CRCGN014_HEPG2_24H:L12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description emodin 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

93 genes differentially expressed following the CRCGN014_HEPG2_24H:L12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 6.41899
LCN2 lipocalin 2 6.11931
TXNRD1 thioredoxin reductase 1 5.85181
CBR1 carbonyl reductase 1 5.56383
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 5.06574
GSTZ1 glutathione S-transferase zeta 1 4.95352
CYCS cytochrome c, somatic 4.62358
MAP7 microtubule-associated protein 7 4.38654
MAMLD1 mastermind-like domain containing 1 4.11043
HMOX1 heme oxygenase 1 4.08073
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.70147
ABHD4 abhydrolase domain containing 4 3.61033
CIAO3 cytosolic iron-sulfur assembly component 3 3.59612
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.50003
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.37638
GAA glucosidase, alpha; acid 3.34534
LSR lipolysis stimulated lipoprotein receptor 3.33317
HLA-DRA major histocompatibility complex, class II, DR alpha 3.29789
CHMP6 charged multivesicular body protein 6 3.04563
PPARG peroxisome proliferator-activated receptor gamma 2.94624
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.80322
CCP110 centriolar coiled coil protein 110kDa 2.73461
E2F2 E2F transcription factor 2 2.69955
KIFBP kinesin family binding protein 2.64486
TIMP2 TIMP metallopeptidase inhibitor 2 2.59754
CCDC92 coiled-coil domain containing 92 2.5967
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.56978
ANKRD10 ankyrin repeat domain 10 2.56439
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.45332
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 2.45077
SLC25A46 solute carrier family 25, member 46 2.35004
KEAP1 kelch-like ECH-associated protein 1 2.34482
BLMH bleomycin hydrolase 2.32508
BACE2 beta-site APP-cleaving enzyme 2 2.27865
SQSTM1 sequestosome 1 2.27658
EPHB2 EPH receptor B2 2.25568
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.18016
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.16715
MVP major vault protein 2.15219
RPS5 ribosomal protein S5 2.15166
STXBP2 syntaxin binding protein 2 2.13089
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.11597
TRIM16 tripartite motif containing 16 2.11571
JADE2 jade family PHD finger 2 2.1157
CDPF1 cysteine-rich, DPF motif domain containing 1 2.10858
VAT1 vesicle amine transport 1 2.07254
JMJD1C jumonji domain containing 1C 2.07112
KLK11 kallikrein-related peptidase 11 2.0651
TARS1 threonyl-tRNA synthetase 1 2.05793
CASC3 cancer susceptibility candidate 3 2.04989
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.02277
SLC67A1 solute carrier family 67 member 1 2.01347
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.00758

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.12188
DNM1L dynamin 1-like -6.42991
PCNA proliferating cell nuclear antigen -4.39694
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.1658
ISOC1 isochorismatase domain containing 1 -4.05377
LAP3 leucine aminopeptidase 3 -3.99859
GNAS GNAS complex locus -3.78026
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.20768
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.16738
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.1668
CCDC86 coiled-coil domain containing 86 -3.15123
TLCD3A TLC domain containing 3A -3.07111
ELAC2 elaC ribonuclease Z 2 -3.02311
OXA1L oxidase (cytochrome c) assembly 1-like -2.92176
PCCB propionyl CoA carboxylase, beta polypeptide -2.84742
NRIP1 nuclear receptor interacting protein 1 -2.77498
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.7691
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.76719
FGFR4 fibroblast growth factor receptor 4 -2.71363
MRPS2 mitochondrial ribosomal protein S2 -2.66466
PPOX protoporphyrinogen oxidase -2.65282
TOMM34 translocase of outer mitochondrial membrane 34 -2.59771
ZMIZ1 zinc finger, MIZ-type containing 1 -2.58719
NGRN neugrin, neurite outgrowth associated -2.47172
MYL9 myosin, light chain 9, regulatory -2.38799
EGF epidermal growth factor -2.37349
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.36942
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.34159
CROT carnitine O-octanoyltransferase -2.32366
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.28765
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.20373
RYR3 ryanodine receptor 3 -2.18849
SOAT2 sterol O-acyltransferase 2 -2.17704
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.17426
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.1705
ZDHHC6 zinc finger, DHHC-type containing 6 -2.14944
SLC35F2 solute carrier family 35, member F2 -2.06041
SLITRK3 SLIT and NTRK-like family, member 3 -2.04645
CDKN2A cyclin-dependent kinase inhibitor 2A -2.04467
PCDH17 protocadherin 17 -2.02033