CRCGN014_HEPG2_24H:L09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description a-1,2,3,4,5,6-hexachlorocyclohexane 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN014_HEPG2_24H:L09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 5.60253
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.78878
EPHB2 EPH receptor B2 4.22097
CHN1 chimerin 1 3.27316
GSTZ1 glutathione S-transferase zeta 1 2.96571
STK10 serine/threonine kinase 10 2.89209
GPATCH8 G patch domain containing 8 2.68311
MOK MOK protein kinase 2.58594
SOCS2 suppressor of cytokine signaling 2 2.52472
CHEK2 checkpoint kinase 2 2.36415
PPARG peroxisome proliferator-activated receptor gamma 2.34612
DIPK1A divergent protein kinase domain 1A 2.26498
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.26423

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.30684
ADI1 acireductone dioxygenase 1 -5.09941
LDHD lactate dehydrogenase D -4.69324
MAPK13 mitogen-activated protein kinase 13 -3.38217
VDAC1 voltage-dependent anion channel 1 -3.17158
CCDC86 coiled-coil domain containing 86 -2.68998
ZNF586 zinc finger protein 586 -2.40115
LOC124907782 dual specificity protein phosphatase 22 -2.38567
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.38236
TEX10 testis expressed 10 -2.36168
PLK1 polo-like kinase 1 -2.32001
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.25772
SPAG4 sperm associated antigen 4 -2.25198
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.1201
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.03352
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.0101