CRCGN014_HEPG2_24H:K14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-chloroaniline 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN014_HEPG2_24H:K14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 6.39197
EVL Enah/Vasp-like 4.46778
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.05946
LOC122526780 uncharacterized LOC122526780 3.95734
DDIT4 DNA-damage-inducible transcript 4 3.68702
ABHD6 abhydrolase domain containing 6 3.39671
CIAO3 cytosolic iron-sulfur assembly component 3 3.26194
ATP11B ATPase, class VI, type 11B 3.22328
INTS3 integrator complex subunit 3 3.16695
LCN2 lipocalin 2 3.09862
SFTPB surfactant protein B 2.99032
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.89437
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.83011
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.80803
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.75939
CXCR4 chemokine (C-X-C motif) receptor 4 2.66236
RXYLT1 ribitol xylosyltransferase 1 2.61807
NMU neuromedin U 2.53534
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.48229
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.44763
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.4238
PLS1 plastin 1 2.37808
CXCL2 chemokine (C-X-C motif) ligand 2 2.32771
KLHDC2 kelch domain containing 2 2.3241
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.30354
NUCB2 nucleobindin 2 2.28028
DIPK1A divergent protein kinase domain 1A 2.27448
ABHD4 abhydrolase domain containing 4 2.15073
FAIM Fas apoptotic inhibitory molecule 2.14199
SNX7 sorting nexin 7 2.10097

decreased expression

Symbol Name Standardized Value
PLK1 polo-like kinase 1 -4.35389
DNM1L dynamin 1-like -4.29853
ZNF586 zinc finger protein 586 -4.12521
NT5DC2 5'-nucleotidase domain containing 2 -3.76665
PCNA proliferating cell nuclear antigen -3.65729
NGRN neugrin, neurite outgrowth associated -3.49336
VAT1 vesicle amine transport 1 -3.42301
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.27396
MRPS2 mitochondrial ribosomal protein S2 -3.18847
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.84487
LDHD lactate dehydrogenase D -2.70157
FGFR4 fibroblast growth factor receptor 4 -2.69222
SLC35F2 solute carrier family 35, member F2 -2.66792
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.1595
LRRC41 leucine rich repeat containing 41 -2.09402
OXA1L oxidase (cytochrome c) assembly 1-like -2.09059
TCF21 transcription factor 21 -2.04926
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -2.0307