CRCGN014_HEPG2_24H:L02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diphenhydramine 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN014_HEPG2_24H:L02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
LCN2 lipocalin 2 3.85445
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.68991
EVL Enah/Vasp-like 3.64669
STIMATE STIM activating enhancer 3.35941
UBQLN2 ubiquilin 2 3.35902
CARMIL1 capping protein regulator and myosin 1 linker 1 3.2386
DYNLT3 dynein, light chain, Tctex-type 3 3.16316
CHN1 chimerin 1 3.09011
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 3.07275
CDC45 cell division cycle 45 2.86511
ADRB2 adrenoceptor beta 2, surface 2.76093
RXYLT1 ribitol xylosyltransferase 1 2.65152
CXCL2 chemokine (C-X-C motif) ligand 2 2.4119
BTN3A1 butyrophilin, subfamily 3, member A1 2.33024
ANO1 anoctamin 1, calcium activated chloride channel 2.29952
LPAR2 lysophosphatidic acid receptor 2 2.256
GPATCH8 G patch domain containing 8 2.22469
RPP38 ribonuclease P/MRP 38kDa subunit 2.16396
GATA3 GATA binding protein 3 2.14787
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.14099
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.01087

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -5.87383
PCNA proliferating cell nuclear antigen -5.71538
FASTKD5 FAST kinase domains 5 -5.4396
TLCD3A TLC domain containing 3A -5.27729
MRPS2 mitochondrial ribosomal protein S2 -4.36026
TLR4 toll-like receptor 4 -4.20257
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.08459
MAPK13 mitogen-activated protein kinase 13 -4.0682
SCAND1 SCAN domain containing 1 -4.03904
ZNF586 zinc finger protein 586 -3.49649
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.35235
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.0263
LAP3 leucine aminopeptidase 3 -3.0153
UGDH UDP-glucose 6-dehydrogenase -2.85182
PECR peroxisomal trans-2-enoyl-CoA reductase -2.78988
DNM1L dynamin 1-like -2.72168
CCL27 chemokine (C-C motif) ligand 27 -2.70612
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.7054
CCNB2 cyclin B2 -2.57052
WASHC4 WASH complex subunit 4 -2.47266
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.43912
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.41289
C2CD5 C2 calcium-dependent domain containing 5 -2.40588
LORICRIN loricrin cornified envelope precursor protein -2.40185
FLG filaggrin -2.32551
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.24042
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D -2.1619
CDHR1 cadherin-related family member 1 -2.15126
ADI1 acireductone dioxygenase 1 -2.14317
ZBTB16 zinc finger and BTB domain containing 16 -2.13342
LCE2B late cornified envelope 2B -2.11004
RAI14 retinoic acid induced 14 -2.08934
TACC2 transforming, acidic coiled-coil containing protein 2 -2.04777
DSG1 desmoglein 1 -2.03968
DENND5B DENN/MADD domain containing 5B -2.03843