CRCGN014_HEPG2_24H:J03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(e)-(4-sulfonatophenyl)diazenyl]-2,5-dihydro-1h-pyrazole-3-carboxylate 20.58 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

109 genes differentially expressed following the CRCGN014_HEPG2_24H:J03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BACE2 beta-site APP-cleaving enzyme 2 10.0
CXCL2 chemokine (C-X-C motif) ligand 2 4.8569
RPL39L ribosomal protein L39-like 4.8347
CCDC92 coiled-coil domain containing 92 4.801
GHR growth hormone receptor 4.7437
ATP11B ATPase, class VI, type 11B 4.6767
MOK MOK protein kinase 4.6429
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.5463
MEF2C myocyte enhancer factor 2C 4.49252
LCN2 lipocalin 2 4.45435
ANO10 anoctamin 10 4.3317
AXIN1 axin 1 4.0362
JADE2 jade family PHD finger 2 4.03403
RRAGA Ras-related GTP binding A 4.0122
CYCS cytochrome c, somatic 3.9637
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.87275
ABHD6 abhydrolase domain containing 6 3.55795
TXNL4B thioredoxin-like 4B 3.54105
MEST mesoderm specific transcript 3.4994
MUC1 mucin 1, cell surface associated 3.29463
PPARG peroxisome proliferator-activated receptor gamma 3.09
CREB1 cAMP responsive element binding protein 1 3.06836
HAT1 histone acetyltransferase 1 2.96925
ZBTB35 zinc finger and BTB domain containing 35 2.913
RXYLT1 ribitol xylosyltransferase 1 2.87758
CSK c-src tyrosine kinase 2.7909
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.77875
PLSCR3 phospholipid scramblase 3 2.76807
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.67275
KIFBP kinesin family binding protein 2.6445
TBP TATA box binding protein 2.6178
TRAPPC6A trafficking protein particle complex 6A 2.53755
LOC122526780 uncharacterized LOC122526780 2.42765
SCRN1 secernin 1 2.3947
DYNLL1 dynein, light chain, LC8-type 1 2.29325
MPC1 mitochondrial pyruvate carrier 1 2.25715
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.2541
FFAR1 free fatty acid receptor 1 2.22982
CCDC85B coiled-coil domain containing 85B 2.2159
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.2086
RPA3 replication protein A3, 14kDa 2.16735
PYCR1 pyrroline-5-carboxylate reductase 1 2.16735
CDPF1 cysteine-rich, DPF motif domain containing 1 2.1362
RTL8C retrotransposon Gag like 8C 2.11665
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 2.0607
KRT23 keratin 23, type I 2.0387
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.03475
JUP junction plakoglobin 2.03005
STIMATE STIM activating enhancer 2.0213
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 2.01865
MARCKSL1 MARCKS-like 1 2.01245

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.80115
TM9SF3 transmembrane 9 superfamily member 3 -5.7372
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.38595
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.35315
SLC35F2 solute carrier family 35, member F2 -5.2839
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.0
CCNB1 cyclin B1 -4.929
COG4 component of oligomeric golgi complex 4 -4.81805
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.7322
GTPBP8 GTP-binding protein 8 (putative) -4.7298
THAP11 THAP domain containing 11 -4.72355
FASTKD5 FAST kinase domains 5 -4.59675
FBXL12 F-box and leucine-rich repeat protein 12 -4.0539
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -3.91195
ZW10 zw10 kinetochore protein -3.8929
BLMH bleomycin hydrolase -3.47975
CAB39 calcium binding protein 39 -3.41685
CDC25B cell division cycle 25B -3.29935
TLR4 toll-like receptor 4 -3.2389
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.21845
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -3.2003
DYNLT3 dynein, light chain, Tctex-type 3 -3.1709
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.09005
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -3.08165
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.88295
TM9SF2 transmembrane 9 superfamily member 2 -2.877
EIF5 eukaryotic translation initiation factor 5 -2.85071
TOMM70 translocase of outer mitochondrial membrane 70 -2.81055
MCOLN1 mucolipin 1 -2.72765
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.68985
ZMIZ1 zinc finger, MIZ-type containing 1 -2.667
LOC124907782 dual specificity protein phosphatase 22 -2.6529
GNAS GNAS complex locus -2.63931
ANKRD10 ankyrin repeat domain 10 -2.63045
CRYZ crystallin, zeta (quinone reductase) -2.5809
TBX3 T-box 3 -2.5198
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.4618
FES FES proto-oncogene, tyrosine kinase -2.3703
ITK IL2-inducible T-cell kinase -2.33555
RGS16 regulator of G-protein signaling 16 -2.28722
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.262
TRIM52 tripartite motif containing 52 -2.244
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.22793
CARD9 caspase recruitment domain family, member 9 -2.2066
AKAP8 A kinase (PRKA) anchor protein 8 -2.20637
BLVRA biliverdin reductase A -2.20165
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -2.1828
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.1321
PRKCD protein kinase C, delta -2.11995
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.0972
ZNF813 zinc finger protein 813 -2.07915
ZC3H4 zinc finger CCCH-type containing 4 -2.06265
SERF1A small EDRK-rich factor 1A (telomeric) -2.05875
GALT galactose-1-phosphate uridylyltransferase -2.04845
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -2.0475
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.0424
RPS5 ribosomal protein S5 -2.0289
TRIB1 tribbles pseudokinase 1 -2.01145