CRCGN014_HEPG2_24H:J05 Gene Set
Dataset
Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category
transcriptomics
Type
small molecule perturbation
Description
(3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 21.08 um perturbation at 24 h in HEPG2 (Carcinogenome )
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Genes
34 genes differentially expressed following the CRCGN014_HEPG2_24H:J05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
increased expression
Symbol
Name
Standardized Value
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
6.53931
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
3.58142
KCNK1
potassium channel, two pore domain subfamily K, member 1
3.40562
SMARCD2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
3.20334
CHMP6
charged multivesicular body protein 6
3.11693
ADRB2
adrenoceptor beta 2, surface
2.98861
CIAO3
cytosolic iron-sulfur assembly component 3
2.97384
ANO1
anoctamin 1, calcium activated chloride channel
2.93849
HDGFL3
HDGF like 3
2.78831
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
2.77695
NUDT9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
2.70549
EPHA3
EPH receptor A3
2.68692
PMM2
phosphomannomutase 2
2.42772
GPER1
G protein-coupled estrogen receptor 1
2.41812
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
2.27081
VTA1
vesicle (multivesicular body) trafficking 1
2.1585
PEX11A
peroxisomal biogenesis factor 11 alpha
2.08704
decreased expression
Symbol
Name
Standardized Value
PCNA
proliferating cell nuclear antigen
-5.07634
RAI14
retinoic acid induced 14
-3.68252
ZMIZ1
zinc finger, MIZ-type containing 1
-3.4832
POLR2I
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
-3.27007
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
-3.24218
ISOC1
isochorismatase domain containing 1
-3.14431
FASTKD5
FAST kinase domains 5
-3.02993
FIS1
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
-2.99469
CDC20
cell division cycle 20
-2.96052
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
-2.51834
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
-2.4382
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
-2.3061
PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
-2.29023
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
-2.17591
SNX11
sorting nexin 11
-2.17146
KCNK5
potassium channel, two pore domain subfamily K, member 5
-2.10845
TENT4A
terminal nucleotidyltransferase 4A
-2.01961
