CRCGN014_HEPG2_24H:K08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-thiodianiline 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN014_HEPG2_24H:K08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 10.0
STIMATE STIM activating enhancer 3.65846
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.65684
CHMP6 charged multivesicular body protein 6 3.60311
MSRA methionine sulfoxide reductase A 3.54006
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.52972
ATP11B ATPase, class VI, type 11B 3.28695
HOXA10 homeobox A10 3.25588
CCDC85B coiled-coil domain containing 85B 3.22925
LCN2 lipocalin 2 3.12828
CRTAP cartilage associated protein 3.1063
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.08149
JADE2 jade family PHD finger 2 2.9383
ADAM10 ADAM metallopeptidase domain 10 2.40765
GPER1 G protein-coupled estrogen receptor 1 2.39118
CXCL2 chemokine (C-X-C motif) ligand 2 2.21199
SFTPB surfactant protein B 2.01979

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -6.62597
LDHD lactate dehydrogenase D -3.67672
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.65672
VAT1 vesicle amine transport 1 -3.57806
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.54647
ISOC1 isochorismatase domain containing 1 -3.53973
ANKRD10 ankyrin repeat domain 10 -3.42658
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.40281
PCNA proliferating cell nuclear antigen -3.34586
TLCD3A TLC domain containing 3A -3.20316
EGF epidermal growth factor -3.07433
ZNF586 zinc finger protein 586 -2.67502
SNX11 sorting nexin 11 -2.60793
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.36733
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.24665