CRCGN014_HEPG2_24H:K12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitro-o-phenylenediamine 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN014_HEPG2_24H:K12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.58724
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.9006
CYCS cytochrome c, somatic 4.84113
TXNRD1 thioredoxin reductase 1 4.50676
ABHD4 abhydrolase domain containing 4 4.22704
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 4.12663
C2CD2 C2 calcium-dependent domain containing 2 4.03863
MYLK myosin light chain kinase 3.45165
NOTCH1 notch 1 3.32627
CIAO3 cytosolic iron-sulfur assembly component 3 3.20588
UBQLN2 ubiquilin 2 3.19531
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.14438
EPHA3 EPH receptor A3 3.10494
HMOX1 heme oxygenase 1 3.02525
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.92795
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.87493
PPARG peroxisome proliferator-activated receptor gamma 2.83498
HLA-DRA major histocompatibility complex, class II, DR alpha 2.80526
SYNE2 spectrin repeat containing, nuclear envelope 2 2.75875
LCN2 lipocalin 2 2.75288
STIMATE STIM activating enhancer 2.7162
NOSIP nitric oxide synthase interacting protein 2.58234
CCNA1 cyclin A1 2.48356
KEAP1 kelch-like ECH-associated protein 1 2.39678
CCP110 centriolar coiled coil protein 110kDa 2.36276
CTSL cathepsin L 2.34817
MAST2 microtubule associated serine/threonine kinase 2 2.34074
CBR1 carbonyl reductase 1 2.31336
PLS1 plastin 1 2.2699
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.24469
SQSTM1 sequestosome 1 2.174
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.15625
ATP11B ATPase, class VI, type 11B 2.14423
CDPF1 cysteine-rich, DPF motif domain containing 1 2.11595
GNPDA1 glucosamine-6-phosphate deaminase 1 2.05082
TKT transketolase 2.04201

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.16633
NT5DC2 5'-nucleotidase domain containing 2 -3.6196
PCNA proliferating cell nuclear antigen -3.41318
KDM3A lysine (K)-specific demethylase 3A -3.28823
CHMP4B charged multivesicular body protein 4B -3.04228
CCNB2 cyclin B2 -2.91376
SLC35F2 solute carrier family 35, member F2 -2.84399
VAT1 vesicle amine transport 1 -2.74456
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.71019
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.65705
TLCD3A TLC domain containing 3A -2.64046
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.61845
ZNF586 zinc finger protein 586 -2.56042
FASTKD5 FAST kinase domains 5 -2.45812
EGF epidermal growth factor -2.44025
ZW10 zw10 kinetochore protein -2.35476
SOAT2 sterol O-acyltransferase 2 -2.34988
HOXA5 homeobox A5 -2.12275
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.11662
HYOU1 hypoxia up-regulated 1 -2.06498
PSRC1 proline/serine-rich coiled-coil 1 -2.06492
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.02096