CRCGN014_HEPG2_24H:L11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description safrole 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN014_HEPG2_24H:L11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 5.204
MOK MOK protein kinase 4.60454
CBR3 carbonyl reductase 3 4.46796
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.35914
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.35886
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.25005
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.05185
BAD BCL2-associated agonist of cell death 3.73914
TBPL1 TBP-like 1 3.4542
SQOR sulfide quinone oxidoreductase 3.42846
ABHD6 abhydrolase domain containing 6 3.22639
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.99251
CDPF1 cysteine-rich, DPF motif domain containing 1 2.97689
LOC122526780 uncharacterized LOC122526780 2.95396
PRR15L proline rich 15-like 2.21772
CCNF cyclin F 2.184
STIMATE STIM activating enhancer 2.04348

decreased expression

Symbol Name Standardized Value
FGFR4 fibroblast growth factor receptor 4 -6.61738
LDHD lactate dehydrogenase D -5.287
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.69211
CHMP4B charged multivesicular body protein 4B -4.37489
FAIM Fas apoptotic inhibitory molecule -4.21998
CCNB2 cyclin B2 -3.7421
DERA deoxyribose-phosphate aldolase (putative) -3.60871
RNF167 ring finger protein 167 -3.17145
TLR4 toll-like receptor 4 -2.78336
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.68899
GNAS GNAS complex locus -2.2312