CRCGN014_HEPG2_24H:L06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN014_HEPG2_24H:L06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 4.88514
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.46108
BPHL biphenyl hydrolase-like (serine hydrolase) 4.02369
EPHA3 EPH receptor A3 3.42561
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.27596
LAGE3 L antigen family, member 3 3.12318
NOSIP nitric oxide synthase interacting protein 2.64061
LPAR2 lysophosphatidic acid receptor 2 2.63469
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.43347
CBR3 carbonyl reductase 3 2.35188
CHN1 chimerin 1 2.26051
BAX BCL2-associated X protein 2.11989
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.01059

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -5.14947
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.97798
ZNF586 zinc finger protein 586 -4.93019
CD320 CD320 molecule -4.57716
SLC35F2 solute carrier family 35, member F2 -4.30423
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.28849
FAIM Fas apoptotic inhibitory molecule -3.36506
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.18557
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.16478
MRPS2 mitochondrial ribosomal protein S2 -2.61981
EIF5 eukaryotic translation initiation factor 5 -2.56716
MAPK13 mitogen-activated protein kinase 13 -2.56087
SNX11 sorting nexin 11 -2.39399
ARID5B AT rich interactive domain 5B (MRF1-like) -2.35029
TLCD3A TLC domain containing 3A -2.33972
HLA-DMA major histocompatibility complex, class II, DM alpha -2.19429
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.10437