CRCGN014_HEPG2_24H:K22 Gene Set
Genes
35 genes differentially expressed following the CRCGN014_HEPG2_24H:K22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
PRKCH
|
protein kinase C, eta
|
5.21718
|
|
HERC6
|
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
|
4.93412
|
|
LCN2
|
lipocalin 2
|
4.91144
|
|
BACE2
|
beta-site APP-cleaving enzyme 2
|
3.39587
|
|
ABCC5
|
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
|
2.67715
|
|
CIAO3
|
cytosolic iron-sulfur assembly component 3
|
2.57049
|
|
TCEAL4
|
transcription elongation factor A (SII)-like 4
|
2.55677
|
|
UBQLN2
|
ubiquilin 2
|
2.45424
|
|
NOTCH1
|
notch 1
|
2.35965
|
|
CTSL
|
cathepsin L
|
2.2806
|
|
HSPB1
|
heat shock 27kDa protein 1
|
2.21796
|
|
POLR2I
|
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
|
2.19401
|
|
SMARCD2
|
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
|
2.18921
|
|
MYLK
|
myosin light chain kinase
|
2.12993
|
|
GPATCH8
|
G patch domain containing 8
|
2.11158
|
|
NUDT9
|
nudix (nucleoside diphosphate linked moiety X)-type motif 9
|
2.00304
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
ADI1
|
acireductone dioxygenase 1
|
-4.93441
|
|
TLR4
|
toll-like receptor 4
|
-3.98158
|
|
TARBP1
|
TAR (HIV-1) RNA binding protein 1
|
-3.39476
|
|
IARS2
|
isoleucyl-tRNA synthetase 2, mitochondrial
|
-3.27396
|
|
BMP4
|
bone morphogenetic protein 4
|
-3.25219
|
|
DUSP11
|
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
|
-3.19792
|
|
CDKN1B
|
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
|
-3.11359
|
|
SLC7A5
|
solute carrier family 7 (amino acid transporter light chain, L system), member 5
|
-2.90629
|
|
GNAS
|
GNAS complex locus
|
-2.68081
|
|
DERA
|
deoxyribose-phosphate aldolase (putative)
|
-2.66613
|
|
PCCB
|
propionyl CoA carboxylase, beta polypeptide
|
-2.56713
|
|
HSD17B11
|
hydroxysteroid (17-beta) dehydrogenase 11
|
-2.30321
|
|
CCNB2
|
cyclin B2
|
-2.2846
|
|
LDHD
|
lactate dehydrogenase D
|
-2.27606
|
|
MAPK13
|
mitogen-activated protein kinase 13
|
-2.27187
|
|
CHEK1
|
checkpoint kinase 1
|
-2.20731
|
|
ZMIZ1
|
zinc finger, MIZ-type containing 1
|
-2.1822
|
|
HMGCS1
|
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
|
-2.16041
|
|
RAI14
|
retinoic acid induced 14
|
-2.12424
|
