CRCGN014_HEPG2_24H:K21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[2-(methylamino)-2-oxoethyl] dithiophosphate 20.62 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN014_HEPG2_24H:K21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 7.71343
PPARG peroxisome proliferator-activated receptor gamma 6.20911
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.04802
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.89835
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.7294
CXCL2 chemokine (C-X-C motif) ligand 2 2.8216
LPAR2 lysophosphatidic acid receptor 2 2.45355
BPHL biphenyl hydrolase-like (serine hydrolase) 2.40594
PLS1 plastin 1 2.36937
UBQLN2 ubiquilin 2 2.29626
CIAO3 cytosolic iron-sulfur assembly component 3 2.25802
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.12101

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.10526
ZNF586 zinc finger protein 586 -4.06644
TM9SF3 transmembrane 9 superfamily member 3 -4.03097
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.308
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.87164
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.75763
CDC20 cell division cycle 20 -2.71279
LAP3 leucine aminopeptidase 3 -2.38327
RPS5 ribosomal protein S5 -2.32272
FBXL12 F-box and leucine-rich repeat protein 12 -2.30032
GNAS GNAS complex locus -2.06871
VDAC1 voltage-dependent anion channel 1 -2.02983