CRCGN014_HEPG2_24H:I18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(1-methyl-2-oxohydrazino)-1-(3-pyridinyl)-1-butanone 20.11 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

278 genes differentially expressed following the CRCGN014_HEPG2_24H:I18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 10.0
PPARG peroxisome proliferator-activated receptor gamma 6.35613
RPP38 ribonuclease P/MRP 38kDa subunit 5.28085
CCDC92 coiled-coil domain containing 92 5.19616
KLHL21 kelch-like family member 21 5.00585
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.95355
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.95099
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.92579
RXYLT1 ribitol xylosyltransferase 1 4.91292
CBR3 carbonyl reductase 3 4.85084
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.8474
BACE2 beta-site APP-cleaving enzyme 2 4.78657
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.25955
FZD7 frizzled class receptor 7 4.23514
PFKL phosphofructokinase, liver 4.11447
JADE2 jade family PHD finger 2 4.00323
TIAM1 T-cell lymphoma invasion and metastasis 1 3.99864
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.81154
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.75713
NNT nicotinamide nucleotide transhydrogenase 3.72629
MAP7 microtubule-associated protein 7 3.60934
MICALL1 MICAL-like 1 3.55058
GATA3 GATA binding protein 3 3.41747
DIO3 deiodinase, iodothyronine, type III 3.34593
PLCD1 phospholipase C, delta 1 3.31231
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.25466
NOSIP nitric oxide synthase interacting protein 3.14059
BIRC2 baculoviral IAP repeat containing 2 3.07712
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.94744
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.90406
IRF1 interferon regulatory factor 1 2.89348
LOC122526780 uncharacterized LOC122526780 2.87701
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.86856
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 2.85435
PLEKHA6 pleckstrin homology domain containing, family A member 6 2.85391
APOL1 apolipoprotein L, 1 2.78865
PRRX2 paired related homeobox 2 2.76816
NXPH3 neurexophilin 3 2.754
CCDC85B coiled-coil domain containing 85B 2.7429
SMIM40 small integral membrane protein 40 2.73843
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.71159
ADM2 adrenomedullin 2 2.69901
GATD3 glutamine amidotransferase class 1 domain containing 3 2.68599
KIF5C kinesin family member 5C 2.66805
SH3BP1 SH3-domain binding protein 1 2.66631
CCIN calicin 2.65406
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.63932
SIRT3 sirtuin 3 2.63777
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.61297
CYB561 cytochrome b561 2.61288
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.61007
TTC26 tetratricopeptide repeat domain 26 2.59971
SNAP25 synaptosomal-associated protein, 25kDa 2.5915
CCDC9 coiled-coil domain containing 9 2.58975
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.57825
ADRB2 adrenoceptor beta 2, surface 2.57705
EVX1 even-skipped homeobox 1 2.56947
ZC4H2 zinc finger, C4H2 domain containing 2.56569
PKLR pyruvate kinase, liver and RBC 2.55739
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.54846
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.53588
RARG retinoic acid receptor, gamma 2.51327
GPER1 G protein-coupled estrogen receptor 1 2.50116
MAST2 microtubule associated serine/threonine kinase 2 2.49845
SPI1 Spi-1 proto-oncogene 2.49537
CRTAP cartilage associated protein 2.49274
CYBA cytochrome b-245, alpha polypeptide 2.47595
DCAF11 DDB1 and CUL4 associated factor 11 2.46169
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.44513
GUCA1B guanylate cyclase activator 1B (retina) 2.44215
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.42093
MACIR macrophage immunometabolism regulator 2.42078
CRYBG1 crystallin beta-gamma domain containing 1 2.41846
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.4091
BATF basic leucine zipper transcription factor, ATF-like 2.4011
HIC2 hypermethylated in cancer 2 2.39664
DIXDC1 DIX domain containing 1 2.39637
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.39563
LYRM1 LYR motif containing 1 2.38711
ACTC1 actin, alpha, cardiac muscle 1 2.37255
GSTA1 glutathione S-transferase alpha 1 2.36748
PRR5 proline rich 5 (renal) 2.34927
UPK1A uroplakin 1A 2.34442
OR3A3 olfactory receptor, family 3, subfamily A, member 3 2.32406
FLOT2 flotillin 2 2.32103
ACSM2A acyl-CoA synthetase medium-chain family member 2A 2.31105
FASLG Fas ligand (TNF superfamily, member 6) 2.3089
GRWD1 glutamate-rich WD repeat containing 1 2.30106
MLYCD malonyl-CoA decarboxylase 2.29442
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.2927
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.29251
HOXC5 homeobox C5 2.29167
STK32B serine/threonine kinase 32B 2.28767
RAB36 RAB36, member RAS oncogene family 2.26869
PLSCR1 phospholipid scramblase 1 2.25424
ZNF428 zinc finger protein 428 2.25292
RIPOR1 RHO family interacting cell polarization regulator 1 2.25258
GCAT glycine C-acetyltransferase 2.25174
IRF5 interferon regulatory factor 5 2.24539
MINDY1 MINDY lysine 48 deubiquitinase 1 2.23725
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.23343
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2.23086
CA9 carbonic anhydrase IX 2.22376
CER1 cerberus 1, DAN family BMP antagonist 2.22326
FER fer (fps/fes related) tyrosine kinase 2.22011
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.21924
MAN2A1 mannosidase, alpha, class 2A, member 1 2.21763
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 2.21523
DCAF15 DDB1 and CUL4 associated factor 15 2.21311
ATF7IP2 activating transcription factor 7 interacting protein 2 2.20553
BTN3A1 butyrophilin, subfamily 3, member A1 2.1998
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 2.19568
CAVIN3 caveolae associated protein 3 2.19375
ZBED5 zinc finger, BED-type containing 5 2.19317
NPFFR1 neuropeptide FF receptor 1 2.19094
OSBP2 oxysterol binding protein 2 2.18158
SLC7A4 solute carrier family 7, member 4 2.18033
EPHB6 EPH receptor B6 2.17043
VENTX VENT homeobox 2.16531
ADAM30 ADAM metallopeptidase domain 30 2.16201
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.15541
MIA melanoma inhibitory activity 2.15523
PGPEP1 pyroglutamyl-peptidase I 2.15219
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 2.14225
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.13187
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.13137
RNASE12 ribonuclease, RNase A family, 12 (non-active) 2.13116
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.12836
TDP1 tyrosyl-DNA phosphodiesterase 1 2.12703
ZNF180 zinc finger protein 180 2.12646
DKKL1 dickkopf-like 1 2.12626
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.12618
HBQ1 hemoglobin, theta 1 2.12585
ZNF197 zinc finger protein 197 2.12352
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.12278
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.12149
PCDHGB5 protocadherin gamma subfamily B, 5 2.12028
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 2.11622
CCDC70 coiled-coil domain containing 70 2.11566
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.10899
KRT19 keratin 19, type I 2.10178
GJC2 gap junction protein, gamma 2, 47kDa 2.09885
PAX1 paired box 1 2.08716
STC2 stanniocalcin 2 2.08456
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 2.0739
KLF1 Kruppel-like factor 1 (erythroid) 2.07389
IL36A interleukin 36, alpha 2.07276
IRAK4 interleukin-1 receptor-associated kinase 4 2.06752
HAS2 hyaluronan synthase 2 2.05909
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.05904
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.05598
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 2.05533
ANO1 anoctamin 1, calcium activated chloride channel 2.05465
SPTA1 spectrin, alpha, erythrocytic 1 2.05262
KRT14 keratin 14, type I 2.05007
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 2.0432
ZCWPW1 zinc finger, CW type with PWWP domain 1 2.04188
ACTL7A actin-like 7A 2.03619
TTLL3 tubulin tyrosine ligase-like family member 3 2.03511
ADAMTSL4 ADAMTS-like 4 2.03507
NCKAP1L NCK-associated protein 1-like 2.03374
TOP3B topoisomerase (DNA) III beta 2.03334
RAB3D RAB3D, member RAS oncogene family 2.02871
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2.02799
RHCE Rh blood group, CcEe antigens 2.02692
ZIM2 zinc finger, imprinted 2 2.02658
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.02616
CD5 CD5 molecule 2.02537
NUP93 nucleoporin 93kDa 2.02513
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.02398
KEL Kell blood group, metallo-endopeptidase 2.01917
PCDHA10 protocadherin alpha 10 2.01211
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.00902
OVOL1 ovo-like zinc finger 1 2.00372
HMX1 H6 family homeobox 1 2.00173
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.00069

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -6.65604
ZMIZ1 zinc finger, MIZ-type containing 1 -6.62404
DNM1L dynamin 1-like -6.52099
MRPS2 mitochondrial ribosomal protein S2 -6.48937
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.03419
PCNA proliferating cell nuclear antigen -5.64777
RPIA ribose 5-phosphate isomerase A -5.20109
GDF15 growth differentiation factor 15 -5.0
DSG2 desmoglein 2 -4.99481
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.96443
CD320 CD320 molecule -4.95334
TRIB3 tribbles pseudokinase 3 -4.89524
CCNB1 cyclin B1 -4.89154
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.833
KDM3A lysine (K)-specific demethylase 3A -4.79022
ISOC1 isochorismatase domain containing 1 -4.61805
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.60108
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.47284
GOLT1B golgi transport 1B -4.42632
MAPK13 mitogen-activated protein kinase 13 -4.21538
COG2 component of oligomeric golgi complex 2 -4.04656
HMG20B high mobility group 20B -3.79632
NVL nuclear VCP-like -3.76365
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.59724
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -3.48872
DHRS7B dehydrogenase/reductase (SDR family) member 7B -3.41476
HSPB1 heat shock 27kDa protein 1 -3.38178
PEG10 paternally expressed 10 -3.37767
RGS2 regulator of G-protein signaling 2 -3.34872
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.26787
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.22385
RPN1 ribophorin I -3.2059
STAT1 signal transducer and activator of transcription 1, 91kDa -3.14358
TES testin LIM domain protein -3.10672
LYRM4 LYR motif containing 4 -3.09516
GNAS GNAS complex locus -3.05427
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -3.00407
SLC12A8 solute carrier family 12, member 8 -2.99988
PDCD5 programmed cell death 5 -2.92538
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.89789
SEC16A SEC16 homolog A (S. cerevisiae) -2.87083
MAIP1 matrix AAA peptidase interacting protein 1 -2.84545
ITGB1BP1 integrin beta 1 binding protein 1 -2.84136
RAB33A RAB33A, member RAS oncogene family -2.80103
TLCD3A TLC domain containing 3A -2.78426
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.74385
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.71228
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -2.67858
RAI14 retinoic acid induced 14 -2.62832
NELL1 NEL-like 1 (chicken) -2.62311
PAK1IP1 PAK1 interacting protein 1 -2.60058
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.59964
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough -2.56288
NGRN neugrin, neurite outgrowth associated -2.55455
FHOD1 formin homology 2 domain containing 1 -2.52431
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.4484
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -2.44557
RPL26L1 ribosomal protein L26-like 1 -2.43241
MORC4 MORC family CW-type zinc finger 4 -2.37371
CNBP CCHC-type zinc finger, nucleic acid binding protein -2.36812
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.36426
PRSS8 protease, serine, 8 -2.32424
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -2.29627
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.28558
TBCB tubulin folding cofactor B -2.26113
HSPE1 heat shock 10kDa protein 1 -2.25006
PFDN2 prefoldin subunit 2 -2.24602
SCAP SREBF chaperone -2.24242
MRPL37 mitochondrial ribosomal protein L37 -2.22774
ATOX1 antioxidant 1 copper chaperone -2.21802
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.20689
ZCCHC2 zinc finger, CCHC domain containing 2 -2.1944
PLA2G12A phospholipase A2, group XIIA -2.19062
NUAK1 NUAK family, SNF1-like kinase, 1 -2.18755
YIPF1 Yip1 domain family, member 1 -2.16966
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.16633
MRM3 mitochondrial rRNA methyltransferase 3 -2.16597
NOL7 nucleolar protein 7, 27kDa -2.16311
MED24 mediator complex subunit 24 -2.15218
LOC124907782 dual specificity protein phosphatase 22 -2.15107
MFF mitochondrial fission factor -2.15001
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.14239
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -2.12235
H1-4 H1.4 linker histone, cluster member -2.12191
CD200 CD200 molecule -2.12022
MTX2 metaxin 2 -2.11284
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.09672
RAI1 retinoic acid induced 1 -2.08951
MRPS15 mitochondrial ribosomal protein S15 -2.08211
ZNF146 zinc finger protein 146 -2.0787
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -2.07337
SPATS2 spermatogenesis associated, serine-rich 2 -2.07212
CUTA cutA divalent cation tolerance homolog (E. coli) -2.07201
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -2.07033
CERS4 ceramide synthase 4 -2.04674
EGF epidermal growth factor -2.0447
USP39 ubiquitin specific peptidase 39 -2.02284
YARS1 tyrosyl-tRNA synthetase 1 -2.02178
GLRX2 glutaredoxin 2 -2.0193
FADS2 fatty acid desaturase 2 -2.00437
HSPA1B heat shock 70kDa protein 1B -2.0027
FLCN folliculin -2.00177