CRCGN014_HEPG2_24H:J01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-cresidine 38.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

109 genes differentially expressed following the CRCGN014_HEPG2_24H:J01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 9.54297
CXCL2 chemokine (C-X-C motif) ligand 2 7.43946
ADGRE5 adhesion G protein-coupled receptor E5 5.32216
KLHL21 kelch-like family member 21 5.22242
SQOR sulfide quinone oxidoreductase 5.11465
EGF epidermal growth factor 4.8922
E2F2 E2F transcription factor 2 4.82959
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.78925
CYCS cytochrome c, somatic 4.77145
ADRB2 adrenoceptor beta 2, surface 4.54157
C2CD2 C2 calcium-dependent domain containing 2 4.51446
MAP7 microtubule-associated protein 7 3.83339
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.80837
PPARG peroxisome proliferator-activated receptor gamma 3.67926
VAV3 vav 3 guanine nucleotide exchange factor 3.55068
CGRRF1 cell growth regulator with ring finger domain 1 3.37253
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.28387
ABHD6 abhydrolase domain containing 6 3.27261
TIAM1 T-cell lymphoma invasion and metastasis 1 3.23045
PRKCH protein kinase C, eta 3.20298
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.16789
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.88877
CHN1 chimerin 1 2.8846
SATB1 SATB homeobox 1 2.79203
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.69193
CHMP6 charged multivesicular body protein 6 2.6743
GPATCH8 G patch domain containing 8 2.67294
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 2.62104
CD40 CD40 molecule, TNF receptor superfamily member 5 2.61116
EFHD2 EF-hand domain family, member D2 2.60758
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.60745
CXCL5 chemokine (C-X-C motif) ligand 5 2.6018
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.57731
TRAM2 translocation associated membrane protein 2 2.44221
PRR15L proline rich 15-like 2.37321
TPD52L2 tumor protein D52-like 2 2.33246
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.29815
ENOPH1 enolase-phosphatase 1 2.29408
STIMATE STIM activating enhancer 2.28565
PDLIM1 PDZ and LIM domain 1 2.28379
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 2.26671
IQGAP1 IQ motif containing GTPase activating protein 1 2.1848
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.17718
HDAC2 histone deacetylase 2 2.14071
RPS26 ribosomal protein S26 2.13235
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.10943
DIO3 deiodinase, iodothyronine, type III 2.10898
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.10466
CHEK2 checkpoint kinase 2 2.10337
SNX17 sorting nexin 17 2.08646
RBM47 RNA binding motif protein 47 2.08623
GPER1 G protein-coupled estrogen receptor 1 2.08356
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.06025
NCSTN nicastrin 2.04225
PARP1 poly (ADP-ribose) polymerase 1 2.03903
FLT3 fms-related tyrosine kinase 3 2.02254
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.02116
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.01743
COL6A3 collagen, type VI, alpha 3 2.00885

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -5.11807
KDM3A lysine (K)-specific demethylase 3A -5.10384
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.01558
THAP11 THAP domain containing 11 -4.99139
NGRN neugrin, neurite outgrowth associated -4.91466
COG2 component of oligomeric golgi complex 2 -4.88698
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.76283
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.5495
CD320 CD320 molecule -4.51666
LDHD lactate dehydrogenase D -4.43832
MRPS2 mitochondrial ribosomal protein S2 -4.35494
TRIB3 tribbles pseudokinase 3 -4.24599
NIPSNAP1 nipsnap homolog 1 (C. elegans) -3.91075
ILK integrin-linked kinase -3.73997
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.65302
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.5824
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.33122
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.25379
MTA1 metastasis associated 1 -3.06321
SNX11 sorting nexin 11 -2.8388
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.69685
PCNA proliferating cell nuclear antigen -2.64955
CLNS1A chloride channel, nucleotide-sensitive, 1A -2.63137
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.62522
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.61898
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -2.54575
PECR peroxisomal trans-2-enoyl-CoA reductase -2.53206
FKBP4 FK506 binding protein 4, 59kDa -2.43999
EIF5 eukaryotic translation initiation factor 5 -2.42071
FOS FBJ murine osteosarcoma viral oncogene homolog -2.41769
CHIC2 cysteine-rich hydrophobic domain 2 -2.3117
IL1RAP interleukin 1 receptor accessory protein -2.29842
TRAF5 TNF receptor-associated factor 5 -2.29516
SLC26A6 solute carrier family 26 (anion exchanger), member 6 -2.29255
CCNH cyclin H -2.28663
NOL8 nucleolar protein 8 -2.27917
HMG20B high mobility group 20B -2.2572
CUX2 cut-like homeobox 2 -2.23778
GNAS GNAS complex locus -2.23681
NCF4 neutrophil cytosolic factor 4, 40kDa -2.19772
ADI1 acireductone dioxygenase 1 -2.17081
GCC2 GRIP and coiled-coil domain containing 2 -2.1455
PHACTR1 phosphatase and actin regulator 1 -2.12755
MLF2 myeloid leukemia factor 2 -2.09391
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.07239
LOC102724560 cystathionine beta-synthase -2.06956
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -2.04669
SUGCT succinyl-CoA:glutarate-CoA transferase -2.03792
CENPU centromere protein U -2.02693
H2BC5 H2B clustered histone 5 -2.02666