CRCGN014_HEPG2_24H:J17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxymetholone 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

85 genes differentially expressed following the CRCGN014_HEPG2_24H:J17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 7.05622
TXNRD1 thioredoxin reductase 1 6.10259
ABHD6 abhydrolase domain containing 6 5.63235
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.62514
PPARG peroxisome proliferator-activated receptor gamma 5.43645
ABHD4 abhydrolase domain containing 4 4.47425
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.9879
CHN1 chimerin 1 3.80202
CNPY3 canopy FGF signaling regulator 3 3.68022
CBR1 carbonyl reductase 1 3.67671
ADRB2 adrenoceptor beta 2, surface 3.62755
PRR15L proline rich 15-like 3.61898
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.55949
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.35199
ATP11B ATPase, class VI, type 11B 3.22132
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.16912
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.12308
SFTPB surfactant protein B 3.08996
NPDC1 neural proliferation, differentiation and control, 1 3.07582
SQSTM1 sequestosome 1 3.04929
GPC1 glypican 1 2.73102
UGDH UDP-glucose 6-dehydrogenase 2.62869
IDE insulin-degrading enzyme 2.60025
KEAP1 kelch-like ECH-associated protein 1 2.59227
ALAS1 5'-aminolevulinate synthase 1 2.53881
DIPK1A divergent protein kinase domain 1A 2.50948
FOSL1 FOS-like antigen 1 2.4431
HMOX1 heme oxygenase 1 2.35217
FKBP14 FK506 binding protein 14, 22 kDa 2.34828
TRIM16 tripartite motif containing 16 2.34124
MYLK myosin light chain kinase 2.337
TUBB6 tubulin, beta 6 class V 2.30193
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.28715
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.27924
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.25813
GCLM glutamate-cysteine ligase, modifier subunit 2.1567
YARS1 tyrosyl-tRNA synthetase 1 2.15091
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.14854
CD40 CD40 molecule, TNF receptor superfamily member 5 2.11959
CCNF cyclin F 2.09479
TRIB1 tribbles pseudokinase 1 2.09423
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.08976
NANOS3 nanos homolog 3 (Drosophila) 2.08048
GLRX glutaredoxin (thioltransferase) 2.05928
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.01334
PEX11A peroxisomal biogenesis factor 11 alpha 2.00858

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.31589
CCNB1 cyclin B1 -6.68258
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.21096
PSRC1 proline/serine-rich coiled-coil 1 -4.20868
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.84816
RPIA ribose 5-phosphate isomerase A -3.61764
LDHD lactate dehydrogenase D -3.45818
UBE2C ubiquitin-conjugating enzyme E2C -3.38874
CCNB2 cyclin B2 -3.28886
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.23428
THAP11 THAP domain containing 11 -3.19274
ICAM3 intercellular adhesion molecule 3 -3.14499
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.09929
TOP2A topoisomerase (DNA) II alpha 170kDa -2.97074
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.96498
C5 complement component 5 -2.8416
CDK1 cyclin-dependent kinase 1 -2.83989
CCNA2 cyclin A2 -2.81286
SCAND1 SCAN domain containing 1 -2.81258
CDC20 cell division cycle 20 -2.77095
CDC25B cell division cycle 25B -2.69459
RPS5 ribosomal protein S5 -2.65826
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.54
PLK1 polo-like kinase 1 -2.51837
NCAPD2 non-SMC condensin I complex, subunit D2 -2.46374
PGM1 phosphoglucomutase 1 -2.45711
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.43211
GNAS GNAS complex locus -2.40093
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.37573
AURKB aurora kinase B -2.34896
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.3439
S100A4 S100 calcium binding protein A4 -2.27818
PHYH phytanoyl-CoA 2-hydroxylase -2.27744
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.22145
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.18746
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.11279
OXSR1 oxidative stress responsive 1 -2.07956
PECR peroxisomal trans-2-enoyl-CoA reductase -2.03794
CHL1 cell adhesion molecule L1-like -2.03175