CRCGN014_HEPG2_24H:L10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMBA 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

230 genes differentially expressed following the CRCGN014_HEPG2_24H:L10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP1 inositol polyphosphate-1-phosphatase 6.25272
CDPF1 cysteine-rich, DPF motif domain containing 1 6.1877
ABHD4 abhydrolase domain containing 4 5.66571
BLCAP bladder cancer associated protein 5.6639
GPC1 glypican 1 5.40796
TUBB6 tubulin, beta 6 class V 5.11085
MICALL1 MICAL-like 1 5.09531
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.95984
LSR lipolysis stimulated lipoprotein receptor 4.90104
DUSP14 dual specificity phosphatase 14 4.75746
DDB2 damage-specific DNA binding protein 2, 48kDa 4.42369
CNPY3 canopy FGF signaling regulator 3 4.26674
TXNRD1 thioredoxin reductase 1 4.20845
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.02919
CCP110 centriolar coiled coil protein 110kDa 3.89896
KEAP1 kelch-like ECH-associated protein 1 3.8467
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.68524
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 3.65191
VAT1 vesicle amine transport 1 3.63993
UBQLN2 ubiquilin 2 3.51056
FOSL1 FOS-like antigen 1 3.48243
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.47825
SQSTM1 sequestosome 1 3.44909
SKIC2 SKI2 subunit of superkiller complex 3.34385
LCN2 lipocalin 2 3.33092
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.32035
ANO1 anoctamin 1, calcium activated chloride channel 3.223
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.16249
CIAO3 cytosolic iron-sulfur assembly component 3 3.16191
KLHL21 kelch-like family member 21 3.14951
SQOR sulfide quinone oxidoreductase 3.12252
ZFP36 ZFP36 ring finger protein 3.10025
CCDC92 coiled-coil domain containing 92 3.09451
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.0745
LYN LYN proto-oncogene, Src family tyrosine kinase 3.0737
AMDHD2 amidohydrolase domain containing 2 3.02726
TOMM34 translocase of outer mitochondrial membrane 34 2.98814
CCNA1 cyclin A1 2.92302
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.89399
DDIT4 DNA-damage-inducible transcript 4 2.88348
TIMP2 TIMP metallopeptidase inhibitor 2 2.87753
CBR3 carbonyl reductase 3 2.8739
IL4R interleukin 4 receptor 2.84244
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.78878
NPDC1 neural proliferation, differentiation and control, 1 2.74474
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.73098
OSGIN1 oxidative stress induced growth inhibitor 1 2.68826
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.64278
STX1A syntaxin 1A (brain) 2.63799
IER3 immediate early response 3 2.6119
CYCS cytochrome c, somatic 2.61139
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.52556
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.52512
PNKP polynucleotide kinase 3'-phosphatase 2.52221
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.50577
ATG2A autophagy related 2A 2.49356
SPATA20 spermatogenesis associated 20 2.47331
KIFBP kinesin family binding protein 2.45975
MAST2 microtubule associated serine/threonine kinase 2 2.45747
CCDC86 coiled-coil domain containing 86 2.44565
DYNLT3 dynein, light chain, Tctex-type 3 2.44492
MAP7 microtubule-associated protein 7 2.44219
TIGAR TP53 induced glycolysis regulatory phosphatase 2.43366
ZNF646 zinc finger protein 646 2.43317
NANOS3 nanos homolog 3 (Drosophila) 2.43255
HAND2 heart and neural crest derivatives expressed 2 2.42081
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.40032
STIMATE STIM activating enhancer 2.37529
RTL10 retrotransposon Gag like 10 2.36641
TRIM62 tripartite motif containing 62 2.35453
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.3426
TARS1 threonyl-tRNA synthetase 1 2.34134
CASC3 cancer susceptibility candidate 3 2.33827
RALB v-ral simian leukemia viral oncogene homolog B 2.33759
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.31535
LOC128125814 uncharacterized LOC128125814 2.29822
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.29269
TERF2IP telomeric repeat binding factor 2, interacting protein 2.28385
DRD4 dopamine receptor D4 2.28054
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.27795
OGDHL oxoglutarate dehydrogenase-like 2.27729
ATF3 activating transcription factor 3 2.24974
CYTH2 cytohesin 2 2.23561
NT5C 5', 3'-nucleotidase, cytosolic 2.23373
MAPK12 mitogen-activated protein kinase 12 2.22762
MCOLN1 mucolipin 1 2.2166
DUSP6 dual specificity phosphatase 6 2.19864
RIN1 Ras and Rab interactor 1 2.19573
MAP7D1 MAP7 domain containing 1 2.19082
TP53I3 tumor protein p53 inducible protein 3 2.18849
UNC13D unc-13 homolog D (C. elegans) 2.18171
ASB8 ankyrin repeat and SOCS box containing 8 2.17977
MAPK13 mitogen-activated protein kinase 13 2.17182
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.16729
AMPD2 adenosine monophosphate deaminase 2 2.15856
GADD45A growth arrest and DNA-damage-inducible, alpha 2.15115
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.14149
AEN apoptosis enhancing nuclease 2.1379
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.13776
PRKCQ protein kinase C, theta 2.13655
YARS1 tyrosyl-tRNA synthetase 1 2.1365
MOK MOK protein kinase 2.13083
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.11958
GIPC1 GIPC PDZ domain containing family, member 1 2.11589
UIMC1 ubiquitin interaction motif containing 1 2.10484
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.10074
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.09784
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2.08277
FBXO2 F-box protein 2 2.07727
CALCOCO2 calcium binding and coiled-coil domain 2 2.06491
ZNF195 zinc finger protein 195 2.05261
PLCH2 phospholipase C, eta 2 2.05078
DSG2 desmoglein 2 2.04422
RNASE12 ribonuclease, RNase A family, 12 (non-active) 2.02963
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.02722
TCF15 transcription factor 15 (basic helix-loop-helix) 2.02201
XPC xeroderma pigmentosum, complementation group C 2.01148
IGFALS insulin-like growth factor binding protein, acid labile subunit 2.00779
RRAGC Ras-related GTP binding C 2.00397
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.00145
TREM2 triggering receptor expressed on myeloid cells 2 2.0002

decreased expression

Symbol Name Standardized Value
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -6.30699
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.11823
ISOC1 isochorismatase domain containing 1 -5.76135
CDC20 cell division cycle 20 -5.05816
PSRC1 proline/serine-rich coiled-coil 1 -4.82223
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.80246
DERA deoxyribose-phosphate aldolase (putative) -4.75662
PCNA proliferating cell nuclear antigen -4.62449
PECR peroxisomal trans-2-enoyl-CoA reductase -4.56901
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.39093
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.38392
TLR4 toll-like receptor 4 -4.33966
TCTN1 tectonic family member 1 -4.17257
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.94078
ADI1 acireductone dioxygenase 1 -3.93674
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.89008
PLS1 plastin 1 -3.88338
ZMIZ1 zinc finger, MIZ-type containing 1 -3.83974
MSRA methionine sulfoxide reductase A -3.77783
MNAT1 MNAT CDK-activating kinase assembly factor 1 -3.72357
C2CD5 C2 calcium-dependent domain containing 5 -3.61037
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.6064
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.55793
AURKB aurora kinase B -3.53496
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.48531
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.45433
KLHDC2 kelch domain containing 2 -3.40373
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.37198
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -3.33491
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.32513
PEG10 paternally expressed 10 -3.21896
GTPBP8 GTP-binding protein 8 (putative) -3.18674
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.17352
ZDHHC6 zinc finger, DHHC-type containing 6 -3.15923
PGM1 phosphoglucomutase 1 -3.11996
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -3.02308
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.00253
PLK1 polo-like kinase 1 -2.98969
HMGA2 high mobility group AT-hook 2 -2.97215
MYLK myosin light chain kinase -2.92227
RSU1 Ras suppressor protein 1 -2.90675
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.89539
SOAT2 sterol O-acyltransferase 2 -2.85974
ACAA1 acetyl-CoA acyltransferase 1 -2.83455
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.79068
STX8 syntaxin 8 -2.74153
TMEM109 transmembrane protein 109 -2.69471
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.68344
CCNA2 cyclin A2 -2.67272
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.66388
ICAM3 intercellular adhesion molecule 3 -2.62594
CCNB2 cyclin B2 -2.62285
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.58494
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.57472
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.51667
MELK maternal embryonic leucine zipper kinase -2.50818
BABAM1 BRISC and BRCA1 A complex member 1 -2.49285
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.44141
BLMH bleomycin hydrolase -2.42919
ATF6 activating transcription factor 6 -2.42804
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.41573
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.38544
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.35372
RNASE4 ribonuclease, RNase A family, 4 -2.3523
RFC2 replication factor C (activator 1) 2, 40kDa -2.34086
LBR lamin B receptor -2.32302
PDZD2 PDZ domain containing 2 -2.3045
RGS18 regulator of G-protein signaling 18 -2.29237
PXMP2 peroxisomal membrane protein 2, 22kDa -2.29026
NT5DC2 5'-nucleotidase domain containing 2 -2.27832
IL33 interleukin 33 -2.27236
ADTRP androgen-dependent TFPI-regulating protein -2.25817
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.25381
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.25093
TP53BP2 tumor protein p53 binding protein 2 -2.24306
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.22361
NLGN4Y neuroligin 4, Y-linked -2.20627
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.20412
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa -2.19393
KIF15 kinesin family member 15 -2.18784
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.18709
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -2.18019
SRI sorcin -2.16883
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -2.1628
ADAMDEC1 ADAM-like, decysin 1 -2.14176
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.13854
FBXO5 F-box protein 5 -2.11743
GNAS GNAS complex locus -2.11539
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.10589
EDN1 endothelin 1 -2.08775
RHOBTB1 Rho-related BTB domain containing 1 -2.08773
DUT deoxyuridine triphosphatase -2.08222
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.07793
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.07773
DENND2D DENN/MADD domain containing 2D -2.07687
TMEM254 transmembrane protein 254 -2.07292
NHLRC2 NHL repeat containing 2 -2.07025
MSH6 mutS homolog 6 -2.06243
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -2.05671
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.05435
ADAMTSL3 ADAMTS-like 3 -2.05415
ZNF623 zinc finger protein 623 -2.04579
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.04039
MYLK3 myosin light chain kinase 3 -2.03367
PARM1 prostate androgen-regulated mucin-like protein 1 -2.01051
SUSD5 sushi domain containing 5 -2.00476
CD36 CD36 molecule (thrombospondin receptor) -2.00389
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -2.00346
HADH hydroxyacyl-CoA dehydrogenase -2.00009