CRCGN014_HEPG2_24H:I20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isoniazid 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN014_HEPG2_24H:I20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.27304
STIMATE STIM activating enhancer 4.42075
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.92798
FZD7 frizzled class receptor 7 3.62551
CHN1 chimerin 1 3.51413
MAMLD1 mastermind-like domain containing 1 3.28529
UBQLN2 ubiquilin 2 3.12702
CIAO3 cytosolic iron-sulfur assembly component 3 3.00906
AMDHD2 amidohydrolase domain containing 2 3.00355
CHMP6 charged multivesicular body protein 6 2.72893
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.69096
PLSCR3 phospholipid scramblase 3 2.58258
CXCL2 chemokine (C-X-C motif) ligand 2 2.48481
KIF20A kinesin family member 20A 2.45124
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.31895
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.31715
HOXA10 homeobox A10 2.2532
LCN2 lipocalin 2 2.21108
DIPK1A divergent protein kinase domain 1A 2.20591
IFI44L interferon-induced protein 44-like 2.09944
IFI6 interferon, alpha-inducible protein 6 2.09925
SFTPB surfactant protein B 2.06886

decreased expression

Symbol Name Standardized Value
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -5.34371
CDC20 cell division cycle 20 -4.46725
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.99777
GNAS GNAS complex locus -2.6977
LDHD lactate dehydrogenase D -2.44103
PEG10 paternally expressed 10 -2.43885
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.30088
RFC2 replication factor C (activator 1) 2, 40kDa -2.23311
EGF epidermal growth factor -2.03784