CRCGN014_HEPG2_24H:J24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description potassium 1h-indol-3-yl sulfate 21.71 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

141 genes differentially expressed following the CRCGN014_HEPG2_24H:J24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 7.73769
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.86395
VAT1 vesicle amine transport 1 5.7061
HMOX1 heme oxygenase 1 5.12665
GPER1 G protein-coupled estrogen receptor 1 4.88902
CXCL2 chemokine (C-X-C motif) ligand 2 4.79156
ABHD4 abhydrolase domain containing 4 4.52115
TIMP2 TIMP metallopeptidase inhibitor 2 4.42584
CYTH1 cytohesin 1 4.37819
CNPY3 canopy FGF signaling regulator 3 4.22144
ALAS1 5'-aminolevulinate synthase 1 3.94082
SQOR sulfide quinone oxidoreductase 3.93401
ZFP36 ZFP36 ring finger protein 3.85939
CGRRF1 cell growth regulator with ring finger domain 1 3.84942
FOSL1 FOS-like antigen 1 3.75512
UBQLN2 ubiquilin 2 3.72319
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 3.71132
UGDH UDP-glucose 6-dehydrogenase 3.6825
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.67966
SFTPB surfactant protein B 3.63144
LPGAT1 lysophosphatidylglycerol acyltransferase 1 3.60002
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.59092
ADGRE5 adhesion G protein-coupled receptor E5 3.56632
RAP1GAP RAP1 GTPase activating protein 3.48128
KEAP1 kelch-like ECH-associated protein 1 3.42842
MVP major vault protein 3.3955
RSU1 Ras suppressor protein 1 3.20871
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.19599
LSR lipolysis stimulated lipoprotein receptor 3.09723
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.05341
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.04548
PNKP polynucleotide kinase 3'-phosphatase 3.0335
GATA2 GATA binding protein 2 3.02696
CAB39 calcium binding protein 39 3.02461
ADRB2 adrenoceptor beta 2, surface 2.93629
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.84482
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.83104
MINDY1 MINDY lysine 48 deubiquitinase 1 2.7949
SQSTM1 sequestosome 1 2.78511
SOCS2 suppressor of cytokine signaling 2 2.77372
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.77217
INPP1 inositol polyphosphate-1-phosphatase 2.68183
OSGIN1 oxidative stress induced growth inhibitor 1 2.64377
NUCB2 nucleobindin 2 2.46923
UBE2A ubiquitin-conjugating enzyme E2A 2.46502
NANOS3 nanos homolog 3 (Drosophila) 2.46413
DYNLT3 dynein, light chain, Tctex-type 3 2.45512
RRAGA Ras-related GTP binding A 2.45228
RALB v-ral simian leukemia viral oncogene homolog B 2.43233
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.3862
PMM2 phosphomannomutase 2 2.3833
CTSL cathepsin L 2.37553
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.36692
EPHB2 EPH receptor B2 2.32079
STAP2 signal transducing adaptor family member 2 2.31918
STIMATE STIM activating enhancer 2.31393
SMAD3 SMAD family member 3 2.29491
GCLM glutamate-cysteine ligase, modifier subunit 2.29382
E2F2 E2F transcription factor 2 2.24476
KIFBP kinesin family binding protein 2.20437
CDC25B cell division cycle 25B 2.19016
KLHL21 kelch-like family member 21 2.18394
CDPF1 cysteine-rich, DPF motif domain containing 1 2.17014
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.13088
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.12284
CCP110 centriolar coiled coil protein 110kDa 2.10738
GPC1 glypican 1 2.08343
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.08271
SORBS3 sorbin and SH3 domain containing 3 2.07824
CBR1 carbonyl reductase 1 2.07214
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.06083
PFKL phosphofructokinase, liver 2.04601
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.03507
HDGFL3 HDGF like 3 2.01772
TP53I3 tumor protein p53 inducible protein 3 2.00003

decreased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 -6.48105
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.46554
FGFR4 fibroblast growth factor receptor 4 -5.17802
PSRC1 proline/serine-rich coiled-coil 1 -5.14637
ISOC1 isochorismatase domain containing 1 -4.73957
PECR peroxisomal trans-2-enoyl-CoA reductase -4.68347
C5 complement component 5 -4.50414
CDK1 cyclin-dependent kinase 1 -3.77445
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.64471
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.50793
CCNA2 cyclin A2 -3.46717
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.45593
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.41837
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.351
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.27579
PLK1 polo-like kinase 1 -3.26623
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.24346
ACAA1 acetyl-CoA acyltransferase 1 -3.21305
GLOD4 glyoxalase domain containing 4 -3.19161
UBE2C ubiquitin-conjugating enzyme E2C -3.11046
HMGA2 high mobility group AT-hook 2 -3.06834
NCAPD2 non-SMC condensin I complex, subunit D2 -3.05548
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.99905
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.88714
CHMP4B charged multivesicular body protein 4B -2.78713
LDHD lactate dehydrogenase D -2.77175
ALDOC aldolase C, fructose-bisphosphate -2.75356
DSG2 desmoglein 2 -2.73032
PEG10 paternally expressed 10 -2.70417
VDAC1 voltage-dependent anion channel 1 -2.68015
ENOPH1 enolase-phosphatase 1 -2.6779
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.67544
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.66345
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.56215
CDC20 cell division cycle 20 -2.5451
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.53715
AURKB aurora kinase B -2.50119
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.48238
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.41685
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.35216
MRPS2 mitochondrial ribosomal protein S2 -2.26451
TERT telomerase reverse transcriptase -2.2638
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.25839
NUP85 nucleoporin 85kDa -2.25233
TMED9 transmembrane emp24 protein transport domain containing 9 -2.21954
CCNB1 cyclin B1 -2.18474
PDCD6 programmed cell death 6 -2.17557
USP1 ubiquitin specific peptidase 1 -2.17515
MYL9 myosin, light chain 9, regulatory -2.16528
TOP2A topoisomerase (DNA) II alpha 170kDa -2.14892
LAGE3 L antigen family, member 3 -2.14179
CKS1B CDC28 protein kinase regulatory subunit 1B -2.1286
HAT1 histone acetyltransferase 1 -2.12506
BIRC5 baculoviral IAP repeat containing 5 -2.11808
CDK4 cyclin-dependent kinase 4 -2.10434
DNM1L dynamin 1-like -2.09714
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.08039
EDN1 endothelin 1 -2.07929
NT5DC2 5'-nucleotidase domain containing 2 -2.07297
PCCB propionyl CoA carboxylase, beta polypeptide -2.05116
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.03323
RNF167 ring finger protein 167 -2.02602
CCNH cyclin H -2.02073
BRD7 bromodomain containing 7 -2.01923
S100A4 S100 calcium binding protein A4 -2.00603
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.00531