CRCGN014_HEPG2_24H:K17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[(4-oxo-1,2,3-benzotriazin-3(4h)-yl)methyl] dithiophosphate 21.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN014_HEPG2_24H:K17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 8.16614
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.67236
CXCL2 chemokine (C-X-C motif) ligand 2 5.63621
CARMIL1 capping protein regulator and myosin 1 linker 1 5.08144
PNKP polynucleotide kinase 3'-phosphatase 4.78329
CHN1 chimerin 1 4.23347
ANO1 anoctamin 1, calcium activated chloride channel 3.64178
PPARG peroxisome proliferator-activated receptor gamma 3.03645
DIPK1A divergent protein kinase domain 1A 2.98748
MAP7 microtubule-associated protein 7 2.8697
GSTZ1 glutathione S-transferase zeta 1 2.78449
PRKCH protein kinase C, eta 2.78372
LUM lumican 2.63278
ZNF589 zinc finger protein 589 2.59309
FAM50A family with sequence similarity 50, member A 2.51108
BIRC2 baculoviral IAP repeat containing 2 2.39755
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.26689
SRPX sushi-repeat containing protein, X-linked 2.2468
CHEK2 checkpoint kinase 2 2.18242
CNPY3 canopy FGF signaling regulator 3 2.16473

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -7.52387
ZNF586 zinc finger protein 586 -6.36792
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.6822
CDC20 cell division cycle 20 -4.94305
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.91197
CCNB2 cyclin B2 -4.53209
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.69319
ADI1 acireductone dioxygenase 1 -3.48849
NRIP1 nuclear receptor interacting protein 1 -2.49431
TCTN1 tectonic family member 1 -2.1781
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.16306
KLHDC2 kelch domain containing 2 -2.11703
NLRX1 NLR family member X1 -2.00719