CRCGN014_HEPG2_24H:I21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosopiperidine 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN014_HEPG2_24H:I21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 6.6727
PPARG peroxisome proliferator-activated receptor gamma 5.78209
MAP7 microtubule-associated protein 7 3.87415
GARRE1 granule associated Rac and RHOG effector 1 3.62517
UBQLN2 ubiquilin 2 3.57542
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.50651
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.38591
E2F2 E2F transcription factor 2 3.35084
MAMLD1 mastermind-like domain containing 1 3.15826
MSRA methionine sulfoxide reductase A 3.14417
BZW2 basic leucine zipper and W2 domains 2 3.13588
GPER1 G protein-coupled estrogen receptor 1 3.07341
CIAO3 cytosolic iron-sulfur assembly component 3 3.03431
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.02238
GATA3 GATA binding protein 3 2.86523
STK10 serine/threonine kinase 10 2.75718
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.71114
JADE2 jade family PHD finger 2 2.68907
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.64097
PLP1 proteolipid protein 1 2.59416
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.56043
STAP2 signal transducing adaptor family member 2 2.44937
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.40899
KIFBP kinesin family binding protein 2.39303
CGRRF1 cell growth regulator with ring finger domain 1 2.3735
CHN1 chimerin 1 2.31006
ABHD6 abhydrolase domain containing 6 2.30021
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.28018
COPS7A COP9 signalosome subunit 7A 2.26591
ZBTB7C zinc finger and BTB domain containing 7C 2.25792
PEX11A peroxisomal biogenesis factor 11 alpha 2.24823
MOK MOK protein kinase 2.2429
EPHA3 EPH receptor A3 2.18431
MCM3 minichromosome maintenance complex component 3 2.17736
FZD7 frizzled class receptor 7 2.174
DOCK2 dedicator of cytokinesis 2 2.16786
POU3F4 POU class 3 homeobox 4 2.14739
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.1269
DYNLT3 dynein, light chain, Tctex-type 3 2.1053
LYN LYN proto-oncogene, Src family tyrosine kinase 2.10214
PRR15L proline rich 15-like 2.07804
GUCA2B guanylate cyclase activator 2B (uroguanylin) 2.05985
CINP cyclin-dependent kinase 2 interacting protein 2.04624
FSHR follicle stimulating hormone receptor 2.03851
TPO thyroid peroxidase 2.0379
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.00381
ZBTB3 zinc finger and BTB domain containing 3 2.00125

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -5.14781
ZNF586 zinc finger protein 586 -4.10084
LOC124907782 dual specificity protein phosphatase 22 -3.99273
PCNA proliferating cell nuclear antigen -3.92172
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.49301
ZMIZ1 zinc finger, MIZ-type containing 1 -3.44728
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -3.30465
TUBB6 tubulin, beta 6 class V -3.29341
TM9SF3 transmembrane 9 superfamily member 3 -3.28397
FGFR4 fibroblast growth factor receptor 4 -3.27675
C2CD5 C2 calcium-dependent domain containing 5 -3.26483
CCDC86 coiled-coil domain containing 86 -3.09765
FBXL12 F-box and leucine-rich repeat protein 12 -2.96071
KDM3A lysine (K)-specific demethylase 3A -2.95419
CDC20 cell division cycle 20 -2.93142
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.87173
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -2.80459
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.75515
PRPF4 pre-mRNA processing factor 4 -2.70112
TSPAN4 tetraspanin 4 -2.63884
DSG2 desmoglein 2 -2.5295
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.52659
DNM1L dynamin 1-like -2.46673
GOLT1B golgi transport 1B -2.33018
TBCB tubulin folding cofactor B -2.15025
YME1L1 YME1-like 1 ATPase -2.11109
TRAP1 TNF receptor-associated protein 1 -2.00545