAN1C1 mannosidase, alpha, class 1C, member 1 -2.08777
LIM2 lens intrinsic membrane protein 2, 19kDa -2.07905
UBASH3A ubiquitin associated and SH3 domain containing A -2.06682
NPY5R neuropeptide Y receptor Y5 -2.03943
OXA1L oxidase (cytochrome c) assembly 1-like -2.03085
RIOX1 ribosomal oxygenase 1 -2.02998
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.02965
SMAP1 small ArfGAP 1 -2.02512
OR1A1 olfactory receptor, family 1, subfamily A, member 1 -2.00659
CD1B CD1b molecule -2.00142