CRCGN014_HEPG2_24H:J08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN014_HEPG2_24H:J08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 3.74889
STAP2 signal transducing adaptor family member 2 3.27454
DYNLT3 dynein, light chain, Tctex-type 3 3.07878
PLSCR1 phospholipid scramblase 1 2.94666
TREM1 triggering receptor expressed on myeloid cells 1 2.90465
CARMIL1 capping protein regulator and myosin 1 linker 1 2.8768
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.84649
MYLK myosin light chain kinase 2.8109
PLS1 plastin 1 2.5631
CXCL2 chemokine (C-X-C motif) ligand 2 2.42879
CCDC85B coiled-coil domain containing 85B 2.37217
NENF neudesin neurotrophic factor 2.27877
CDPF1 cysteine-rich, DPF motif domain containing 1 2.23829
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.10851
CEP57 centrosomal protein 57kDa 2.05218

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.92542
RNF167 ring finger protein 167 -3.13444
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.08478
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.07663
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.0691
LDHD lactate dehydrogenase D -2.98357
ACOT9 acyl-CoA thioesterase 9 -2.97095
PCNA proliferating cell nuclear antigen -2.8188
GTPBP8 GTP-binding protein 8 (putative) -2.73941
SLC35F2 solute carrier family 35, member F2 -2.48414
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -2.41483
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.2416
RAI14 retinoic acid induced 14 -2.18238
ANKRD10 ankyrin repeat domain 10 -2.16485
GNAS GNAS complex locus -2.16471
OXA1L oxidase (cytochrome c) assembly 1-like -2.16161
TCERG1 transcription elongation regulator 1 -2.10807
TLCD3A TLC domain containing 3A -2.0971
CDC25B cell division cycle 25B -2.00518