CRCGN014_HEPG2_24H:J19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethindrone 20.56 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN014_HEPG2_24H:J19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.65138
LCN2 lipocalin 2 5.14807
TIMP2 TIMP metallopeptidase inhibitor 2 3.81493
CHMP6 charged multivesicular body protein 6 3.05348
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.99093
HLA-DRA major histocompatibility complex, class II, DR alpha 2.9855
RRAGA Ras-related GTP binding A 2.83675
ATP11B ATPase, class VI, type 11B 2.81514
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.6137
CHN1 chimerin 1 2.57162
NPDC1 neural proliferation, differentiation and control, 1 2.54525
EVL Enah/Vasp-like 2.54118
MTERF3 mitochondrial transcription termination factor 3 2.50708
STK10 serine/threonine kinase 10 2.4982
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.21151
NOSIP nitric oxide synthase interacting protein 2.19379
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.17514
CNPY3 canopy FGF signaling regulator 3 2.12647
SQOR sulfide quinone oxidoreductase 2.12545
UGDH UDP-glucose 6-dehydrogenase 2.09309
MVP major vault protein 2.07058
ABHD4 abhydrolase domain containing 4 2.04645
INPP1 inositol polyphosphate-1-phosphatase 2.01608
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.01296

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -5.15165
ISOC1 isochorismatase domain containing 1 -4.01275
DNM1L dynamin 1-like -4.00502
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.6054
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.53109
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.40611
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.24782
TSPAN4 tetraspanin 4 -3.22586
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.95725
TEX10 testis expressed 10 -2.90947
PDHX pyruvate dehydrogenase complex, component X -2.8701
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.83204
LDHD lactate dehydrogenase D -2.81895
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.75155
PLK1 polo-like kinase 1 -2.73973
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.68782
TUBB6 tubulin, beta 6 class V -2.66196
COG4 component of oligomeric golgi complex 4 -2.63489
PSRC1 proline/serine-rich coiled-coil 1 -2.53474
TLR4 toll-like receptor 4 -2.48801
ZNF586 zinc finger protein 586 -2.47685
SNX11 sorting nexin 11 -2.39666
ARID5B AT rich interactive domain 5B (MRF1-like) -2.39504
CDC25B cell division cycle 25B -2.34955
INCENP inner centromere protein antigens 135/155kDa -2.3122
PPOX protoporphyrinogen oxidase -2.26552
TOP2A topoisomerase (DNA) II alpha 170kDa -2.24597
RIMS1 regulating synaptic membrane exocytosis 1 -2.24527
LBR lamin B receptor -2.19755
NCAPD2 non-SMC condensin I complex, subunit D2 -2.17672
TRAIP TRAF interacting protein -2.16024
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -2.15771
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.14644
BIRC5 baculoviral IAP repeat containing 5 -2.11163
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.07323
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 -2.02445
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.00276