CRCGN014_HEPG2_24H:K04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hc yellow 4 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN014_HEPG2_24H:K04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.21006
ANO1 anoctamin 1, calcium activated chloride channel 4.19648
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.89716
RPP38 ribonuclease P/MRP 38kDa subunit 3.87884
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.75986
CHMP6 charged multivesicular body protein 6 3.26947
GATA3 GATA binding protein 3 2.99385
PPARG peroxisome proliferator-activated receptor gamma 2.94812
C2CD2 C2 calcium-dependent domain containing 2 2.7654
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.75442
CIAO3 cytosolic iron-sulfur assembly component 3 2.67198
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.57885
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.57129
THAP12 THAP domain containing 12 2.48259
CEP57 centrosomal protein 57kDa 2.31336
PEX11A peroxisomal biogenesis factor 11 alpha 2.3031
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.20298
ATP11B ATPase, class VI, type 11B 2.20185
GSTZ1 glutathione S-transferase zeta 1 2.11852
UBL5 ubiquitin-like 5 2.0463
MAP7 microtubule-associated protein 7 2.02472

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -7.19319
LDHD lactate dehydrogenase D -6.8917
CCNB2 cyclin B2 -4.71766
TLR4 toll-like receptor 4 -4.42726
UGDH UDP-glucose 6-dehydrogenase -4.38915
VAT1 vesicle amine transport 1 -4.08549
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.97503
NGRN neugrin, neurite outgrowth associated -3.51908
TUBB6 tubulin, beta 6 class V -3.14453
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.05126
OXA1L oxidase (cytochrome c) assembly 1-like -2.92985
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.91485
PPOX protoporphyrinogen oxidase -2.80307
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.57374
DNM1L dynamin 1-like -2.57334
UBE3C ubiquitin protein ligase E3C -2.41257
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.245
AZU1 azurocidin 1 -2.24007
RAI14 retinoic acid induced 14 -2.07047