CRCGN014_HEPG2_24H:I17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-4-oxo-3-(2-propynyl)-2-cyclopenten-1-yl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate 21.18 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN014_HEPG2_24H:I17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.92203
CNPY3 canopy FGF signaling regulator 3 4.88001
LCN2 lipocalin 2 3.5427
CARMIL1 capping protein regulator and myosin 1 linker 1 3.36664
PPARG peroxisome proliferator-activated receptor gamma 2.71435
MAP7 microtubule-associated protein 7 2.63935
GLRX glutaredoxin (thioltransferase) 2.62632
NOSIP nitric oxide synthase interacting protein 2.51561
CCP110 centriolar coiled coil protein 110kDa 2.4908
INPP1 inositol polyphosphate-1-phosphatase 2.39713
GRB10 growth factor receptor-bound protein 10 2.28585
STK10 serine/threonine kinase 10 2.27009
CERK ceramide kinase 2.10073
TXNRD1 thioredoxin reductase 1 2.02001

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.08777
CDC25B cell division cycle 25B -4.92398
CCNB2 cyclin B2 -4.64044
ZNF586 zinc finger protein 586 -4.22012
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.50739
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.48603
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.36569
LDHD lactate dehydrogenase D -3.19881
FGFR4 fibroblast growth factor receptor 4 -3.00486
PCCB propionyl CoA carboxylase, beta polypeptide -2.98875
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.98629
PCNA proliferating cell nuclear antigen -2.78445
EIF5 eukaryotic translation initiation factor 5 -2.68523
PECR peroxisomal trans-2-enoyl-CoA reductase -2.51384
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.39287
DERA deoxyribose-phosphate aldolase (putative) -2.23947
PSRC1 proline/serine-rich coiled-coil 1 -2.23509
NRIP1 nuclear receptor interacting protein 1 -2.23283
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.06031
TOP2A topoisomerase (DNA) II alpha 170kDa -2.02977