CRCGN014_HEPG2_24H:L01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloroacetophenone 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

175 genes differentially expressed following the CRCGN014_HEPG2_24H:L01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 7.09774
PLS1 plastin 1 7.05036
JADE2 jade family PHD finger 2 5.65312
CHN1 chimerin 1 5.4974
KCNK1 potassium channel, two pore domain subfamily K, member 1 5.4101
TRAK2 trafficking protein, kinesin binding 2 4.98414
NANOS3 nanos homolog 3 (Drosophila) 4.90306
E2F2 E2F transcription factor 2 4.8486
CCDC92 coiled-coil domain containing 92 4.79325
EPN2 epsin 2 4.6234
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.57209
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.44367
MAP7 microtubule-associated protein 7 4.43497
CXCL2 chemokine (C-X-C motif) ligand 2 4.42232
LCN2 lipocalin 2 4.3907
CCL2 chemokine (C-C motif) ligand 2 4.25788
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.14182
NOTCH1 notch 1 4.04704
EAPP E2F-associated phosphoprotein 3.95388
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.91217
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.89265
EPHB2 EPH receptor B2 3.61981
CYCS cytochrome c, somatic 3.25831
FZD7 frizzled class receptor 7 3.10344
ADGRE5 adhesion G protein-coupled receptor E5 2.96542
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.94898
GSTZ1 glutathione S-transferase zeta 1 2.94004
PPARG peroxisome proliferator-activated receptor gamma 2.89728
CCNF cyclin F 2.85875
SFTPB surfactant protein B 2.79316
CFAP44 cilia and flagella associated protein 44 2.72814
YTHDC1 YTH domain containing 1 2.69374
SERTAD3 SERTA domain containing 3 2.65953
CARMIL1 capping protein regulator and myosin 1 linker 1 2.65429
BAD BCL2-associated agonist of cell death 2.65311
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.58373
PDCD1 programmed cell death 1 2.562
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.54376
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.5213
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.48389
QSER1 glutamine and serine rich 1 2.44835
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.42216
NYNRIN NYN domain and retroviral integrase containing 2.41892
CRNN cornulin 2.40943
LYN LYN proto-oncogene, Src family tyrosine kinase 2.39132
EPHA3 EPH receptor A3 2.3855
AMDHD2 amidohydrolase domain containing 2 2.37506
PCDHB1 protocadherin beta 1 2.36528
BCCIP BRCA2 and CDKN1A interacting protein 2.34851
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.3433
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.33556
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.33003
GAGE1 G antigen 1 2.29808
ATAD3A ATPase family, AAA domain containing 3A 2.29683
ACBD4 acyl-CoA binding domain containing 4 2.29417
DEFB126 defensin, beta 126 2.29095
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.28812
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.28767
CDC45 cell division cycle 45 2.28761
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.28508
TCF21 transcription factor 21 2.27087
KIF18B kinesin family member 18B 2.26843
OVOL3 ovo-like zinc finger 3 2.26788
CDX4 caudal type homeobox 4 2.2666
RAB15 RAB15, member RAS oncogene family 2.26455
CT55 cancer/testis antigen 55 2.26004
FOXF1 forkhead box F1 2.25878
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.25802
FAT4 FAT atypical cadherin 4 2.24698
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like 2.23468
ECHDC2 enoyl CoA hydratase domain containing 2 2.23188
KIF26B kinesin family member 26B 2.23132
PRKCG protein kinase C, gamma 2.23102
CER1 cerberus 1, DAN family BMP antagonist 2.21601
MAP3K20 mitogen-activated protein kinase kinase kinase 20 2.21537
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.20727
DIO3 deiodinase, iodothyronine, type III 2.18631
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 2.18554
COL14A1 collagen, type XIV, alpha 1 2.1827
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.16674
TPSD1 tryptase delta 1 2.1518
HLA-DRA major histocompatibility complex, class II, DR alpha 2.14998
HIC1 hypermethylated in cancer 1 2.14605
ATP7A ATPase, Cu++ transporting, alpha polypeptide 2.1404
CNKSR1 connector enhancer of kinase suppressor of Ras 1 2.13988
PCDHGA11 protocadherin gamma subfamily A, 11 2.13491
EMD emerin 2.13436
PRDM8 PR domain containing 8 2.12181
ZBTB7B zinc finger and BTB domain containing 7B 2.12051
STAP2 signal transducing adaptor family member 2 2.11822
CELA2B chymotrypsin-like elastase family, member 2B 2.11605
C2CD2 C2 calcium-dependent domain containing 2 2.11302
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 2.11206
PCDHGA3 protocadherin gamma subfamily A, 3 2.10702
ALCAM activated leukocyte cell adhesion molecule 2.10292
SAGE1 sarcoma antigen 1 2.08921
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.0876
CCDC82 coiled-coil domain containing 82 2.07572
GPR39 G protein-coupled receptor 39 2.06884
PDZRN4 PDZ domain containing ring finger 4 2.06585
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.06372
H4C7 H4 clustered histone 7 2.06243
FSCN2 fascin actin-bundling protein 2, retinal 2.05976
DOCK1 dedicator of cytokinesis 1 2.05704
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.05379
TBX4 T-box 4 2.04559
TRIP10 thyroid hormone receptor interactor 10 2.03977
ANKRD17 ankyrin repeat domain 17 2.03317
LHX5 LIM homeobox 5 2.03231
FOXB1 forkhead box B1 2.03104
SELENBP1 selenium binding protein 1 2.02719
GRAMD4 GRAM domain containing 4 2.02032
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.01796
RPGRIP1L RPGRIP1-like 2.0076
TMEM267 transmembrane protein 267 2.00427
GRB10 growth factor receptor-bound protein 10 2.0034
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.00201
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.00047

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -7.19962
CCDC86 coiled-coil domain containing 86 -7.08715
KDM3A lysine (K)-specific demethylase 3A -6.98199
LDHD lactate dehydrogenase D -6.85676
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.3603
TLCD3A TLC domain containing 3A -5.59913
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -5.34336
FAIM Fas apoptotic inhibitory molecule -5.09402
ADI1 acireductone dioxygenase 1 -4.55744
PCNA proliferating cell nuclear antigen -4.45187
CCNB2 cyclin B2 -4.37977
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.33344
UGDH UDP-glucose 6-dehydrogenase -4.21864
TMEM109 transmembrane protein 109 -3.90222
DSG2 desmoglein 2 -3.82888
COG7 component of oligomeric golgi complex 7 -3.56398
ZW10 zw10 kinetochore protein -3.53514
ITGB1BP1 integrin beta 1 binding protein 1 -3.3146
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.30236
RAI14 retinoic acid induced 14 -3.3007
MAPK13 mitogen-activated protein kinase 13 -3.23252
LYPLA1 lysophospholipase I -3.17933
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.16033
RGS2 regulator of G-protein signaling 2 -3.04491
GOLT1B golgi transport 1B -2.9545
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.94588
MRPS2 mitochondrial ribosomal protein S2 -2.89994
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.88629
RFC2 replication factor C (activator 1) 2, 40kDa -2.82995
TOMM34 translocase of outer mitochondrial membrane 34 -2.80163
FOS FBJ murine osteosarcoma viral oncogene homolog -2.78758
HMG20B high mobility group 20B -2.77203
MYCBP MYC binding protein -2.63041
GNAS GNAS complex locus -2.62867
MRPS15 mitochondrial ribosomal protein S15 -2.54444
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.51342
LRRC41 leucine rich repeat containing 41 -2.49848
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -2.38616
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.30741
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.29552
DDIT4 DNA-damage-inducible transcript 4 -2.29028
TAGLN3 transgelin 3 -2.26186
PIGP phosphatidylinositol glycan anchor biosynthesis, class P -2.25017
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.24876
KRT2 keratin 2, type II -2.24623
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.2336
DNM1L dynamin 1-like -2.20059
LYRM2 LYR motif containing 2 -2.17237
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.16085
RRAGC Ras-related GTP binding C -2.11604
VAT1 vesicle amine transport 1 -2.11542
PTCD3 pentatricopeptide repeat domain 3 -2.11517
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.11396
ZDHHC6 zinc finger, DHHC-type containing 6 -2.06507
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.04439
NCAPG2 non-SMC condensin II complex, subunit G2 -2.03125
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.02276