CRCGN014_HEPG2_24H:K15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description succinic anhydride 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN014_HEPG2_24H:K15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 3.87694
NOTCH1 notch 1 3.81927
MCOLN1 mucolipin 1 3.73876
BZW2 basic leucine zipper and W2 domains 2 3.51203
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.43425
CCNF cyclin F 3.27536
CCNA1 cyclin A1 3.26586
CYCS cytochrome c, somatic 2.95776
CHMP6 charged multivesicular body protein 6 2.93277
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.9216
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.8687
MAP7 microtubule-associated protein 7 2.83687
PFKL phosphofructokinase, liver 2.71417
AMDHD2 amidohydrolase domain containing 2 2.63165
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.48101
EPHA3 EPH receptor A3 2.40423
KIF5C kinesin family member 5C 2.33557
CORO1A coronin, actin binding protein, 1A 2.02253

decreased expression

Symbol Name Standardized Value
C2CD5 C2 calcium-dependent domain containing 5 -6.71765
ZNF586 zinc finger protein 586 -5.96765
VAT1 vesicle amine transport 1 -3.91321
LAP3 leucine aminopeptidase 3 -3.62124
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.5447
FASTKD5 FAST kinase domains 5 -3.49704
CDC20 cell division cycle 20 -3.45554
TLR4 toll-like receptor 4 -3.41785
TM9SF3 transmembrane 9 superfamily member 3 -3.38974
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.36638
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.29202
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.19171
TUBB6 tubulin, beta 6 class V -3.17599
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.16328
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.13994
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.84604
MRPS2 mitochondrial ribosomal protein S2 -2.82181
PCNA proliferating cell nuclear antigen -2.80395
LDHD lactate dehydrogenase D -2.69337
SLC35F2 solute carrier family 35, member F2 -2.54134
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.46509
ETNK1 ethanolamine kinase 1 -2.43168
OXA1L oxidase (cytochrome c) assembly 1-like -2.42245
MAPK13 mitogen-activated protein kinase 13 -2.41761
GNAS GNAS complex locus -2.39681
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.22809
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) -2.20927
SNAP91 synaptosomal-associated protein, 91kDa -2.08432
SPAG4 sperm associated antigen 4 -2.06769
USP9X ubiquitin specific peptidase 9, X-linked -2.0506