CRCGN014_HEPG2_24H:J06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-nitropropanoic acid 21.83 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN014_HEPG2_24H:J06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 4.27397
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.62461
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.50291
ABHD4 abhydrolase domain containing 4 3.49343
HOXA10 homeobox A10 3.14981
BLMH bleomycin hydrolase 3.1489
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.11902
DIPK1A divergent protein kinase domain 1A 3.03981
PEX11A peroxisomal biogenesis factor 11 alpha 2.93235
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.89357
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.71899
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.39621
SAA4 serum amyloid A4, constitutive 2.15295
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.12427
NMU neuromedin U 2.12216
VAV3 vav 3 guanine nucleotide exchange factor 2.07316
CSK c-src tyrosine kinase 2.07087
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.06762

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -7.56868
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.8796
C2CD5 C2 calcium-dependent domain containing 5 -3.79853
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.62127
PEG10 paternally expressed 10 -3.52748
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.40136
NUP85 nucleoporin 85kDa -3.30297
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.07099
CD320 CD320 molecule -3.02725
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.71946
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.65502
LDHD lactate dehydrogenase D -2.49636
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.36502
RAI14 retinoic acid induced 14 -2.26221
ZSCAN18 zinc finger and SCAN domain containing 18 -2.06073