| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | sodium 4-((e)-{5-methoxy-4-[(e)-(4-methoxyphenyl)diazenyl]-2-methylphenyl}diazenyl)benzenesulfonate 20.33 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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75 genes differentially expressed following the CRCGN014_HEPG2_24H:J09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| E2F2 | E2F transcription factor 2 | 9.35271 |
| UBQLN2 | ubiquilin 2 | 9.33728 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 6.89671 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.8599 |
| CHMP6 | charged multivesicular body protein 6 | 4.81719 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.74644 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 4.23352 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 4.18627 |
| KIFBP | kinesin family binding protein | 3.93933 |
| FCHO1 | FCH domain only 1 | 3.83522 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 3.63307 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.37312 |
| ABHD6 | abhydrolase domain containing 6 | 3.16528 |
| ADAM10 | ADAM metallopeptidase domain 10 | 3.16264 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.0094 |
| CDK19 | cyclin-dependent kinase 19 | 2.71898 |
| CYCS | cytochrome c, somatic | 2.69414 |
| ZNF589 | zinc finger protein 589 | 2.65302 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.63003 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.60735 |
| JADE2 | jade family PHD finger 2 | 2.60275 |
| PIH1D1 | PIH1 domain containing 1 | 2.5085 |
| CSK | c-src tyrosine kinase | 2.38318 |
| B3GNT4 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 | 2.35821 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 2.34682 |
| VGLL4 | vestigial-like family member 4 | 2.34353 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.30587 |
| COPS7A | COP9 signalosome subunit 7A | 2.29899 |
| GPR31 | G protein-coupled receptor 31 | 2.26721 |
| VAT1 | vesicle amine transport 1 | 2.25603 |
| ST8SIA2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | 2.2434 |
| CHN1 | chimerin 1 | 2.24162 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.15016 |
| GJA3 | gap junction protein, alpha 3, 46kDa | 2.11918 |
| NADSYN1 | NAD synthetase 1 | 2.11822 |
| PDCD6 | programmed cell death 6 | 2.10797 |
| RPS6KA6 | ribosomal protein S6 kinase, 90kDa, polypeptide 6 | 2.09054 |
| BGLAP | bone gamma-carboxyglutamate (gla) protein | 2.06919 |
| GBX2 | gastrulation brain homeobox 2 | 2.06553 |
| APEH | acylaminoacyl-peptide hydrolase | 2.03996 |
| KCNQ4 | potassium channel, voltage gated KQT-like subfamily Q, member 4 | 2.00382 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -5.20795 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.67044 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -4.58198 |
| FAIM | Fas apoptotic inhibitory molecule | -4.57772 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -4.52505 |
| LDHD | lactate dehydrogenase D | -4.38219 |
| RHEB | Ras homolog enriched in brain | -4.17249 |
| HMG20B | high mobility group 20B | -3.94356 |
| SNX11 | sorting nexin 11 | -3.4783 |
| NGRN | neugrin, neurite outgrowth associated | -3.16871 |
| DERA | deoxyribose-phosphate aldolase (putative) | -3.11652 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.78377 |
| APIP | APAF1 interacting protein | -2.76081 |
| PDHX | pyruvate dehydrogenase complex, component X | -2.66101 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.58899 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.4006 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -2.36825 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | -2.36439 |
| TEX30 | testis expressed 30 | -2.30798 |
| CCNB2 | cyclin B2 | -2.28254 |
| MSRB1 | methionine sulfoxide reductase B1 | -2.2148 |
| NUP58 | nucleoporin 58 | -2.21147 |
| DNAJC24 | DnaJ (Hsp40) homolog, subfamily C, member 24 | -2.20651 |
| KCMF1 | potassium channel modulatory factor 1 | -2.18533 |
| METTL22 | methyltransferase like 22 | -2.15341 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.15046 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -2.14962 |
| HTRA2 | HtrA serine peptidase 2 | -2.13348 |
| NAT10 | N-acetyltransferase 10 (GCN5-related) | -2.09035 |
| PAM16 | presequence translocase-associated motor 16 homolog (S. cerevisiae) | -2.07407 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.06456 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -2.0386 |
| SNRNP27 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5) | -2.03482 |
| DPF2 | D4, zinc and double PHD fingers family 2 | -2.01939 |
