CRCGN014_HEPG2_24H:K01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,6-dinitrotoluene 39.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

556 genes differentially expressed following the CRCGN014_HEPG2_24H:K01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 9.7526
OXCT1 3-oxoacid CoA transferase 1 9.50315
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 8.5772
CDPF1 cysteine-rich, DPF motif domain containing 1 7.9957
MAP7 microtubule-associated protein 7 7.1967
CXCL2 chemokine (C-X-C motif) ligand 2 7.16275
KIFBP kinesin family binding protein 6.0392
EDN1 endothelin 1 5.9567
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.93605
LPAR2 lysophosphatidic acid receptor 2 5.82975
E2F2 E2F transcription factor 2 5.6611
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.61095
LOXL1 lysyl oxidase-like 1 5.54965
TAC4 tachykinin 4 (hemokinin) 5.5188
RPP38 ribonuclease P/MRP 38kDa subunit 5.42985
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 5.26155
BACE2 beta-site APP-cleaving enzyme 2 5.19195
LCN2 lipocalin 2 5.0
HLA-DRA major histocompatibility complex, class II, DR alpha 4.97417
CCNF cyclin F 4.88748
CBR1 carbonyl reductase 1 4.8817
STX1A syntaxin 1A (brain) 4.84085
CCL2 chemokine (C-C motif) ligand 2 4.8113
JADE2 jade family PHD finger 2 4.7589
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 4.68355
LAGE3 L antigen family, member 3 4.52005
BTK Bruton agammaglobulinemia tyrosine kinase 4.49075
TIAM1 T-cell lymphoma invasion and metastasis 1 4.42292
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.31165
SNAP25 synaptosomal-associated protein, 25kDa 4.3091
LOC122526780 uncharacterized LOC122526780 4.2707
EGF epidermal growth factor 4.2604
GRWD1 glutamate-rich WD repeat containing 1 4.0672
SATB1 SATB homeobox 1 4.0372
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.02645
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.9992
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.9476
MYLK myosin light chain kinase 3.90095
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.89367
CCDC85B coiled-coil domain containing 85B 3.89055
GSTZ1 glutathione S-transferase zeta 1 3.8772
PRR15L proline rich 15-like 3.87155
INSIG1 insulin induced gene 1 3.86585
COL4A1 collagen, type IV, alpha 1 3.85092
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.84617
PEX11A peroxisomal biogenesis factor 11 alpha 3.75728
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 3.7118
FZD7 frizzled class receptor 7 3.66987
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.6604
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.6572
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.49207
TRAPPC6A trafficking protein particle complex 6A 3.4343
MZB1 marginal zone B and B1 cell-specific protein 3.37085
GET1 guided entry of tail-anchored proteins factor 1 3.3628
HDGFL3 HDGF like 3 3.28614
TREM1 triggering receptor expressed on myeloid cells 1 3.28325
CAPN1 calpain 1, (mu/I) large subunit 3.26055
GPATCH8 G patch domain containing 8 3.24985
NAP1L4 nucleosome assembly protein 1-like 4 3.24575
RBM15B RNA binding motif protein 15B 3.2332
DOK3 docking protein 3 3.2191
TSSC4 tumor suppressing subtransferable candidate 4 3.1897
FOS FBJ murine osteosarcoma viral oncogene homolog 3.18195
ATAD3A ATPase family, AAA domain containing 3A 3.17975
CER1 cerberus 1, DAN family BMP antagonist 3.1755
GDF3 growth differentiation factor 3 3.17115
FCHO1 FCH domain only 1 3.15895
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 3.152
FOXH1 forkhead box H1 3.15095
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.1506
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.1431
PARP1 poly (ADP-ribose) polymerase 1 3.13105
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 3.08875
STXBP1 syntaxin binding protein 1 3.03145
CHMP6 charged multivesicular body protein 6 2.9969
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.98675
CRTAP cartilage associated protein 2.9853
ZBTB7B zinc finger and BTB domain containing 7B 2.96645
SERTAD3 SERTA domain containing 3 2.94605
AP1M2 adaptor-related protein complex 1, mu 2 subunit 2.90928
STAMBP STAM binding protein 2.9063
COL5A1 collagen, type V, alpha 1 2.88478
HLA-DMA major histocompatibility complex, class II, DM alpha 2.86775
MED9 mediator complex subunit 9 2.8497
SIRT1 sirtuin 1 2.8426
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.83865
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.83295
GATA3 GATA binding protein 3 2.8215
SH3BP1 SH3-domain binding protein 1 2.80315
GJC2 gap junction protein, gamma 2, 47kDa 2.79675
SERHL2 serine hydrolase-like 2 2.78677
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.7865
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.77338
IGFBP3 insulin-like growth factor binding protein 3 2.74995
RORC RAR-related orphan receptor C 2.7458
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.73935
HOOK2 hook microtubule-tethering protein 2 2.72538
PRRX2 paired related homeobox 2 2.7171
PIAS4 protein inhibitor of activated STAT, 4 2.7155
LRP10 low density lipoprotein receptor-related protein 10 2.7155
ERCC2 excision repair cross-complementation group 2 2.70615
MEPCE methylphosphate capping enzyme 2.7034
SPAG7 sperm associated antigen 7 2.70105
RBM38 RNA binding motif protein 38 2.69745
HBZ hemoglobin, zeta 2.67475
UFSP2 UFM1-specific peptidase 2 2.6704
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.66835
EML2 echinoderm microtubule associated protein like 2 2.6599
PUF60 poly-U binding splicing factor 60KDa 2.65855
RESF1 retroelement silencing factor 1 2.6567
LEFTY2 left-right determination factor 2 2.6553
HNRNPM heterogeneous nuclear ribonucleoprotein M 2.65135
NUP133 nucleoporin 133kDa 2.6503
RAX retina and anterior neural fold homeobox 2.6458
PRKCG protein kinase C, gamma 2.6429
SARAF store-operated calcium entry-associated regulatory factor 2.64135
RNF39 ring finger protein 39 2.63885
IGFLR1 IGF-like family receptor 1 2.62595
ZC4H2 zinc finger, C4H2 domain containing 2.61595
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 2.61545
MED22 mediator complex subunit 22 2.6142
PON3 paraoxonase 3 2.6138
ADM2 adrenomedullin 2 2.60485
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.60345
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 2.59995
ARSA arylsulfatase A 2.58905
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.5809
WDR62 WD repeat domain 62 2.5806
CNPY3 canopy FGF signaling regulator 3 2.5723
CCIN calicin 2.5711
RIC8A RIC8 guanine nucleotide exchange factor A 2.56455
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.5501
OSBP2 oxysterol binding protein 2 2.55
LIN28A lin-28 homolog A (C. elegans) 2.5479
GJA3 gap junction protein, alpha 3, 46kDa 2.54195
DKKL1 dickkopf-like 1 2.5367
CXCL3 chemokine (C-X-C motif) ligand 3 2.53085
SPTBN4 spectrin, beta, non-erythrocytic 4 2.5304
TRIM66 tripartite motif containing 66 2.5294
CLASRP CLK4-associating serine/arginine rich protein 2.52705
CHERP calcium homeostasis endoplasmic reticulum protein 2.51845
GPER1 G protein-coupled estrogen receptor 1 2.51558
OSGEP O-sialoglycoprotein endopeptidase 2.5097
BCL3 B-cell CLL/lymphoma 3 2.501
FLNB filamin B, beta 2.4966
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.49585
CD79B CD79b molecule, immunoglobulin-associated beta 2.4947
TRAM2 translocation associated membrane protein 2 2.49428
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 2.4716
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 2.46995
PRMT7 protein arginine methyltransferase 7 2.46165
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.4606
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 2.45785
DNM2 dynamin 2 2.4558
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.45315
DNM1L dynamin 1-like 2.44855
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 2.44815
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.44315
EDN2 endothelin 2 2.44245
EEIG1 estrogen-induced osteoclastogenesis regulator 1 2.4398
DEPTOR DEP domain containing MTOR-interacting protein 2.439
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.4354
SHBG sex hormone-binding globulin 2.4331
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.4295
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 2.42313
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.41688
NFE2L2 nuclear factor, erythroid 2-like 2 2.41392
PDCD1 programmed cell death 1 2.4096
KIF20A kinesin family member 20A 2.40945
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.39825
HDAC3 histone deacetylase 3 2.39745
VGLL4 vestigial-like family member 4 2.39223
PRSS16 protease, serine, 16 (thymus) 2.38835
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.38535
AQP6 aquaporin 6, kidney specific 2.38315
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.38255
EVL Enah/Vasp-like 2.3755
ZCWPW1 zinc finger, CW type with PWWP domain 1 2.3744
PRLH prolactin releasing hormone 2.36875
RALGDS ral guanine nucleotide dissociation stimulator 2.36142
ZNF84 zinc finger protein 84 2.3609
SLC66A3 solute carrier family 66 member 3 2.35965
EVX1 even-skipped homeobox 1 2.3592
FGFR3 fibroblast growth factor receptor 3 2.35668
EFNA4 ephrin-A4 2.3565
SEPHS1 selenophosphate synthetase 1 2.3483
MAEA macrophage erythroblast attacher 2.3481
POU5F1 POU class 5 homeobox 1 2.34729
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 2.34303
VAV1 vav 1 guanine nucleotide exchange factor 2.3297
MB myoglobin 2.3295
OVOL3 ovo-like zinc finger 3 2.3202
TCF3 transcription factor 3 2.31456
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.31315
CA8 carbonic anhydrase VIII 2.31275
BARX1 BARX homeobox 1 2.3118
SLC12A9 solute carrier family 12, member 9 2.31125
ALG6 ALG6, alpha-1,3-glucosyltransferase 2.3107
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.30505
CENPC centromere protein C 2.30395
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.3031
SLC22A17 solute carrier family 22, member 17 2.3004
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.29895
LAS1L LAS1-like (S. cerevisiae) 2.2948
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.29425
C2CD5 C2 calcium-dependent domain containing 5 2.29105
PAIP2B poly(A) binding protein interacting protein 2B 2.2882
ZNF180 zinc finger protein 180 2.28785
GUCA1B guanylate cyclase activator 1B (retina) 2.278
PCDHGA10 protocadherin gamma subfamily A, 10 2.2748
NEUROG3 neurogenin 3 2.2695
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.26935
VPREB1 pre-B lymphocyte 1 2.26845
EPHX3 epoxide hydrolase 3 2.2621
AMHR2 anti-Mullerian hormone receptor, type II 2.25805
DNASE1L2 deoxyribonuclease I-like 2 2.2556
CCKBR cholecystokinin B receptor 2.25085
DCHS2 dachsous cadherin-related 2 2.2456
SAMD4B sterile alpha motif domain containing 4B 2.24405
SIRT7 sirtuin 7 2.24335
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.2433
AATF apoptosis antagonizing transcription factor 2.2411
PFKL phosphofructokinase, liver 2.23888
TMEM223 transmembrane protein 223 2.2387
MATK megakaryocyte-associated tyrosine kinase 2.2373
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.23515
LDAF1 lipid droplet assembly factor 1 2.23245
MAPK7 mitogen-activated protein kinase 7 2.21845
NEUROD2 neuronal differentiation 2 2.2162
KCTD15 potassium channel tetramerization domain containing 15 2.2158
COLGALT1 collagen beta(1-O)galactosyltransferase 1 2.2144
UNC93B1 unc-93 homolog B1 (C. elegans) 2.20935
HOXB1 homeobox B1 2.20805
NAP1L3 nucleosome assembly protein 1-like 3 2.20725
NPY4R2 neuropeptide Y receptor Y4-2 2.2066
TNS4 tensin 4 2.20635
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.20525
OAZ3 ornithine decarboxylase antizyme 3 2.2048
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.2014
MYH9 myosin, heavy chain 9, non-muscle 2.19905
PARP16 poly (ADP-ribose) polymerase family, member 16 2.19735
TCL1A T-cell leukemia/lymphoma 1A 2.19675
SPTB spectrin, beta, erythrocytic 2.19275
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 2.19082
CBR4 carbonyl reductase 4 2.19065
INPPL1 inositol polyphosphate phosphatase-like 1 2.1842
TREX2 three prime repair exonuclease 2 2.1833
OVOL1 ovo-like zinc finger 1 2.1816
RHOH ras homolog family member H 2.1807
GHR growth hormone receptor 2.17795
CYCS cytochrome c, somatic 2.1738
RIGI RNA sensor RIG-I 2.173
FMNL1 formin-like 1 2.1693
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.1638
MARCKSL1 MARCKS-like 1 2.1586
PAX1 paired box 1 2.1559
CA12 carbonic anhydrase XII 2.14948
CENPE centromere protein E, 312kDa 2.14825
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 2.1482
SIRT3 sirtuin 3 2.13953
HPGDS hematopoietic prostaglandin D synthase 2.138
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 2.13678
DIAPH1 diaphanous-related formin 1 2.13248
GRAMD4 GRAM domain containing 4 2.1302
CD81 CD81 molecule 2.1278
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.12445
UCN urocortin 2.12305
SPI1 Spi-1 proto-oncogene 2.1215
ZFTA zinc finger translocation associated 2.11755
TENT4A terminal nucleotidyltransferase 4A 2.11595
OXT oxytocin/neurophysin I prepropeptide 2.1134
PPP4R3A protein phosphatase 4 regulatory subunit 3A 2.10925
BANK1 B-cell scaffold protein with ankyrin repeats 1 2.1072
RSU1 Ras suppressor protein 1 2.10705
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.1066
GCHFR GTP cyclohydrolase I feedback regulator 2.10295
CD19 CD19 molecule 2.1017
DCAF11 DDB1 and CUL4 associated factor 11 2.09857
PKP3 plakophilin 3 2.09792
GPR27 G protein-coupled receptor 27 2.09665
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.09605
ACSM3 acyl-CoA synthetase medium-chain family member 3 2.09262
FNBP1L formin binding protein 1-like 2.09125
TPSD1 tryptase delta 1 2.09035
GTPBP6 GTP binding protein 6 (putative) 2.09025
CRTC1 CREB regulated transcription coactivator 1 2.08878
N4BP3 NEDD4 binding protein 3 2.0886
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.0882
HAPLN2 hyaluronan and proteoglycan link protein 2 2.0854
TREH trehalase (brush-border membrane glycoprotein) 2.08475
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 2.0846
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.08281
ACTN3 actinin, alpha 3 (gene/pseudogene) 2.0817
SOCS1 suppressor of cytokine signaling 1 2.08087
USPL1 ubiquitin specific peptidase like 1 2.0743
CEP70 centrosomal protein 70kDa 2.0719
DAGLA diacylglycerol lipase, alpha 2.0693
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.0683
LHX5 LIM homeobox 5 2.0672
SSX5 synovial sarcoma, X breakpoint 5 2.0657
TET3 tet methylcytosine dioxygenase 3 2.0633
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.06122
CEND1 cell cycle exit and neuronal differentiation 1 2.05385
QPCTL glutaminyl-peptide cyclotransferase-like 2.0527
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.05153
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.04935
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.04725
GMIP GEM interacting protein 2.04555
CYFIP2 cytoplasmic FMR1 interacting protein 2 2.04507
CD34 CD34 molecule 2.0444
MMP11 matrix metallopeptidase 11 2.04433
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.04415
CTNNBIP1 catenin, beta interacting protein 1 2.04075
PLAAT4 phospholipase A and acyltransferase 4 2.03855
PLPP2 phospholipid phosphatase 2 2.03635
EZR ezrin 2.03385
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.03375
HIC2 hypermethylated in cancer 2 2.02714
RARG retinoic acid receptor, gamma 2.02575
KIF4A kinesin family member 4A 2.02405
DNAL4 dynein, axonemal, light chain 4 2.023
DIO3 deiodinase, iodothyronine, type III 2.0227
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 2.02028
SQOR sulfide quinone oxidoreductase 2.0168
POM121L2 POM121 transmembrane nucleoporin-like 2 2.01665
KLF13 Kruppel-like factor 13 2.0166
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2.01625
NPPC natriuretic peptide C 2.0159
ZNF428 zinc finger protein 428 2.0153
URM1 ubiquitin related modifier 1 2.01295
TGM5 transglutaminase 5 2.01285
BCL7A B-cell CLL/lymphoma 7A 2.01215
CRELD2 cysteine-rich with EGF-like domains 2 2.0116
TOLLIP toll interacting protein 2.0057
INSL4 insulin-like 4 (placenta) 2.00525
CLCN3 chloride channel, voltage-sensitive 3 2.00421
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.0028
SYN1 synapsin I 2.0013
MCUR1 mitochondrial calcium uniporter regulator 1 2.00005

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -7.45995
TLR4 toll-like receptor 4 -5.9304
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.6945
CCDC86 coiled-coil domain containing 86 -5.6648
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.43675
LOC124907782 dual specificity protein phosphatase 22 -5.2479
SNX11 sorting nexin 11 -4.9468
ALAS1 5'-aminolevulinate synthase 1 -4.87405
FBXL12 F-box and leucine-rich repeat protein 12 -4.8568
GTPBP8 GTP-binding protein 8 (putative) -4.8168
PECR peroxisomal trans-2-enoyl-CoA reductase -4.8037
COG7 component of oligomeric golgi complex 7 -4.66145
UGDH UDP-glucose 6-dehydrogenase -4.63905
HSPB1 heat shock 27kDa protein 1 -4.62385
ITGB1BP1 integrin beta 1 binding protein 1 -4.59917
TMEM50A transmembrane protein 50A -4.5774
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.46315
BLMH bleomycin hydrolase -4.3914
SNCA synuclein, alpha (non A4 component of amyloid precursor) -4.1241
ZW10 zw10 kinetochore protein -3.8973
CCNB1 cyclin B1 -3.70825
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.631
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.50155
ASCC3 activating signal cointegrator 1 complex subunit 3 -3.44085
HEATR1 HEAT repeat containing 1 -3.43805
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -3.394
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.35593
NR2F2 nuclear receptor subfamily 2, group F, member 2 -3.27007
MAPK13 mitogen-activated protein kinase 13 -3.2507
SLC12A8 solute carrier family 12, member 8 -3.23145
GSTM2 glutathione S-transferase mu 2 (muscle) -3.22652
CRYZ crystallin, zeta (quinone reductase) -3.1835
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -3.1672
STX4 syntaxin 4 -3.1528
PRKCD protein kinase C, delta -3.1517
C5 complement component 5 -3.1051
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.09495
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -3.0855
CCDC181 coiled-coil domain containing 181 -3.0769
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -3.0755
LYRM4 LYR motif containing 4 -3.06745
GNAS GNAS complex locus -3.04994
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.9917
CTSH cathepsin H -2.97895
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.9634
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -2.9528
RTF2 replication termination factor 2 -2.93995
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.93525
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.9019
FHL2 four and a half LIM domains 2 -2.8841
JUN jun proto-oncogene -2.88345
ZC3H7A zinc finger CCCH-type containing 7A -2.8574
MRPS31 mitochondrial ribosomal protein S31 -2.8554
NGRN neugrin, neurite outgrowth associated -2.85245
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.84285
WASHC5 WASH complex subunit 5 -2.81895
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.8034
ORC6 origin recognition complex, subunit 6 -2.79955
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.79665
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.7957
FGL1 fibrinogen-like 1 -2.7862
CHEK1 checkpoint kinase 1 -2.7818
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -2.77903
LHFPL6 LHFPL tetraspan subfamily member 6 -2.77465
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 -2.7467
FCHSD2 FCH and double SH3 domains 2 -2.74465
THOC7 THO complex 7 -2.74105
HYOU1 hypoxia up-regulated 1 -2.7269
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.7236
ZDHHC6 zinc finger, DHHC-type containing 6 -2.72225
TWF2 twinfilin actin binding protein 2 -2.7148
CCP110 centriolar coiled coil protein 110kDa -2.70485
TMEM214 transmembrane protein 214 -2.6931
GLT8D1 glycosyltransferase 8 domain containing 1 -2.65852
TOMM34 translocase of outer mitochondrial membrane 34 -2.62055
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.62
NISCH nischarin -2.6164
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -2.61595
TMEM258 transmembrane protein 258 -2.6069
METTL25B methyltransferase like 25B -2.5873
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -2.57942
ZFYVE26 zinc finger, FYVE domain containing 26 -2.56615
MRPL33 mitochondrial ribosomal protein L33 -2.553
RUSF1 RUS family member 1 -2.53478
APOC1 apolipoprotein C-I -2.52535
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -2.52297
E2F6 E2F transcription factor 6 -2.51895
SCCPDH saccharopine dehydrogenase (putative) -2.51455
BCAT1 branched chain amino-acid transaminase 1, cytosolic -2.51192
ZNF512B zinc finger protein 512B -2.5072
KATNIP katanin interacting protein -2.496
TIPRL TOR signaling pathway regulator -2.4956
TRAPPC12 trafficking protein particle complex 12 -2.49435
NCKAP1 NCK-associated protein 1 -2.485
DEXI Dexi homolog (mouse) -2.48275
GPC1 glypican 1 -2.4797
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -2.47405
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.4737
RAI14 retinoic acid induced 14 -2.46705
DCAF6 DDB1 and CUL4 associated factor 6 -2.46165
PARG poly (ADP-ribose) glycohydrolase -2.45235
RING1 ring finger protein 1 -2.44485
SMC3 structural maintenance of chromosomes 3 -2.44253
LCMT1 leucine carboxyl methyltransferase 1 -2.4418
PIGF phosphatidylinositol glycan anchor biosynthesis, class F -2.42815
BCL2A1 BCL2-related protein A1 -2.4165
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -2.41065
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -2.4047
VGLL3 vestigial-like family member 3 -2.4035
PTOV1 prostate tumor overexpressed 1 -2.39625
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -2.39143
EED embryonic ectoderm development -2.38963
EXD2 exonuclease 3'-5' domain containing 2 -2.38955
RNF2 ring finger protein 2 -2.38765
GRN granulin -2.37542
DVL3 dishevelled segment polarity protein 3 -2.36715
RAD51AP1 RAD51 associated protein 1 -2.34395
PCID2 PCI domain containing 2 -2.34355
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.3415
HEG1 heart development protein with EGF-like domains 1 -2.3407
NHLRC2 NHL repeat containing 2 -2.3359
COPG1 coatomer protein complex, subunit gamma 1 -2.33415
TRIB1 tribbles pseudokinase 1 -2.3314
POLK polymerase (DNA directed) kappa -2.32165
MOXD1 monooxygenase, DBH-like 1 -2.31685
VMP1 vacuole membrane protein 1 -2.3167
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.30965
APCS amyloid P component, serum -2.3092
TMEM115 transmembrane protein 115 -2.3003
APOE apolipoprotein E -2.29867
INTS9 integrator complex subunit 9 -2.2926
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.29015
TMEM184C transmembrane protein 184C -2.28025
PARK7 parkinson protein 7 -2.2753
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.27305
NABP2 nucleic acid binding protein 2 -2.26735
XPO6 exportin 6 -2.2648
FKBP1A FK506 binding protein 1A, 12kDa -2.26097
PHKB phosphorylase kinase, beta -2.25865
NPIPB5 nuclear pore complex interacting protein family, member B5 -2.2503
NFE2L1 nuclear factor, erythroid 2-like 1 -2.24857
PTPRU protein tyrosine phosphatase, receptor type, U -2.23653
MYL12B myosin, light chain 12B, regulatory -2.23365
CENPT centromere protein T -2.2332
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -2.22925
LZTR1 leucine-zipper-like transcription regulator 1 -2.2268
MRPL48 mitochondrial ribosomal protein L48 -2.2252
TP53BP1 tumor protein p53 binding protein 1 -2.21925
CAPZB capping protein (actin filament) muscle Z-line, beta -2.21627
TRAP1 TNF receptor-associated protein 1 -2.2146
FLOT1 flotillin 1 -2.21047
TCTN1 tectonic family member 1 -2.2098
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus -2.20895
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 -2.2082
SPATS2 spermatogenesis associated, serine-rich 2 -2.20725
TRMT61B tRNA methyltransferase 61B -2.20295
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.20255
PSG2 pregnancy specific beta-1-glycoprotein 2 -2.1945
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit -2.19235
JAG1 jagged 1 -2.19108
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -2.184
NIT2 nitrilase family, member 2 -2.1797
VKORC1 vitamin K epoxide reductase complex, subunit 1 -2.17775
NKRF NFKB repressing factor -2.17645
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.1712
PIPOX pipecolic acid oxidase -2.16405
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -2.1589
HSPA1B heat shock 70kDa protein 1B -2.14967
TMEM230 transmembrane protein 230 -2.1445
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.1389
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 -2.13835
WASF3 WAS protein family, member 3 -2.13705
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 -2.13625
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -2.123
NBEAL2 neurobeachin-like 2 -2.12295
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.12055
IER5 immediate early response 5 -2.12035
ACADVL acyl-CoA dehydrogenase, very long chain -2.11825
CCDC59 coiled-coil domain containing 59 -2.106
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -2.10425
GTF2IRD1 GTF2I repeat domain containing 1 -2.0997
DEK DEK proto-oncogene -2.0978
FAM131B family with sequence similarity 131, member B -2.09525
AMOTL2 angiomotin like 2 -2.0949
CTSG cathepsin G -2.09275
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -2.09045
MTA1 metastasis associated 1 -2.0864
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.0806
ADRB2 adrenoceptor beta 2, surface -2.07605
TTK TTK protein kinase -2.0744
CDO1 cysteine dioxygenase type 1 -2.0699
ATRN attractin -2.06218
TMEM222 transmembrane protein 222 -2.0595
KIF1A kinesin family member 1A -2.058
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.05645
ESD esterase D -2.05575
ACOT9 acyl-CoA thioesterase 9 -2.05495
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -2.05245
SCML1 sex comb on midleg-like 1 (Drosophila) -2.0519
ARHGAP17 Rho GTPase activating protein 17 -2.0454
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.04245
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -2.03145
KAT8 K(lysine) acetyltransferase 8 -2.02898
S100A4 S100 calcium binding protein A4 -2.0247
GPX3 glutathione peroxidase 3 -2.02422
MKRN2 makorin ring finger protein 2 -2.0218
SAP30 Sin3A-associated protein, 30kDa -2.01855
HEATR3 HEAT repeat containing 3 -2.01175
ELOC elongin C -2.0112
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C -2.01105
ELMO2 engulfment and cell motility 2 -2.01027
CD58 CD58 molecule -2.01017
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) -2.0057
ATP7B ATPase, Cu++ transporting, beta polypeptide -2.0046
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.0044
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -2.00255
IRF3 interferon regulatory factor 3 -2.0011